Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Surgical and Radiologic Anatomy
Published in: Surgical and Radiologic Anatomy 10/2012

01-12-2012 | Original Article

Age-related volumetric changes in pancreas: a stereological study on computed tomography

Authors: Veli Caglar, Ahmet Songur, Murat Yagmurca, Murat Acar, Muhsin Toktas, Yucel Gonul

Published in: Surgical and Radiologic Anatomy | Issue 10/2012

Login to get access

Abstract

Purpose

(1) To explore age-related changes in the volume of the pancreas on computed tomography (CT) images calculated by the method of Cavalieri. (2) To investigate the relationship between these changes and body mass index (BMI), gender, abdominal diameter, abdominal skinfold thickness.

Methods

We retrospectively reviewed abdominal CT examinations of 272 adults between the ages of 20–88 years. There were seven groups of patients, with 40 patients (only ninth decade has 32 patients) for each decade.

Results

Pancreatic volume (PV) was found to be 63.68 ± 15.08 cm3 in females, 71.75 ± 15.99 cm3 in males (mean value of both groups, 67.71 ± 16.03 cm3). Maximum value of PV was found in the fourth decade in females, males and also for mean of both groups (73.50, 84.21 and 78.85 cm3, respectively). PV remained constant until ~60 years of age. Thereafter, it gradually decreased in both genders. There was a negative correlation between PV and age (p < 0.001, r: −0.473). We found positive correlation between PV and BMI, sagittal abdominal diameter (SAD), transverse abdominal diameter (TAD), anterior subcutaneous adipose tissue thicknesses (ASAT), posterior subcutaneous adipose tissue thicknesses (PSAT), bilateral subcutaneous adipose tissue thicknesses (BSAT).

Conclusions

Quantitative data may allow clinicians to better estimate age-related PV changes and help them in decision making.
Literature
1.
Canan S, Şahin B, Odacı E, Ünal B, Aslan H, Bilgiç S, Kaplan S (2002) Toplam hacim, hacim yoğunluğu ve hacim oranlarının hesaplanmasında kullanılan bir stereolojik yöntem: cavalieri prensibi. Türkiye Klinikleri Tıp Bilimleri 22(1):7–14
2.
Chiarelli F, Verrotti A, Altobelli E, Blasetti A, Morgese G (1995) Size of the pancreas in type 1 diabetic children and adolescents. Diabet Care 18:1505–1506
3.
D’Anunzio G, Chiara A, Lorini R (1996) Pancreatic gland size reduction and exocrine impairment in type 1 diabetic children. Diabet Care 19:777–778
4.
De La Grandmaison GL, Clariand I, Durigon M (2001) Organ weigh in 684 adult autopsies: new tables for a Caucasoid population. Forensic Sci Int 119:149–154PubMedCrossRef
5.
Geraghty EM, Boone JM, Mcgahan JP, Jain K (2004) Normal organ volume assessment from abdominal CT. Abdom Imaging 29:482–490PubMedCrossRef
6.
Goda K, Sasaki E, Nagata K, Fukai M, Ohsawa N, Hahafusa T (2001) Pancreatic volume in type 1 and type 2 diabetes mellitus. Acta Diabetol 38:145–149PubMedCrossRef
7.
Goh S, Price RI, Song S, Davis S, Singer KP (2000) Magnetic resonance-based vertebral morphometry of the thoracic spine: age, gender and level-specific influences. Clin Biomech 15(6):417–425CrossRef
8.
Heuck A, Maubach PA, Reiser M, Feuerbach S, Allgayer B, Lukas P, Kahn T (1987) Age-related morphology of the normal pancreas on computed tomography. Gastrointest Radiol 12:18–22PubMedCrossRef
9.
Kanaya AM, Lindquist K, Harrıs TB, Launer L, Rosano C, Satterfield S, Yaffe K (2009) Total and regional adiposity and cognitive change in older adults. Arch Neurol 66(3):329–335PubMedCrossRef
10.
Kloppel G, Lohr M, Habıch K, Oberholzer M, Heıtz PU (1985) Islet pathology and pathogenesis of type 1 and type 2 diabetes mellitus revisited. Surv Synth Path Res 4:110–125
11.
Kvist H, Chowdhury B, Grangard U, Tylen U, Sjostrom L (1988) Total and visceral adipose-tissue volumes derived from measurements with computed tomography in adult men and women: predictive equations. Am J Clin Nutr 48:1351–1361PubMed
12.
Lang T, Augat P, Majumdar S, Ouyang X, Genant HK (1998) Noninvasive assessment of bone density and structure using computed tomography and magnetic resonance. Bone 22(5):149–153CrossRef
13.
Lean MEJ, Han TS, Morrison C (1995) Waist circumference as a measure for indicating need for weight management. BMJ 311:158–161PubMedCrossRef
14.
Lohr M, Kloppel G (1987) Residual insulin positivity and pancreatic atrophy in relation to duration of chronic type 1 (insulin dependent) diabetes mellitus and microangiopathy. Diabetologia 30:757–762PubMedCrossRef
15.
Mortelé KJ, Rocha TC, Streeter JL, Taylor AJ (2006) Multimodality imaging of pancreatic and biliary congenital anomalies. Radio Graph 26:715–731
16.
Mouton PR (2011) Unbiased stereology: a concise guide. The Johns Hopkins University Press, Baltimore, pp 26–32
17.
Odaci E, Bahadir A, Yildirim Ş, Şahin B, Canan S, Baş O, Bilgiç S, Kaplan S (2005) Cavalieri metodu kullanılarak bilgisayarlı tomografi ve manyetik rezonans görüntüleri üzerinden hacim hesaplanması ve klinik kullanımı. Türkiye Klinikleri J Med Sci 25:421–428
18.
Ogiu N, Nakamura Y, Ijiri I, Hiraiwa K, Ogiu T (1997) A statistical analysis of the internal organ weights of normal Japanese people. Health Phys 72:368–383PubMedCrossRef
19.
20.
Pouliot MC, Despres JP, Lemieux S, Moorjani S, Bouchard C, Tremblay A, Nadeau A, Lupien PJ (1994) Waist circumference and abdominal sagittal diameter: best simple anthropometric indexes of abdominal visceral adipose tissue accumulation and related cardiovascular risk in men and women. Am J Cardiol 73:460–468PubMedCrossRef
21.
Riserus U, Arnlov J, Brismar K, Zethelius B, Berglund L, Vessby B (2004) Sagittal abdominal diameter is a strong anthropometric marker of insulin resistance and hyperproinsulinemia in obese men. Diabet Care 27:2041–2046CrossRef
22.
Roberts N, Puddephat MJ, McNulty V (2000) The benefit of stereology for quantitative radiology. Br J Radiol 73:679–697PubMed
23.
Saisho Y, Butler AE, Meier JJ, Monchamp T, Allen-Auerbach M, Rizza RA, Butler PC (2007) Pancreas volumes in humans from birth to age one hundred taking ınto account sex, obesity, and presence of type-2 diabetes. Clin Anat 20:933–942PubMedCrossRef
24.
Schinina V, Rizzi EB, Rovighi L, Carli G, David V, Bibbolino C (2001) Infectious spondylodiscitis: magnetic resonance imaging in HIV- infected ana HIV-uninfected patients. Clin Imaging 25:362–367PubMedCrossRef
25.
Schulz HG, Chrıstou A, Gursky S, Rother P (1986) Computerized tomography studies of normal morphology and volumetry of parenchymatous epigastric organs in humans. Anat Anz 162:1–12PubMed
26.
Sheikhazadi A, Sadr SS, Ghadyani MH, Taheri SK, Manouchehri AA, Nazparvar B, Mehrpour O, Ghorbani M (2010) Study of the normal internal organ weights in Tehran’s population. J Forensic Leg Med 17:78–83PubMedCrossRef
27.
Stefanovic AD, Masulovic D, Kostic J, Randjic K, Saranovic D (2012) CT volumetry of normal pancreas: correlation with the pancreatic diameters measurable by the cross-sectional imaging, and relationship with the gender, age, and body constitution. Surg Radiol Anat. doi:10.​1007/​s00276-012-0962-7
28.
Tanaka G, Nakahara Y, Nakazıma Y (1989) Japanese reference man 1988-IV. Studies on the weight and size of internal organs of normal Japanese. Nihon Igaku Hoshasen Gakkai Zasshi 49:344–364PubMed
29.
Westermark P, Wılander E (1978) The influence of amyloid deposits on the islet volume in maturity onset diabetes mellitus. Diabetologia 15:417–421PubMedCrossRef
30.
Williams AJK, Chau W, Callaway MP, Dayan CM (2007) Magnetic resonance imaging: a reliable method for measuring pancreatic volume in type 1 diabetes. Diabet Med 24:35–40PubMedCrossRef
31.
Zaidi E, Daly B (2006) CT and clinical features of acute diverticulitis in an urban US population: rising frequency in young obese adults. AJR 187:689–694PubMedCrossRef
Metadata
Title
Age-related volumetric changes in pancreas: a stereological study on computed tomography
Authors
Veli Caglar
Ahmet Songur
Murat Yagmurca
Murat Acar
Muhsin Toktas
Yucel Gonul
Publication date
01-12-2012
Publisher
Springer-Verlag
Published in
Surgical and Radiologic Anatomy / Issue 10/2012
Print ISSN: 0930-1038
Electronic ISSN: 1279-8517
DOI
https://doi.org/10.1007/s00276-012-0988-x

Other articles of this Issue 10/2012

Surgical and Radiologic Anatomy 10/2012 Go to the issue

Original Article

Morphological and functional asymmetry of the human recurrent laryngeal nerve

Anatomic Variations

Absence of the celiac trunk: case report using MDCT angiography

Original Article

Prestyloid compartment of the parapharyngeal space: a histological study using late-stage human fetuses

Erratum

Erratum to: Superior laryngeal nerve loop: patterns and surgical implications

Original Article

Compartments of the foot: topographic anatomy

Anatomic Variations

A keyhole-shaped sternal defect in an ancient human skeleton