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Published in: CardioVascular and Interventional Radiology 8/2016

01-08-2016 | Technical Note

Transcatheter Arterial Embolization with n-Butyl Cyanoacrylate for the Treatment of Acquired Uterine Vascular Malformations

Authors: Andrew C. Picel, Sonya J. Koo, Anne C. Roberts

Published in: CardioVascular and Interventional Radiology | Issue 8/2016

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Abstract

Purpose

The purpose of the study was to evaluate the technique and outcomes of transcatheter arterial embolization (TAE) with n-butyl cyanoacrylate (NBCA) for the treatment of acquired uterine arteriovenous malformations (AVMs).

Materials and methods

A retrospective review identified five women treated for suspected acquired uterine AVMs with TAE at our institution. Four women (80 %) presented with heavy or intermittent vaginal bleeding after obstetric manipulation. One woman (20 %) was treated for an incidental AVM discovered on ultrasound after an uncomplicated cesarean section. Three women underwent one embolization procedure and two women required two procedures. Embolization material included NBCA in six procedures (80 %) and gelatin sponge in one procedure (20 %).

Results

Embolization resulted in angiographic stasis of flow in all seven procedures. Four women (80 %) presented with vaginal bleeding which was improved after treatment. One woman returned 24 days after unilateral embolization with recurrent bleeding, which resolved after retreatment. One woman underwent two treatments for an asymptomatic lesion identified on ultrasound. There were no major complications. Three women (60 %) experienced mild postembolization pelvic pain that was controlled with non-steroidal anti-inflammatory drugs. Three women (60 %) had pregnancies and deliveries after embolization.

Conclusions

TAE is a safe alternative to surgical therapy for acquired uterine AVMs with the potential to maintain fertility. Experience from this case series suggests that NBCA provides predictable and effective occlusion.
Literature
1.
go back to reference O’Brien P, Neyastani A, Buckley AR, Chang SD, Legiehn GM. Uterine arteriovenous malformations: from diagnosis to treatment. J Ultrasound Med. 2006;25:1387–92.PubMed O’Brien P, Neyastani A, Buckley AR, Chang SD, Legiehn GM. Uterine arteriovenous malformations: from diagnosis to treatment. J Ultrasound Med. 2006;25:1387–92.PubMed
2.
go back to reference Polat P, Suma S, Kantarcy M, Alper F, Levent A. Color Doppler US in the evaluation of uterine vascular abnormalities. Radiographics. 2002;22:47–53.CrossRefPubMed Polat P, Suma S, Kantarcy M, Alper F, Levent A. Color Doppler US in the evaluation of uterine vascular abnormalities. Radiographics. 2002;22:47–53.CrossRefPubMed
3.
go back to reference Ghai S, Rajan DK, Asch MR, Muradali D, Simons ME, TerBrugge KG. Efficacy of embolization in traumatic uterine vascular malformations. J Vasc Interv Radiol. 2003;14:1401–8.CrossRefPubMed Ghai S, Rajan DK, Asch MR, Muradali D, Simons ME, TerBrugge KG. Efficacy of embolization in traumatic uterine vascular malformations. J Vasc Interv Radiol. 2003;14:1401–8.CrossRefPubMed
4.
go back to reference Kwon JH, Kim GS. Obstetric iatrogenic arterial injuries of the uterus: diagnosis with US and treatment with transcatheter arterial embolization. Radiographics. 2002;22:35–46.CrossRefPubMed Kwon JH, Kim GS. Obstetric iatrogenic arterial injuries of the uterus: diagnosis with US and treatment with transcatheter arterial embolization. Radiographics. 2002;22:35–46.CrossRefPubMed
5.
go back to reference Vogelzang RL, Nemcek AA Jr, Skrtic Z, Gorrell J, Lurain JR. Uterine arteriovenous malformations: primary treatment with therapeutic embolization. J Vasc Interv Radiol. 1991;2:517–22.CrossRefPubMed Vogelzang RL, Nemcek AA Jr, Skrtic Z, Gorrell J, Lurain JR. Uterine arteriovenous malformations: primary treatment with therapeutic embolization. J Vasc Interv Radiol. 1991;2:517–22.CrossRefPubMed
6.
go back to reference Lim AK, Agarwal R, Seckl MJ, Newlands ES, Barrett NK, Mitchell AW. Embolization of bleeding residual uterine vascular malformations in patients with treated gestational trophoblastic tumors. Radiology. 2002;222:640–4.CrossRefPubMed Lim AK, Agarwal R, Seckl MJ, Newlands ES, Barrett NK, Mitchell AW. Embolization of bleeding residual uterine vascular malformations in patients with treated gestational trophoblastic tumors. Radiology. 2002;222:640–4.CrossRefPubMed
7.
go back to reference Grivell RM, Reid KM, Mellor A. Uterine arteriovenous malformations: a review of the current literature. Obstet Gynecol Surv. 2005;60:761–7.CrossRefPubMed Grivell RM, Reid KM, Mellor A. Uterine arteriovenous malformations: a review of the current literature. Obstet Gynecol Surv. 2005;60:761–7.CrossRefPubMed
8.
go back to reference Maleux G, Timmerman D, Heye S, Wilms G. Acquired uterine vascular malformations: radiological and clinical outcome after transcatheter embolotherapy. Eur Radiol. 2006;16:299–306.CrossRefPubMed Maleux G, Timmerman D, Heye S, Wilms G. Acquired uterine vascular malformations: radiological and clinical outcome after transcatheter embolotherapy. Eur Radiol. 2006;16:299–306.CrossRefPubMed
9.
go back to reference Lin AC, Hung YC, Huang LC, Chiu TH, Ho M. Successful treatment of uterine arteriovenous malformation with percutaneous embolization. Taiwan J Obstet Gynecol. 2007;46:60–3.CrossRefPubMed Lin AC, Hung YC, Huang LC, Chiu TH, Ho M. Successful treatment of uterine arteriovenous malformation with percutaneous embolization. Taiwan J Obstet Gynecol. 2007;46:60–3.CrossRefPubMed
10.
go back to reference Peitsidis P, Manolakos E, Tsekoura V, Kreienberg R, Schwentner L. Uterine arteriovenous malformations induced after diagnostic curettage: a systematic review. Arch Gynecol Obstet. 2011;284:1137–51.CrossRefPubMed Peitsidis P, Manolakos E, Tsekoura V, Kreienberg R, Schwentner L. Uterine arteriovenous malformations induced after diagnostic curettage: a systematic review. Arch Gynecol Obstet. 2011;284:1137–51.CrossRefPubMed
11.
go back to reference Timmerman D, Wauters J, Van Calenbergh S, Van Schoubroeck D, Maleux G, Van Den Bosch T, et al. Color Doppler imaging is a valuable tool for the diagnosis and management of uterine vascular malformations. Ultrasound Obstet Gynecol. 2003;21:570–7.CrossRefPubMed Timmerman D, Wauters J, Van Calenbergh S, Van Schoubroeck D, Maleux G, Van Den Bosch T, et al. Color Doppler imaging is a valuable tool for the diagnosis and management of uterine vascular malformations. Ultrasound Obstet Gynecol. 2003;21:570–7.CrossRefPubMed
12.
go back to reference Lee TY, Kim SH, Lee HJ, Kim MJ, Lee SK, Kim YH, et al. Ultrasonographic indications for conservative treatment in pregnancy-related uterine arteriovenous malformations. Acta Radiol. 2014;55(9):1145–52.CrossRefPubMed Lee TY, Kim SH, Lee HJ, Kim MJ, Lee SK, Kim YH, et al. Ultrasonographic indications for conservative treatment in pregnancy-related uterine arteriovenous malformations. Acta Radiol. 2014;55(9):1145–52.CrossRefPubMed
13.
go back to reference Molvi SN, Dash K, Rastogi H, Khanna SB. Transcatheter embolization of uterine arteriovenous malformation: report of 2 cases and review of the literature. J Minim Invasive Gynecol. 2011;18:812–9.CrossRefPubMed Molvi SN, Dash K, Rastogi H, Khanna SB. Transcatheter embolization of uterine arteriovenous malformation: report of 2 cases and review of the literature. J Minim Invasive Gynecol. 2011;18:812–9.CrossRefPubMed
14.
go back to reference Levy-Zaubermann Y, Capmas P, Legendre G, Fernandez H. Laparoscopic management of uterine arteriovenous malformations via occlusion of internal iliac arteries. J Minim Invasive Gynecol. 2012;19:785–8.CrossRefPubMed Levy-Zaubermann Y, Capmas P, Legendre G, Fernandez H. Laparoscopic management of uterine arteriovenous malformations via occlusion of internal iliac arteries. J Minim Invasive Gynecol. 2012;19:785–8.CrossRefPubMed
15.
go back to reference Kim T, Shin JH, Kim J, Yoon HK, Ko GY, Gwon DI, et al. Management of bleeding uterine arteriovenous malformation with bilateral uterine artery embolization. Yonsei Med J. 2014;55:367–73.CrossRefPubMedPubMedCentral Kim T, Shin JH, Kim J, Yoon HK, Ko GY, Gwon DI, et al. Management of bleeding uterine arteriovenous malformation with bilateral uterine artery embolization. Yonsei Med J. 2014;55:367–73.CrossRefPubMedPubMedCentral
16.
go back to reference Gopal M, Goldberg J, Klein TA, Fossum GT. Embolization of a uterine arteriovenous malformation followed by a twin pregnancy. Obstet Gynecol. 2003;102:696–8.PubMed Gopal M, Goldberg J, Klein TA, Fossum GT. Embolization of a uterine arteriovenous malformation followed by a twin pregnancy. Obstet Gynecol. 2003;102:696–8.PubMed
17.
go back to reference Garner EI, Meyerovitz M, Goldstein DP, Berkowitz RS. Successful term pregnancy after selective arterial embolization of symptomatic arteriovenous malformation in the setting of gestational trophoblastic tumor. Gynecol Oncol. 2003;88:69–72.CrossRefPubMed Garner EI, Meyerovitz M, Goldstein DP, Berkowitz RS. Successful term pregnancy after selective arterial embolization of symptomatic arteriovenous malformation in the setting of gestational trophoblastic tumor. Gynecol Oncol. 2003;88:69–72.CrossRefPubMed
18.
go back to reference Soyer P, Dohan A, Dautry R, Guerrache Y, Ricbourg A, Gayat E, et al. Transcatheter arterial embolization for postpartum hemorrhage: indications, technique, results, and complications. Cardiovasc Interv Radiol. 2015;38(5):1068–81.CrossRef Soyer P, Dohan A, Dautry R, Guerrache Y, Ricbourg A, Gayat E, et al. Transcatheter arterial embolization for postpartum hemorrhage: indications, technique, results, and complications. Cardiovasc Interv Radiol. 2015;38(5):1068–81.CrossRef
19.
go back to reference Nasu K, Nishida M, Yoshimatsu J, Narahara H. Ectopic pregnancy after successful treatment with percutaneous transcatheter uterine arterial embolization for congenital uterine arteriovenous malformation: a case report. Arch Gynecol Obstet. 2008;278:171–2.CrossRefPubMed Nasu K, Nishida M, Yoshimatsu J, Narahara H. Ectopic pregnancy after successful treatment with percutaneous transcatheter uterine arterial embolization for congenital uterine arteriovenous malformation: a case report. Arch Gynecol Obstet. 2008;278:171–2.CrossRefPubMed
20.
go back to reference Yang JJ, Xiang Y, Wan XR, Yang XY. Diagnosis and management of uterine arteriovenous fistulas with massive vaginal bleeding. Int J Gynaecol Obstet. 2005;89:114–9.CrossRefPubMed Yang JJ, Xiang Y, Wan XR, Yang XY. Diagnosis and management of uterine arteriovenous fistulas with massive vaginal bleeding. Int J Gynaecol Obstet. 2005;89:114–9.CrossRefPubMed
21.
go back to reference Badawy SZ, Etman A, Singh M, Murphy K, Mayelli T, Philadelphia M. Uterine artery embolization: the role in obstetrics and gynecology. Clin Imaging. 2001;25:288–95.CrossRefPubMed Badawy SZ, Etman A, Singh M, Murphy K, Mayelli T, Philadelphia M. Uterine artery embolization: the role in obstetrics and gynecology. Clin Imaging. 2001;25:288–95.CrossRefPubMed
22.
go back to reference Wang Z, Chen J, Shi H, Zhou K, Sun H, Li X, et al. Efficacy and safety of embolization in iatrogenic traumatic uterine vascular malformations. Clin Radiol. 2012;67:541–55.CrossRefPubMed Wang Z, Chen J, Shi H, Zhou K, Sun H, Li X, et al. Efficacy and safety of embolization in iatrogenic traumatic uterine vascular malformations. Clin Radiol. 2012;67:541–55.CrossRefPubMed
23.
go back to reference Palmaz JC, Newton TH, Reuter SR, Bookstein JJ. Particulate intraarterial embolization in pelvic arteriovenous malformations. AJR Am J Roentgenol. 1981;137:117–22.CrossRefPubMed Palmaz JC, Newton TH, Reuter SR, Bookstein JJ. Particulate intraarterial embolization in pelvic arteriovenous malformations. AJR Am J Roentgenol. 1981;137:117–22.CrossRefPubMed
24.
go back to reference No authors listed. Fatal nontarget embolization via an intrafibroid arterial venous fistula during uterine fibroid embolization. J Vasc Interv Radiol. 2009;20(3):419–20.CrossRef No authors listed. Fatal nontarget embolization via an intrafibroid arterial venous fistula during uterine fibroid embolization. J Vasc Interv Radiol. 2009;20(3):419–20.CrossRef
25.
go back to reference Vaidya S, Tozer KR, Chen J. An overview of embolic agents. Semin Interv Radiol. 2008;25:204–15.CrossRef Vaidya S, Tozer KR, Chen J. An overview of embolic agents. Semin Interv Radiol. 2008;25:204–15.CrossRef
26.
go back to reference Eddleman CS, Welch BG, Vance AZ, Rickert KL, White JA, Pride GL, et al. Endovascular coils: properties, technical complications, and salvage techniques. J Neurointerv Surg. 2013;5(2):104–9.CrossRefPubMed Eddleman CS, Welch BG, Vance AZ, Rickert KL, White JA, Pride GL, et al. Endovascular coils: properties, technical complications, and salvage techniques. J Neurointerv Surg. 2013;5(2):104–9.CrossRefPubMed
27.
go back to reference Enokizono M, Sakamoto I, Hayashi H, Sueyoshi E, Uetani M. Use of n-butyl cyanoacrylate in abdominal and pelvic embolotherapy: indications and techniques, complications, and their management. Jpn J Radiol. 2012;30:377–85.CrossRefPubMed Enokizono M, Sakamoto I, Hayashi H, Sueyoshi E, Uetani M. Use of n-butyl cyanoacrylate in abdominal and pelvic embolotherapy: indications and techniques, complications, and their management. Jpn J Radiol. 2012;30:377–85.CrossRefPubMed
28.
go back to reference Kanematsu M, Watanabe H, Kondo h, et al. Postpartum hemorrhage in coagulopathic patients: preliminary experience with uterine arterial embolization and N-butyl cyanoacrylate. J Vasc Interv Radiol. 2011;22:1773–6.CrossRefPubMed Kanematsu M, Watanabe H, Kondo h, et al. Postpartum hemorrhage in coagulopathic patients: preliminary experience with uterine arterial embolization and N-butyl cyanoacrylate. J Vasc Interv Radiol. 2011;22:1773–6.CrossRefPubMed
29.
go back to reference Woodhams R, Ogasawara G, Ishida K, Fujii K, Yamane T, Nishimaki H, et al. Successful treatment of acquired uterine arterial venous malformation using N-butyl-2-cyanoacrylate under balloon occlusion. Acta Radiol Short Rep. 2014;3(8):1–6. Woodhams R, Ogasawara G, Ishida K, Fujii K, Yamane T, Nishimaki H, et al. Successful treatment of acquired uterine arterial venous malformation using N-butyl-2-cyanoacrylate under balloon occlusion. Acta Radiol Short Rep. 2014;3(8):1–6.
30.
go back to reference Loffroy R. Glubran2®, Histoacryl®, or Trufill®: which cyanoacrylate glue for endovascular use? Diagn Interv Imaging. 2016;97(1):119.CrossRefPubMed Loffroy R. Glubran2®, Histoacryl®, or Trufill®: which cyanoacrylate glue for endovascular use? Diagn Interv Imaging. 2016;97(1):119.CrossRefPubMed
Metadata
Title
Transcatheter Arterial Embolization with n-Butyl Cyanoacrylate for the Treatment of Acquired Uterine Vascular Malformations
Authors
Andrew C. Picel
Sonya J. Koo
Anne C. Roberts
Publication date
01-08-2016
Publisher
Springer US
Published in
CardioVascular and Interventional Radiology / Issue 8/2016
Print ISSN: 0174-1551
Electronic ISSN: 1432-086X
DOI
https://doi.org/10.1007/s00270-016-1328-z

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