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Cancer Chemotherapy and Pharmacology

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01-07-2019 | Ovarian Cancer | Original Article

Platinum-free interval affects efficacy of following treatment for platinum-refractory or -resistant ovarian cancer

Authors: Mayumi Kobayashi-Kato, Mayu Yunokawa, Seiko Bun, Naoyuki Miyasaka, Tomoyasu Kato, Kenji Tamura

Published in: Cancer Chemotherapy and Pharmacology | Issue 1/2019

Abstract

Background/objective

Platinum-refractory or -resistant ovarian cancer (PRROC) is associated with poor prognosis and low response to further chemotherapy. We investigated predictors of effectiveness of following treatments for PRROC.

Patients and methods

We included 380 patients diagnosed with stage I–IV ovarian, fallopian tube, or primary peritoneal cancer, who were treated at the National Cancer Center Hospital in Japan from January 2007 to December 2014 and recurred after initial treatment, who had a platinum-refractory or -resistant relapses and received chemotherapy, in this single-center, retrospective study. We investigated factors related to response to following treatment, and to progression-free survival (PFS).

Results

Among 183 patients (48%) who suffered recurrences, 62 (34%) developed PRROC after chemotherapy. In multivariate analysis, platinum-free interval (PFI) < 3 months was independently associated with progressive disease (odds ratio [OR] 6.043, 95% confidence interval [CI] 1.485–24.595, P = 0.012). Median PFS was 139 days (95% CI 19.4–258) among patients with PFI > 3 months, but was 57 days (95% CI 34.7–79.2) among those with PFI < 3 months. In multivariate analysis, two factors, performance status (PS) 1–2 (HR 1.915, 95% CI 1.074–3.415, P = 0.028) and PFI < 3 months (HR 1.943, 95% CI 1.109–3.403, P = 0.02), were independently associated with worse PFS.

Conclusions

PS 1–2 and PFI < 3 months were significant predictors of poor response to following treatment for PRROC. Risks and benefits of treatment should be frankly discussed with patients who have these characteristics.

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Title: Platinum-free interval affects efficacy of following treatment for platinum-refractory or -resistant ovarian cancer
Authors: Mayumi Kobayashi-Kato
Mayu Yunokawa
Seiko Bun
Naoyuki Miyasaka
Tomoyasu Kato
Kenji Tamura
Publication date: 01-07-2019
Publisher: Springer Berlin Heidelberg
Keywords: Ovarian Cancer
Ovarian Cancer
Bevacizumab
Cytostatic Therapy
Peritoneal Cancer
Peritoneal Carcinomatosis
Published in: Cancer Chemotherapy and Pharmacology / Issue 1/2019
Print ISSN: 0344-5704
Electronic ISSN: 1432-0843
DOI: https://doi.org/10.1007/s00280-019-03834-1

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