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Cancer Chemotherapy and Pharmacology
Published in: Cancer Chemotherapy and Pharmacology 6/2009

01-11-2009 | Original Article

Outcome of upfront combination chemotherapy followed by chemoradiation for locally advanced pancreatic adenocarcinoma

Authors: Michele Reni, S. Cereda, G. Balzano, P. Passoni, A. Rognone, A. Zerbi, R. Nicoletti, E. Mazza, P. G. Arcidiacono, V. Di Carlo, E. Villa

Published in: Cancer Chemotherapy and Pharmacology | Issue 6/2009

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Abstract

Purpose

The role and timing of chemotherapy and radiation for treating stage III pancreatic adenocarcinoma remains controversial.

Methods

Treatment-naive patients with stage III non-resectable pancreatic adenocarcinoma were treated with PEFG/PEXG (cisplatin, epirubicin, 5-fluorouracil (F)/capecitabine (X), gemcitabine) or PDXG (docetaxel substituting epirubicin) regimen for 6 months followed by radiotherapy (50–60 Gy) with concurrent F or X or G.

Results

Ninety-one patients were registered between April 1997 and December 2007. Forty-three patients (47%) had a partial remission and 38 (42%) had a stable disease. Thirteen patients (14%) were radically resected yielding one pathologic complete remission. Median survival (OS) was 16.2 months. Median progression-free survival was 9.9 months. Pattern of failure consisted of isolated local failure (N = 26, 35%); both local and systemic failure (N = 14, 19%); isolated systemic failure (N = 35, 47%).

Conclusion

Combination chemotherapy with four-drug regimens followed by chemoradiation was a feasible strategy showing relevant results in stage III pancreatic adenocarcinoma.
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Metadata
Title
Outcome of upfront combination chemotherapy followed by chemoradiation for locally advanced pancreatic adenocarcinoma
Authors
Michele Reni
S. Cereda
G. Balzano
P. Passoni
A. Rognone
A. Zerbi
R. Nicoletti
E. Mazza
P. G. Arcidiacono
V. Di Carlo
E. Villa
Publication date
01-11-2009
Publisher
Springer-Verlag
Published in
Cancer Chemotherapy and Pharmacology / Issue 6/2009
Print ISSN: 0344-5704
Electronic ISSN: 1432-0843
DOI
https://doi.org/10.1007/s00280-009-0995-8

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