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Published in: Cancer Chemotherapy and Pharmacology 2/2020

01-08-2020 | Glioblastoma | Review Article

Advances in histone deacetylase inhibitors in targeting glioblastoma stem cells

Authors: R. Gajendra Reddy, Unis Ahmad Bhat, Sumana Chakravarty, Arvind Kumar

Published in: Cancer Chemotherapy and Pharmacology | Issue 2/2020

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Abstract

Glioblastoma multiforme (GBM) is a lethal grade IV glioma (WHO classification) and widely prevalent primary brain tumor in adults. GBM tumors harbor cellular heterogeneity with the presence of a small subpopulation of tumor cells, described as GBM cancer stem cells (CSCs) that pose resistance to standard anticancer regimens and eventually mediate aggressive relapse or intractable progressive GBM. Existing conventional anticancer therapies for GBM do not target GBM stem cells and are mostly palliative; therefore, exploration of new strategies to target stem cells of GBM has to be prioritized for the development of effective GBM therapy. Recent developments in the understanding of GBM pathophysiology demonstrated dysregulation of epigenetic mechanisms along with the genetic changes in GBM CSCs. Altered expression/activity of key epigenetic regulators, especially histone deacetylases (HDACs) in GBM stem cells has been associated with poor prognosis; inhibiting the activity of HDACs using histone deacetylase inhibitors (HDACi) has been promising as mono-therapeutic in targeting GBM and in sensitizing GBM stem cells to an existing anticancer regimen. Here, we review the development of pan/selective HDACi as potential anticancer agents in targeting the stem cells of glioblastoma as a mono or combination therapy.
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Metadata
Title
Advances in histone deacetylase inhibitors in targeting glioblastoma stem cells
Authors
R. Gajendra Reddy
Unis Ahmad Bhat
Sumana Chakravarty
Arvind Kumar
Publication date
01-08-2020
Publisher
Springer Berlin Heidelberg
Published in
Cancer Chemotherapy and Pharmacology / Issue 2/2020
Print ISSN: 0344-5704
Electronic ISSN: 1432-0843
DOI
https://doi.org/10.1007/s00280-020-04109-w

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