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CardioVascular and Interventional Radiology
Published in: CardioVascular and Interventional Radiology 7/2017

01-07-2017 | Technical Note

A Novel External Carotid Arterial Sheath System for Intra-arterial Infusion Chemotherapy of Head and Neck Cancer

Authors: Noriko Ii, Nobukazu Fuwa, Yutaka Toyomasu, Akinori Takada, Miwako Nomura, Tomoko Kawamura, Hajime Sakuma, Yoshihito Nomoto

Published in: CardioVascular and Interventional Radiology | Issue 7/2017

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Abstract

Purpose

The purpose of this study was to describe a novel system for treating advanced head and neck cancer consisting of an external carotid arterial sheath (ECAS) and a microcatheter to inject drugs retrogradely into multiple feeding arteries through the superficial temporal artery (STA).

Materials and Methods

Four consecutive patients with head and neck cancer that had more than one feeding artery were enrolled in this study. The ECAS was made of polyurethane and surface-coated with heparin resin to prevent thrombus formation, allowing it to remain in place for a prolonged period of time. The ECAS was inserted through the STA, and its tip was placed between the maxillary artery and facial artery. The tumor-feeding arteries were selected using a hooked-shaped microcatheter through the ECAS.

Results

A total of 13 target arteries were selected in the four patients. The microcatheter inserted via the ECAS was used to catheterize ten arteries (five lingual arteries and five facial arteries). The remaining three lingual arteries were directly selected by the catheter without ECAS. All of the target arteries were able to be catheterized superselectively. The technical success rate was 100%. Vascular occlusion, which might have been caused by the ECAS, was observed in one patient. No neurologic toxicities occurred.

Conclusion

This ECAS system is a new approach for retrograde superselective intra-arterial chemotherapy that covers the entire tumor with anticancer drugs. It has the potential to increase the effectiveness of therapy for advanced head and neck cancer.

Level of Evidence

Level 4, Case Series.
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Metadata
Title
A Novel External Carotid Arterial Sheath System for Intra-arterial Infusion Chemotherapy of Head and Neck Cancer
Authors
Noriko Ii
Nobukazu Fuwa
Yutaka Toyomasu
Akinori Takada
Miwako Nomura
Tomoko Kawamura
Hajime Sakuma
Yoshihito Nomoto
Publication date
01-07-2017
Publisher
Springer US
Published in
CardioVascular and Interventional Radiology / Issue 7/2017
Print ISSN: 0174-1551
Electronic ISSN: 1432-086X
DOI
https://doi.org/10.1007/s00270-017-1635-z

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