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Published in: CardioVascular and Interventional Radiology 4/2019

01-04-2019 | Clinical Investigation

Gastric Embolization as Treatment for Overweight Patients; Efficacy and Safety

Authors: S. Elens, T. Roger, M. Elens, J. Rommens, A. Sarafidis, E. Capelluto, C. Delcour

Published in: CardioVascular and Interventional Radiology | Issue 4/2019

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Abstract

Objectives

The aim of this study was to evaluate the efficacy and safety of left gastric artery (LGA) embolization for the treatment of overweight patients who weren’t candidates for bariatric surgery.

Materials and Methods

We retrospectively collected data of 16 patients who underwent a selective embolization of the LGA. The mean body mass index (BMI) before intervention was 28.9 kg/m2 ± 2.5, and therefore, patients were not candidates for bariatric surgery in Belgium. The embolization was realized with 500–700 µm particles via the right common femoral artery approach. Before and following the intervention, an upper endoscopy was performed. Patient demographics, weight loss, hunger sensation and a satisfactory scale were reviewed.

Results

Between February 2015 and May 2017, 16 overweight patients were treated, one embolization was unsuccessful. Four (25%) patients were lost in follow-up. Nine (56%) patients showed early weight loss, one (6%) maintained his bodyweight and one (6%) patient underwent bariatric surgery 2 years after consultation. Only one (6%) patient had a gastric ulceration on control endoscopy. One (6%) patient ended in the intensive care unit for pancreatitis and gastric perforation. The mean weight loss was 8 kg ± 5.12, reducing their mean BMI to 25.5 ± 3.5. The hunger sensation was decreased, and patients were satisfied.

Conclusion

This is a preliminary study in an overweight population that appears to induce weight loss and appetite suppression. Larger studies are needed to confirm these preliminary findings.
Literature
1.
go back to reference Elder KA, Wolfe BM. Bariatric surgery: a review of procedures and outcomes. Gastroenterology. 2007;132(6):2253–71.CrossRefPubMed Elder KA, Wolfe BM. Bariatric surgery: a review of procedures and outcomes. Gastroenterology. 2007;132(6):2253–71.CrossRefPubMed
2.
go back to reference O’Rourke RW, Andrus J, Diggs BS, Scholz M, McConnell DB, Deveney CW. Perioperative morbidity associated with bariatric surgery: an academic center experience. Arch Surg. 2006;141(3):262–8.CrossRefPubMed O’Rourke RW, Andrus J, Diggs BS, Scholz M, McConnell DB, Deveney CW. Perioperative morbidity associated with bariatric surgery: an academic center experience. Arch Surg. 2006;141(3):262–8.CrossRefPubMed
3.
go back to reference Weiss CR, Gunn AJ, Kim CY, Paxton BE, Kraitchman DL, Arepally A. Bariatric embolization of the gastric arteries for the treatment of obesity. J Vasc Interv Radiol. 2015;26:613–24.CrossRefPubMedPubMedCentral Weiss CR, Gunn AJ, Kim CY, Paxton BE, Kraitchman DL, Arepally A. Bariatric embolization of the gastric arteries for the treatment of obesity. J Vasc Interv Radiol. 2015;26:613–24.CrossRefPubMedPubMedCentral
4.
go back to reference Arepally A, Barnett BP, Montgomery E, Patel TH. Catheter-directed gastric artery chemical embolization for modulation of systemic ghrelin levels in a porcine model: initial experience. Radiology. 2007;244(1):138–43.CrossRefPubMed Arepally A, Barnett BP, Montgomery E, Patel TH. Catheter-directed gastric artery chemical embolization for modulation of systemic ghrelin levels in a porcine model: initial experience. Radiology. 2007;244(1):138–43.CrossRefPubMed
5.
go back to reference Paxton BE, Kim CY, Alley CL, Crow JH, Balmadrid B, Keith CG, Kankotia RJ, Stinnett S, Arepally A. Bariatric embolization for suppression of the hunger hormone ghrelin in a porcine model. Radiology. 2013;266(2):471–9.CrossRefPubMed Paxton BE, Kim CY, Alley CL, Crow JH, Balmadrid B, Keith CG, Kankotia RJ, Stinnett S, Arepally A. Bariatric embolization for suppression of the hunger hormone ghrelin in a porcine model. Radiology. 2013;266(2):471–9.CrossRefPubMed
6.
go back to reference Diana M, Pop R, Beaujeux R, Dallemagne B, Halvax P, Schlagowski I, Liu YY, Diemunsch P, Geny B, Lindner V, Marescaux J. Embolization of arterial gastric supply in obesity (EMBARGO): an endovascular approach in the management of morbid obesity. Proof of the concept in the porcine model. Obes Surg. 2015;25(3):550–8.CrossRefPubMed Diana M, Pop R, Beaujeux R, Dallemagne B, Halvax P, Schlagowski I, Liu YY, Diemunsch P, Geny B, Lindner V, Marescaux J. Embolization of arterial gastric supply in obesity (EMBARGO): an endovascular approach in the management of morbid obesity. Proof of the concept in the porcine model. Obes Surg. 2015;25(3):550–8.CrossRefPubMed
7.
go back to reference Syed MI, Morar K, Shaikh A, Craig P, Khan O, Patel S. Khabiri H. Gastric artery embolization trial for the lessening of appetite nonsurgically (GET LEAN): six-Month preliminary data. J Vasc Interv Radiol. 2016;27(10):1502–8.CrossRefPubMed Syed MI, Morar K, Shaikh A, Craig P, Khan O, Patel S. Khabiri H. Gastric artery embolization trial for the lessening of appetite nonsurgically (GET LEAN): six-Month preliminary data. J Vasc Interv Radiol. 2016;27(10):1502–8.CrossRefPubMed
8.
go back to reference Kipshidze N, Archvadze A, Bertog S, Leon MB, Sievert H. Endovascular bariatrics: first in humans study of gastric artery embolization for weight loss, JACC. Cardiovasc Interv. 2015;8(12):1641–4.CrossRef Kipshidze N, Archvadze A, Bertog S, Leon MB, Sievert H. Endovascular bariatrics: first in humans study of gastric artery embolization for weight loss, JACC. Cardiovasc Interv. 2015;8(12):1641–4.CrossRef
9.
go back to reference Weiss CR, Akinwande O, Paudel K, Cheskin LJ, Holly B, Hong K, Fischman AM, Patel RS, Shin EJ, Steele KE, Moran TH, Kaiser K, Park A, Shade DM, Kraitchman DL, Arepally A. Clinical safety of bariatric arterial embolization: preliminary results of the BEAT obesity trial. Radiology. 2017;283:160914.CrossRef Weiss CR, Akinwande O, Paudel K, Cheskin LJ, Holly B, Hong K, Fischman AM, Patel RS, Shin EJ, Steele KE, Moran TH, Kaiser K, Park A, Shade DM, Kraitchman DL, Arepally A. Clinical safety of bariatric arterial embolization: preliminary results of the BEAT obesity trial. Radiology. 2017;283:160914.CrossRef
10.
go back to reference Vairavamurthya J, Cheskinb LJ, Kraitchmanc DL, Arepally A, Weiss CR. Current and cutting-edge interventions for the treatment of obese patients. Eur J Radiol. 2017;93:134–42.CrossRef Vairavamurthya J, Cheskinb LJ, Kraitchmanc DL, Arepally A, Weiss CR. Current and cutting-edge interventions for the treatment of obese patients. Eur J Radiol. 2017;93:134–42.CrossRef
11.
go back to reference Kim CY, Paxton BE, Weiss CR, Arepally A. Bariatric embolization for the treatment of obesity. Gastroint Interv. 2014;3(2):80–3.CrossRef Kim CY, Paxton BE, Weiss CR, Arepally A. Bariatric embolization for the treatment of obesity. Gastroint Interv. 2014;3(2):80–3.CrossRef
12.
13.
go back to reference Wadden TA, Butryn ML, Byrne KJ. Efficacy of lifestyle modification for long-term weight control. Obes Res. 2004;12(Suppl):151S–62S.CrossRefPubMed Wadden TA, Butryn ML, Byrne KJ. Efficacy of lifestyle modification for long-term weight control. Obes Res. 2004;12(Suppl):151S–62S.CrossRefPubMed
Metadata
Title
Gastric Embolization as Treatment for Overweight Patients; Efficacy and Safety
Authors
S. Elens
T. Roger
M. Elens
J. Rommens
A. Sarafidis
E. Capelluto
C. Delcour
Publication date
01-04-2019
Publisher
Springer US
Published in
CardioVascular and Interventional Radiology / Issue 4/2019
Print ISSN: 0174-1551
Electronic ISSN: 1432-086X
DOI
https://doi.org/10.1007/s00270-018-2130-x

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