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CardioVascular and Interventional Radiology

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01-04-2015 | Laboratory Investigation

Temporary Arterial Embolization of Liver Parenchyma with Degradable Starch Microspheres (EmboCept^®S) in a Swine Model

Authors: Claus C. Pieper, Carsten Meyer, Brigitte Vollmar, Karlheinz Hauenstein, Hans H. Schild, Kai E. Wilhelm

Published in: CardioVascular and Interventional Radiology | Issue 2/2015

Abstract

Background

This study aimed to evaluate the embolic properties, time to reperfusion, and histologic changes in temporary embolization of liver tissue with degradable starch microspheres (DSM) in a swine model.

Methods

In four adult minipigs, DSMs were injected into the right or left hepatic artery on the lobar level until complete stasis of the blood flow was detectable angiographically. The time required to complete angiographically determined reperfusion was noted. The animals were killed 3 h after complete reperfusion, and samples were taken from the liver. Histologic examinations of the embolized liver parenchyma and untreated tissue were performed.

Results

Hepatic arterial embolization using DSMs was technically successful in all cases, with complete blood flow stasis shown by control angiography. A single vial of DSMs (450 mg/7.5 ml) was sufficient to embolize a whole liver lobe in all cases. Angiography showed complete reconstitution of hepatic arterial perfusion after a mean time to reperfusion of 32 ± 6.1 min (range, 26–39 min). Hematoxylin and eosin staining showed no histologically detectable differences between untreated tissue and parenchyma embolized with DSMs except for mild sinusoidal congestion in one case. Indirect in situ DNA nick end labeling staining (TUNEL) showed only single positive hepatocytes, indicating apoptosis.

Conclusion

Temporary embolization of the hepatic artery using DSMs is feasible with complete reperfusion after 30 min in pigs. Even after complete arterial blood flow stasis, no extensive tissue damage to the embolized liver parenchyma was observed at histologic examinations in this short-term study.

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Title: Temporary Arterial Embolization of Liver Parenchyma with Degradable Starch Microspheres (EmboCept®S) in a Swine Model
Authors: Claus C. Pieper
Carsten Meyer
Brigitte Vollmar
Karlheinz Hauenstein
Hans H. Schild
Kai E. Wilhelm
Publication date: 01-04-2015
Publisher: Springer US
Published in: CardioVascular and Interventional Radiology / Issue 2/2015
Print ISSN: 0174-1551
Electronic ISSN: 1432-086X
DOI: https://doi.org/10.1007/s00270-014-0966-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Temporary Arterial Embolization of Liver Parenchyma with Degradable Starch Microspheres (EmboCept^®S) in a Swine Model

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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