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CardioVascular and Interventional Radiology
Published in: CardioVascular and Interventional Radiology 3/2015

01-06-2015 | Review/State of the Art

Type 2 Endoleaks Post-EVAR: Current Evidence for Rupture Risk, Intervention and Outcomes of Treatment

Authors: Raymond Chung, Robert A. Morgan

Published in: CardioVascular and Interventional Radiology | Issue 3/2015

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Abstract

Type 2 endoleaks (EL2) are the most commonly encountered endoleaks following EVAR. Despite two decades of experience, there remains considerable variation in the management of EL2 with controversies ranging from if to treat, when to treat and how to treat. Here, we summarise the available evidence, describe the treatment techniques available and offer guidelines for management.
Literature
1.
Timaran CH, Ohki T, Rhee SJ, Veith FJ, Gargiulo NJ, Toriumi H, Malas MB, Suggs WD, Wain RA, Lipsitz EC (2004) Predicting aneurysm enlargement in patients with persistent type II endoleaks. J Vasc Surg 39:1157–1162CrossRefPubMed
2.
Nevala T, Biancari F, Manninen H, Aho PS, Matsi P, Mäkinen K, Roth WD, Ylönen K, Lepäntalo M, Perälä J (2010) Type II endoleak after endovascular repair of abdominal aortic aneurysm: effectiveness of embolization. Cardiovasc Interv Radiol 33(2):278–284CrossRef
3.
Warrier R, Miller R, Bond R, Robertson IK, Hewitt P, Scott A (2008) Risk factors for type II endoleaks after endovascular repair of abdominal aortic aneurysms. ANZ J Surg 78(1–2):61–63CrossRefPubMed
4.
Baum RA, Carpenter JP, Tuite CM, Velazquez OC, Soulen MC, Barker CF, Golden MA, Pyeron AM, Fairman RM (2000) Diagnosis and treatment of inferior mesenteric arterial endoleaks after endovascular repair of abdominal aortic aneurysms. Radiology 215:409–413CrossRefPubMed
5.
Rhee SJ, Ohki T, Veith FJ, Kurvers H (2003) Current status of management of type II endoleaks after endovascular repair of abdominal aortic aneurysms. Ann Vasc Surg 17:335–344CrossRefPubMed
6.
Jones JE, Atkins MD, Brewster DC, Chung TK, Kwolek CJ, LaMuraglia GM, Hodgman TM, Cumbria RP (2007) Persistent type 2 endoleak after endovascular repair of abdominal aortic aneurysm is associated with adverse late outcomes. J Vasc Surg 46:1–8CrossRefPubMed
7.
Arko FR, Rubin GD, Johnson BL, Hill BB, Fogarty TJ, Zarins CK (2001) Type-II endoleaks following endovascular AAA repair: preoperative predictors and long-term effects. J Endovasc Ther 8:503–510CrossRefPubMed
8.
Marrewijk CV, Fransen G, Laheij RJF, Harris PL, Buth J (2004) EUROSTAR collaborators. Is a type II endoleak after EVAR a harbinger of risk? Causes and outcome of open conversion and aneurysm rupture during follow-up. Eur J Vasc Endovasc Surg 27:128–137CrossRefPubMed
9.
El Batti S, Cochennec F, Roudot-Thoraval F, Becquemin JP (2013) Type II endoleaks after endovascular repair of abdominal aortic aneurysm are not always a benign condition. J Vasc Surg 57:1291–1298CrossRefPubMed
10.
Sadek M, Dexter DJ, Rockman CB, Hoang H, Mussa FF, Cayne NS, Jacobowitz GR, Veith FJ, Adelman MA, Maldonado TS (2013) Preoperative relative abdominal aortic aneurysm thrombus burden predicts endoleak and sac enlargement after endovascular aneurysm repair. Ann Vasc Surg 27(8):1036–1041CrossRefPubMed
11.
Wild JB, Dattani N, Stather P, Bown MJ, Sayers RD, Choke E (2013) Effect of anticoagulation and antiplatelet therapy on incidence of endoleaks and sac size expansions after endovascular aneurysm repair. Ann Vasc Surg 28(3):554–559CrossRefPubMed
12.
Fairman RM, Carpenter JP, Baum RA, Larson RA, Golden MA, Barker CF, Mitchell ME, Velazguez OC (2002) Potential impact of therapeutic warfarin treatment on type II endoleaks and sac shrinkage rates on midterm follow-up examination. J Vasc Surg 35(4):679–685CrossRefPubMed
13.
Muthu C, Maani J, Plank LD, Holden A, Hill A (2007) Strategies to reduce the rate of type II endoleaks: routine intraoperative embolization of the inferior mesenteric artery and thrombin injection into the aneurysm sac. J Endovasc Ther 14:661–668CrossRefPubMed
14.
Gould DA, McWilliams RG, Edwards RD et al (2001) Aortic side branch embolization before endovascular aneurysm repair: incidence of type II endoleak. J Vasc Interv Radiol 15:337–341CrossRef
15.
Bonvini R, Alerci M, Antonucci F, Tutta P, Wyttenbach R, Bogen M, Pelloni A, von Segesser L, Gallino A (2003) Preoperative embolization of collateral side branches: a valid means to reduce type II endoleaks after endovascular AAA repair. J Endovasc Ther 10:227–232CrossRefPubMed
16.
Ronsivalle S, Faresin F, Franz F, Rettore C, Zanchetta M, Olivieri A (2010) Aneurysm sac “thrombization” and stabilization in EVAR: a technique to reduce the risk of type II endoleak. J Endovasc Ther 17:517–524CrossRefPubMed
17.
Sheehan MK, Hagino RT, Canby E, Wholey MH, Postoak D, Suri R, Toursarkissian B (2006) Type 2 endoleaks after abdominal aortic aneurysm stent grafting with systematic mesenteric and lumbar coil embolization. Ann Vasc Surg 20(4):458–463CrossRefPubMed
18.
Ward TJ, Cohen S, Fischman AM, Kim E, Nowakowski FS, Ellozy SH, Faries PL, Marin ML, Lookstein RA (2013) Preoperative inferior mesenteric artery embolization before endovascular aneurysm repair: decreased incidence of type II endoleak and aneurysm sac enlargement with 24-month follow-up. J Vasc Interv Radiol 24(1):49–55CrossRefPubMed
19.
Alerci M, Giamboni A, Wyttenbach R, Porretta AP, Antonucci F, Bogen M, Toderi M, Guerra A, Sartori F, Tutta P, Inglese L, Limoni C, Gallino A, Segesser LKV (2013) Endovascular abdominal aneurysm repair and impact of systematic preoperative embolization of collateral arteries: endoleak analysis and long-term follow-up. J Endovasc Ther 20:663–671CrossRefPubMed
20.
Gelfand DV, White GH, Wilson SE (2006) Clinical significance of type II endoleak after endovascular repair of abdominal aortic aneurysm. Ann Vasc Surg 20(1):69–74CrossRefPubMed
21.
Parent FN, Meier GH, Godziachvili V, LeSar CJ, Parker FM, Carter KA, Gayle RG, DeMasi RJ, Marcinczyk MJ, Gregory RT (2002) The incidence and natural history of type I and II endoleak: a 5-year follow-up assessment with color duplex ultrasound scan. J Vasc Surg 35:474–481CrossRefPubMed
22.
Marchiori A, Ristow AV, Guimaraes M, Schonholz C, Uflacker R (2011) Predictive factors for the development of type II endoleaks. J Endovasc Ther 18:299–305CrossRefPubMed
23.
Marrewijk CV, Buth J, Harris PL, Norgren L, Nevelsteen A, Wyatt MG (2002) Significance of endoleaks after endovascular repair of abdominal aortic aneurysms: the EUROSTAR experience. J Vasc Surg 35:461–473CrossRefPubMed
24.
Ferrari M, Sardella SG, Berchiolli R, Adami D, Vignali C, Napoli V, Serino F (2005) Surgical treatment of persistent type 2 endoleaks, with increase of the aneurysm sac: indications and technical notes. Eur J Vasc Endovasc Surg 29:43–46CrossRefPubMed
25.
Greenhalgh RM (2010) The United Kingdom EVAR trial investigators. Endovascular versus open repair of abdominal aortic aneurysm. N Engl J Med 362:1863–1871CrossRefPubMed
26.
Wyss TR, Brown LC, Powell JT, Greenhalgh RM (2010) Rate and predictability of graft rupture after endovascular and open aortic aneurysm repair: data from the EVAR trials. Ann Surg 252:805–812CrossRefPubMed
27.
Sidloff DA, Stather PW, Choke E, Bown MJ, Sayers RD (2013) Type II endoleak after endovascular aneurysm repair. Br J Surg 100(10):1262–1270CrossRefPubMed
28.
Nolz R, Teufelsbauer H, Asenbaum U, Bietzke D, Funovics M, Wibner A, Plank C, Prusa AM, Lammer J, Schoder M (2012) Type II endoleaks after endovascular repair of abdominal aortic aneurysms: fate of the aneurysm sac and neck changes during follow-up. J Endovasc Ther 19:193–199CrossRefPubMed
29.
Wilmot A, Stavropoulous SW (2007) Embolization of a recurrent type 2 endoleak using the liquid embolic n-butyl cyanoacrylate. Semin Interv Radiol 24:38–42CrossRef
30.
Barbiero G, Baratto A, Ferro F, Dall’Acqua J, Fittà C, Miotto D (2008) Strategies of endoleak management following endoluminal treatment of abdominal aortic aneurysms in 95 patients: how, when and why. Radiol Med 113(7):1029–1042CrossRefPubMed
31.
Buth J, Harris PL, Van Marrewijk C, Fransen G (2003) Endoleaks during follow-up after endovascular repair of abdominal aortic aneurysm. Are they all dangerous? J Cardiovasc Surg 44(4):559–566
32.
Mandziak DM, Stanley BM, Foreman RK, Walsh JA, Burnett JR (2004) Outcome of endoleak following endoluminal abdominal aortic aneurysm repair. ANZ J Surg 74(12):1039–1042CrossRefPubMed
33.
Rayt HS, Sandford RM, Salem M, Bown MJ, London NJ, Sayers RD (2009) Conservative management of type 2 endoleaks is not associated with increased risk of aneurysm rupture. Eur J Vasc Endovasc Surg 38:718–723CrossRefPubMed
34.
Baum RA, Carpenter JP, Cope C, Golden MA, Velazquez OC, Neschis DG et al (2001) Aneurysm sac pressure measurements after endovascular repair of abdominal aortic aneurysms. J Vasc Surg 33:32–41CrossRefPubMed
35.
Görich J, Rilinger N, Sokiranski R, Krämer S, Schütz A, Sunder-Plassmann L, Pamler R (2000) Embolization of type II endoleaks fed by the inferior mesenteric artery: using the superior mesenteric artery approach. J Endovasc Ther 7:297–301CrossRefPubMed
36.
Schurink GW, Aarts NJ, Wilde J, van Baalen JM, Chuter TA, Schultze Kohl LJ et al (1998) Endoleakage after stent-graft treatment of abdominal aneurysm. Implications on pressure and imaging-an in vitro study. J Vasc Surg 28:234–241CrossRefPubMed
37.
Li Z, Kleinsteuer C (2006) Computational analysis of type II endoleaks in a stented abdominal aortic aneurysm model. J Biomech 39:2573–2582CrossRefPubMed
38.
Knowles M, Pellisar T, Murphy EH, Stanely GA, Hashmi AF, Arko Z, Arko FR III (2011) In vitro analysis of type II endoleaks and aneurysm sac pressurization on longitudinal stent-graft displacement. J Endovasc Ther 18:601–606CrossRefPubMed
39.
Karthikesalingam A, Thrumurthy SGH, Jackson D, Sayers RD, Loftus IM, Thompson MM, Holt PJ (2012) Current evidence is insufficient to define an optimal threshold for intervention in isolated type II endoleak after endovascular aneurysm repair. J Endovasc Ther 19(2):200–208CrossRefPubMed
40.
Lawrence-Brown MM, Sun Z, Semmens JB, Liffman K, Šutalo ID, Hartley DB (2009) Type II endoleaks: when is Intervention Indicated and What Is the Index of Suspicion for Types I or III? J Endovasc Ther 16(Suppl 1):106–118
41.
Steinmetz E, Rubin BG, Sanchez LA, Choi ET, Geraghty PJ, Baty J, Thompson RW, Flye MW, Hovsepian DM, Picus D, Sicard GA (2004) Type II endoleak after endovascular abdominal aortic aneurysm repair: a conservative approach with selective intervention is safe and cost-effective. J Vasc Surg 39:306–313CrossRefPubMed
42.
Buth J, Harris PL, van Marrewijk C, Fransen G (2003) The significance and management of different types of endoleaks. Semin Vasc Surg 16(2):95–102CrossRefPubMed
43.
Abularrage CJ, Patel VI, Conrad MF, Schneider EB, Cambria RP, Kwolek CJ (2012) Improved results using Onyx glue for the treatment of persistent type 2 endoleak after endovascular aneurysm repair. J Vasc Surg 56:630–636CrossRefPubMed
44.
Stavropoulos SW, Kim H, Clark TW, Fairman RM, Belazquez O, Carpenter JP (2005) Embolization of type 2 endoleaks after endovascular repair of abdominal aortic aneurysms with use of cyanoacrylate with or without coils. J Vasc Interv Radiol 16(6):857–861CrossRefPubMed
45.
Boks SS, Andhyiswara T, de Smet AA, Vroegindeweij D (2005) Ultrasound-guided percutaneous transabdominal treatment of a type 2 endoleak. Cardiovasc Interv Radiol 28(4):526–529CrossRef
46.
Martin ML, Dolmatch BL, Fry PD, Machan LS (2001) Treatment of type II endoleaks with Onyx. J Vasc Interv Radiol 12(5):629–632CrossRefPubMed
47.
Schmid R, Gurke L, Aschwanden M, Stierli P, Jacob AL (2002) CT-guided percutaneous embolization of a lumbar artery maintaining a type II endoleak. J Endovasc Ther 9:198–202PubMed
48.
Scali ST, Vlada A, Chang CK, Beck AW (2013) Transcaval embolization as an alternative technique for the treatment of type II endoleak after endovascular aortic aneurysm repair. J Vasc Surg 57:869–874CrossRefPubMedCentralPubMed
49.
van Bindsbergen L, Braak SJ, van Strijen MJ, de Vries JP (2010) Type II endoleak embolization after endovascular abdominal aortic aneurysm repair with use of real-time three-dimensional fluoroscopic needle guidance. J Vasc Interv Radiol 21(9):1443–1447CrossRefPubMed
50.
Katada Y, Kondo S, Takahashi S, Okita Y, Kagoshima A, Rokkaku K, Nozaki M (2013) Direct percutaneous puncture embolization of type II endoleaks using a coaxial technique. J Endovasc Ther 20(1):34–38CrossRefPubMed
51.
Massis K, Carson WG III, Rozas A, Patel V, Zwiebel B (2012) Treatment of type II endoleaks with ethylene-vinyl-alcohol copolymer (Onyx). Vasc Endovasc Surg 46(3):251–257CrossRef
52.
Coppi G, Saitta G, Coppi G, Gennai S, Lauricella A, Silingardi R (2014) Transealing: a novel and simple technique for embolization of type 2 endoleaks through direct sac access from the distal stent-graft landing zone. Eur J Vasc Endovasc Surg 47(4):394–401CrossRefPubMed
53.
Quinones-Baldrich W, Levin ES, Lew W, Barleben A (2014) Intraprocedural and postprocedural perigraft arterial sac embolization (PASE) for endoleak treatment. J Vasc Surg 59(2):538–541CrossRefPubMed
54.
Faries PL, Cadot H, Agarwal G, Kent KC, Hollier LH, Marin ML (2003) Management of endoleak after endovascular aneurysm repair: cuffs, coils, and conversion. J Vasc Surg 37:1155–1161CrossRefPubMed
55.
Haulon S, Tyazi A, Willoteaux S, Koussa M, Lions C, Beregi JP (2001) Embolization of type II endoleaks after aortic stent-graft implantation: technique and immediate results. J Vasc Surg 34:600–605CrossRefPubMed
56.
Bosiers MJ, Schwindt A, Donas KP, Torsello G (2013) Midterm results of the transarterial use of Onyx in the treatment of persisting type II endoleaks after EVAR. J Cardiovasc Surg 54(4):469–475
57.
Müller-Wille R, Wohlgemuth WA, Heiss P, Wiggermann P, Güntner O, Schreyer AG, Hoffstetter P, Stroszczynski C, Zorger N (2013) Transarterial embolization of type II endoleaks after EVAR: the role of ethylene vinyl alcohol copolymer (Onyx). Cardiovasc Interv Radiol 36(5):1288–1295CrossRef
58.
Funaki B, Birouti N, Zangan SM, Ha TGV, Lorenz JM, Navuluri R, Skelly CL, Leef JA (2012) Evaluation and treatment of suspected type II endoleaks in patients with enlarging abdominal aortic aneurysms. J Vasc Interv Radiol 23:866–872CrossRefPubMedCentralPubMed
59.
Sheehan MK, Barbato J, Compton CN, Zajko A, Rhee R, Makaroun MS (2004) Effectiveness of coiling in the treatment of endoleaks after endovascular repair. J Vasc Surg 40:430–434CrossRefPubMed
60.
Hongo N, Kiyosue H, Shuto R, Kamei N, Miyamoto S, Tanoue S, Mori H (2014) Double coaxial microcatheter technique for transarterial aneurysm sac embolization of type II endoleaks after endovascular abdominal aortic repair. J Vasc Interv Radiol 25(5):709–716CrossRefPubMed
61.
Sarac TP, Gibbons C, Vargas L, Liu J, Srivastava S, Bena J, Mastracci T, Kashyap VS, Clair D (2012) Long-term follow-up of type II endoleak embolization reveals the need for close surveillance. J Vasc Surg 55:33–40CrossRefPubMed
62.
Gallagher KA, Ravin RA, Meltzer AJ, Khan MA, Coleman DM, Graham AR, Aiello F, Shrikhande G, Connolly PH, Dayal R, Karwowski JK (2012) Midterm outcomes after treatment of type II endoleaks associated with aneurysm sac expansion. J Endovasc Ther 19:182–192CrossRefPubMed
63.
Kasirajan K, Matteson B, Marek JM, Langsfeld M (2003) Technique and results of transfemoral superselective coil embolization of type II lumbar endoleak. J Vasc Surg 38:61–66CrossRefPubMed
64.
Jouhannet C, Alsac J-M, Julia P, Sapoval M, El Batti S, Di Primio M, Fabiani JN (2014) Reinterventions for type 2 endoleaks with enlargement of the aneurismal sac after endovascular treatment of abdominal aortic aneurysms. Ann Vasc Surg 28(1):192–200CrossRefPubMed
65.
Rial R, Serrano FJ, Vega M, Rodriguez R, Martin A, Mendez J, Mendez R, Santos E, Gallego J (2004) Treatment of type II endoleaks after endovascular repair of abdominal aortic aneurysms: translumbar puncture and injection of thrombin into the aneurysm sac. Eur J Vasc Endovasc Surg 27:333–335CrossRefPubMed
66.
Uthoff H, Katzen BT, Gandhi R, Peña CS, Benenati JF, Geisbüsch P (2012) Direct percutaneous sac injection for postoperative endoleak treatment after endovascular aortic aneurysm repair. J Vasc Surg 56:965–972CrossRefPubMed
67.
Khaja, Park AW, Swee W, Evans AJ, Fritz Angle J, Turba UC, Sabri SS, Matusomoto AH (2013) Treatment of type II endoleak using Onyx with long-term imaging follow-up. Cardiovasc Interv Radiol 37(3):613–622CrossRef
68.
Baum RA, Carpenter JP, Golden MA, Velazquez OC, Clark TW, Stavropoulous SW, Cope C, Fairman RM (2002) Treatment of type 2 endoleaks after endovascular repair of abdominal aortic aneurysms: comparison of transarterial and translumbar techniques. J Vasc Surg 35:23–29CrossRefPubMed
69.
Aziz A, Menias CO, Sanchez LA, Picus D, Saad N, Rubin BG, Curci JA, Geraghty PJ (2012) Outcomes of percutaneous endovascular intervention for type II endoleak with aneurysm expansion. J Vasc Surg 55:1263–1267CrossRefPubMed
70.
Stavropoulos SW, Park J, Fairman R, Carpenter J (2009) Type 2 endoleak embolization comparison: translumbar embolization versus modified transarterial embolization. J Vasc Interv Radiology 20(10):1299–1302CrossRef
71.
Mansueto G, Cenzi D, Scuro A, Gottin L, Griso A, Gumbs AA, Mucelli RP (2007) Treatment of type II endoleak with a transcatheter transcaval approach: results at 1-year follow-up. J Vasc Surg 45:1120–1127CrossRefPubMed
72.
Midulla M, Perini P, Sundareyan R, Lazguet Y, Dehaene A, Goyault G, Martinelli T, Haulon S (2012) Transcatheter transcaval embolization of a type II endoleak after EVAR using a transseptal needle-sheath system. Vasc Endovasc. Surg. 46(5):410–413CrossRef
73.
Wisselink W, Cuesta MA, Berenda FJ, van den Berg FG, Rauwerda JA (2000) Retroperitoneal endoscopic ligation of lumbar and inferior mesenteric arteries as a treatment of persistent endoleak after endoluminal aortic aneurysm repair. J Vasc Surg 31:1240–1244CrossRefPubMed
74.
Richardson WS, Sternbergh WC 3rd, Money SR (2003) Laparoscopic inferior mesenteric artery ligation: an alternative for the treatment of type II endoleaks. J Laparoendosc Adv Surg Tech A 13(6):355–358CrossRefPubMed
75.
Ho P, Law WL, Tung PH, Poon JT, Ting AC, Cheng SW (2004) Laparoscopic transperitoneal clipping of the inferior mesenteric artery for the management of type II endoleak after endovascular repair of an aneurysm. Surg Endosc 18:870PubMed
76.
Kolvenbach R, Pinter L, Raghunandan M et al (2002) Laparoscopic remodelling of abdominal aortic aneurysms after endovascular exclusion: a technical description. J Vasc Surg 36:1267–1270CrossRefPubMed
77.
Lin JC, Eun D, Shrivastava A, Shepard AD, Reddy DJ (2009) Total robotic ligation of inferior mesenteric artery for type II endoleak after endovascular aneurysm repair. Ann Vasc Surg 23(2):255.e19–255.e21CrossRef
78.
Linsen MA, Daniles L, Cuesta MA, Wisselink W (2011) Endoscopic type 2 endoleak repair following endovascular aortic aneurysm repair: acute results and follow-up experience. Vascular 19(3):121–125CrossRefPubMed
79.
Halak M, McDonnell CO, Muhlmann MD, Baker SR (2007) Open surgical treatment of aneurysmal sac expansion following endovascular abdominal aneurysm repair: solution for an unresolved clinical dilemma. Vascular 15(4):201–204CrossRefPubMed
Metadata
Title
Type 2 Endoleaks Post-EVAR: Current Evidence for Rupture Risk, Intervention and Outcomes of Treatment
Authors
Raymond Chung
Robert A. Morgan
Publication date
01-06-2015
Publisher
Springer US
Published in
CardioVascular and Interventional Radiology / Issue 3/2015
Print ISSN: 0174-1551
Electronic ISSN: 1432-086X
DOI
https://doi.org/10.1007/s00270-014-0987-x

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