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Surgical and Radiologic Anatomy
Published in: Surgical and Radiologic Anatomy 1/2014

01-01-2014 | Original Article

Evaluation of corpus callosum morphometry in patients with mesial temporal lobe epilepsy with hippocampal sclerosis

Authors: A. Firat, A. B. Tascioglu, M. D. Demiryurek, S. Saygi, K. Karli Oguz, F. I. Tezer, M. Hayran

Published in: Surgical and Radiologic Anatomy | Issue 1/2014

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Abstract

Purpose

The purpose of the study was to evaluate the effects of mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) on corpus callosum (CC) morphometry in large and pathologically proven MTLE-HS patients.

Methods

We measured certain CC dimensions in 103 patients and 33 healthy controls using in vivo magnetic resonance imaging. In particular, we compared the two groups in relation to the clinical (localization of the HS, duration of epilepsy, frequency of seizures and length of seizures) and demographical (age, gender, handedness) features. Students’ t test, two-way ANOVA and Spearman test were used for statistical analysis.

Results

There was no significant difference between CC morphometry with respect to age and handedness among patients. The differences between the genders, however, were significant favouring longer diameters in males. We found significant decrease in the dimensions of the genu, body, isthmus and splenium of the CC in the MTLE-HS group, but there was no reduction in the size of the rostrum.

Conclusions

This general reduction in the size of the CC except for the rostrum was thought to be the result of cortical atrophy secondary to the disease. Concerning the preserved rostral part of the CC, it was thought that the fibers of the frontal lobe pass through different pathways than the tracts in the rostrum.
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Metadata
Title
Evaluation of corpus callosum morphometry in patients with mesial temporal lobe epilepsy with hippocampal sclerosis
Authors
A. Firat
A. B. Tascioglu
M. D. Demiryurek
S. Saygi
K. Karli Oguz
F. I. Tezer
M. Hayran
Publication date
01-01-2014
Publisher
Springer Paris
Published in
Surgical and Radiologic Anatomy / Issue 1/2014
Print ISSN: 0930-1038
Electronic ISSN: 1279-8517
DOI
https://doi.org/10.1007/s00276-013-1144-y

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