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01-04-2015 | Original Article

Cisplatin in combination with metronomic vinorelbine as front-line treatment in advanced non-small cell lung cancer: a multicenter phase II study of the Hellenic Oncology Research Group (HORG)

Authors: P. Katsaounis, A. Kotsakis, S. Agelaki, E. Kontopodis, A. Agelidou, N. Kentepozidis, L. Vamvakas, A. Christopoulou, N. Karachaliou, D. Hatzidaki, V. Georgoulias

Published in: Cancer Chemotherapy and Pharmacology | Issue 4/2015

Abstract

Purpose

To evaluate the safety and efficacy of metronomic vinorelbine in combination with cisplatin as first-line treatment in patients with advanced non-small cell lung cancer (NSCLC).

Patients and methods

A total of 41 patients with inoperable stage IIIb or stage IV NSCLC (14 with adenocarcinomas, 19 with squamous cell carcinoma and eight with other types), PS = 0–2, were treated with cisplatin (80 mg/m²) in combination with oral metronomic vinorelbine (60 mg total dose, every other day) in cycles of 21 days.

Results

A total of 35 patients who received at least one cycle of chemotherapy were evaluable for toxicity and response. Partial response was achieved in 13 patients (ORR 37.1 %; CI 21.1–53.1 %) and stable disease in 10 (28.6 %). After a median follow-up period of 26.2 months (range 0.5–33.4 months), the median progression-free survival was 4.2 months and the median overall survival 12.0 months. The 1-year survival rate was 52.6 %. Myelosuppression was the main adverse event with grade 3 and 4 neutropenia occurring in five (14.3 %) and six (17.1 %) patients, respectively. Three of these patients presented with febrile neutropenia and there was one death due to sepsis. Non-hematologic toxicities were mild.

Conclusion

Cisplatin in combination with metronomic vinorelbine is an active, although myelotoxic, therapeutic option in the first-line setting for the treatment of patients with locally advanced and metastatic non-small cell lung cancer, which merits further evaluation in randomized trials.

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Title: Cisplatin in combination with metronomic vinorelbine as front-line treatment in advanced non-small cell lung cancer: a multicenter phase II study of the Hellenic Oncology Research Group (HORG)
Authors: P. Katsaounis
A. Kotsakis
S. Agelaki
E. Kontopodis
A. Agelidou
N. Kentepozidis
L. Vamvakas
A. Christopoulou
N. Karachaliou
D. Hatzidaki
V. Georgoulias
Publication date: 01-04-2015
Publisher: Springer Berlin Heidelberg
Published in: Cancer Chemotherapy and Pharmacology / Issue 4/2015
Print ISSN: 0344-5704
Electronic ISSN: 1432-0843
DOI: https://doi.org/10.1007/s00280-015-2707-x

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