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01-11-2013 | Original Article

Children and adolescents with follicular lymphoma have an excellent prognosis with either limited chemotherapy or with a “watch and wait” strategy after complete resection

Authors: Andishe Attarbaschi, Auke Beishuizen, Georg Mann, Angelo Rosolen, Tetsuya Mori, Anne Uyttebroeck, Felix Niggli, Monika Csoka, Zdenka Krenova, Karin Mellgren, Edita Kabickova, Alan KS Chiang, Alfred Reiter, Denise Williams, Birgit Burkhardt, on behalf of the European Intergroup for Childhood Non-Hodgkin Lymphoma (EICNHL) and the international Berlin-Frankfurt-Münster (i-BFM) Study Group

Published in: Annals of Hematology | Issue 11/2013

Abstract

Data on clinical features and outcome in pediatric follicular lymphoma (pFL) are scarce. The aim of this retrospective study including 13 EICNHL and/or i-BFM study group members was to assess clinical characteristics and course in a series of 63 pFL patients. pFL was found to be associated with male gender (3:1), older age (72 % ≥10 years old), low serum LDH levels (<500 U/l in 75 %), grade 3 histology (in 88 %), and limited disease (87 % stage I/II disease), mostly involving the peripheral lymph nodes. Forty-four out of sixty-three patients received any polychemotherapy and 1/63 rituximab only, while 17/63 underwent a “watch and wait” strategy. Of 36 stage I patients, 30 had complete resections. Only one patient relapsed; 2-year event-free survival and overall survival were 94 ± 5 and 100 %, respectively, after a median follow-up of 2.2 years. Conclusively, treatment outcome in pFL seems to be excellent with risk-adapted chemotherapy or after complete resection and an observational strategy only.

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Title: Children and adolescents with follicular lymphoma have an excellent prognosis with either limited chemotherapy or with a “watch and wait” strategy after complete resection
Authors: Andishe Attarbaschi
Auke Beishuizen
Georg Mann
Angelo Rosolen
Tetsuya Mori
Anne Uyttebroeck
Felix Niggli
Monika Csoka
Zdenka Krenova
Karin Mellgren
Edita Kabickova
Alan KS Chiang
Alfred Reiter
Denise Williams
Birgit Burkhardt
on behalf of the European Intergroup for Childhood Non-Hodgkin Lymphoma (EICNHL) and the international Berlin-Frankfurt-Münster (i-BFM) Study Group
Publication date: 01-11-2013
Publisher: Springer Berlin Heidelberg
Published in: Annals of Hematology / Issue 11/2013
Print ISSN: 0939-5555
Electronic ISSN: 1432-0584
DOI: https://doi.org/10.1007/s00277-013-1785-2

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