Skip to main content
Top
Published in: CardioVascular and Interventional Radiology 2/2014

01-04-2014 | Technical Note

Percutaneous Computer Tomography-Guided Ethanol Sympathicolysis for the Treatment of Resistant Arterial Hypertension

Authors: F. Streitparth, B. Gebauer, P. Nickel, P. Reinke, P. Freyhardt, G. Wieners, B. Hamm, R. W. Günther

Published in: CardioVascular and Interventional Radiology | Issue 2/2014

Login to get access

Abstract

Purpose

As an alternative to catheter-based radiofrequency (RF) ablation, renal sympathicolysis can also be achieved by image-guided percutaneous injection of ethanol around the renal artery.

Materials and Methods

We report the case of a 50-year-old man with refractory hypertension and end-stage renal failure of unclear etiology who was treated with computed tomography-guided percutaneous periarterial ethanol sympathicolysis.

Results

The procedure was painless. The patient’s BP decreased within 6 days from a baseline value of 172/84 mm Hg (1 week before treatment) to a sustained decreased value of 143/70 mm Hg 1 month after intervention, i.e., a decrease by 29/14 mm Hg. The patient’s hypertension-related headache resolved.

Conclusion

Image-guided periarterial ethanol injection for renal sympathetic denervation in a patient with drug-resistant hypertension is feasible. We provide a detailed description of this new interventional procedure and discuss its potential advantages compared with catheter-based RF ablation.
Literature
1.
go back to reference Wolf-Maier K, Cooper RS, Kramer H et al (2004) Hypertension treatment and control in five European countries, Canada, and the United States. Hypertension 43(1):10–17PubMedCrossRef Wolf-Maier K, Cooper RS, Kramer H et al (2004) Hypertension treatment and control in five European countries, Canada, and the United States. Hypertension 43(1):10–17PubMedCrossRef
2.
go back to reference Lloyd-Jones D, Adams RJ, Brown TM et al (2010) Heart disease and stroke statistics—2010 update: a report from the American Heart Association. Circulation 121(7):e46–e215PubMedCrossRef Lloyd-Jones D, Adams RJ, Brown TM et al (2010) Heart disease and stroke statistics—2010 update: a report from the American Heart Association. Circulation 121(7):e46–e215PubMedCrossRef
3.
go back to reference Esler M, Jennings G, Korner P et al (1988) Assessment of human sympathetic nervous system activity from measurements of norepinephrine turnover. Hypertension 11(1):3–20PubMedCrossRef Esler M, Jennings G, Korner P et al (1988) Assessment of human sympathetic nervous system activity from measurements of norepinephrine turnover. Hypertension 11(1):3–20PubMedCrossRef
4.
go back to reference Schlaich MP, Lambert E, Kaye DM et al (2004) Sympathetic augmentation in hypertension: role of nerve firing, norepinephrine reuptake, and angiotensin neuromodulation. Hypertension 43(2):169–175PubMedCrossRef Schlaich MP, Lambert E, Kaye DM et al (2004) Sympathetic augmentation in hypertension: role of nerve firing, norepinephrine reuptake, and angiotensin neuromodulation. Hypertension 43(2):169–175PubMedCrossRef
5.
go back to reference Krum H, Schlaich M, Whitbourn R et al (2009) Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study. Lancet 373(9671):1275–1281PubMedCrossRef Krum H, Schlaich M, Whitbourn R et al (2009) Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study. Lancet 373(9671):1275–1281PubMedCrossRef
6.
go back to reference Esler MD, Krum H, Sobotka PA, Schlaich MP, Schmieder RE, Bohm M (2010) Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. Lancet 376(9756):1903–1909PubMedCrossRef Esler MD, Krum H, Sobotka PA, Schlaich MP, Schmieder RE, Bohm M (2010) Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. Lancet 376(9756):1903–1909PubMedCrossRef
7.
go back to reference Investigators SH (2011) Catheter-based renal sympathetic denervation for resistant hypertension: durability of blood pressure reduction out to 24 months. Hypertension 57(5):911–917CrossRef Investigators SH (2011) Catheter-based renal sympathetic denervation for resistant hypertension: durability of blood pressure reduction out to 24 months. Hypertension 57(5):911–917CrossRef
8.
go back to reference Esler MD, Krum H, Schlaich M, Schmieder RE, Bohm M, Sobotka PA (2012) Renal sympathetic denervation for treatment of drug-resistant hypertension: one-year results from the Symplicity HTN-2 randomized, controlled trial. Circulation 126(25):2976–2982PubMedCrossRef Esler MD, Krum H, Schlaich M, Schmieder RE, Bohm M, Sobotka PA (2012) Renal sympathetic denervation for treatment of drug-resistant hypertension: one-year results from the Symplicity HTN-2 randomized, controlled trial. Circulation 126(25):2976–2982PubMedCrossRef
9.
go back to reference Kandzari DE, Bhatt DL, Sobotka PA et al (2012) Catheter-based renal denervation for resistant hypertension: rationale and design of the SYMPLICITY HTN-3 trial. Clin Cardiol 35(9):528–535PubMedCrossRef Kandzari DE, Bhatt DL, Sobotka PA et al (2012) Catheter-based renal denervation for resistant hypertension: rationale and design of the SYMPLICITY HTN-3 trial. Clin Cardiol 35(9):528–535PubMedCrossRef
10.
go back to reference Krum H, Sobotka P, Mahfoud F, Bohm M, Esler M, Schlaich M (2011) Device-based antihypertensive therapy: therapeutic modulation of the autonomic nervous system. Circulation 123(2):209–215PubMedCrossRef Krum H, Sobotka P, Mahfoud F, Bohm M, Esler M, Schlaich M (2011) Device-based antihypertensive therapy: therapeutic modulation of the autonomic nervous system. Circulation 123(2):209–215PubMedCrossRef
11.
go back to reference Lambert GW, Hering D, Esler MD et al (2012) Health-related quality of life after renal denervation in patients with treatment-resistant hypertension. Hypertension 60(6):1479–1484PubMedCrossRef Lambert GW, Hering D, Esler MD et al (2012) Health-related quality of life after renal denervation in patients with treatment-resistant hypertension. Hypertension 60(6):1479–1484PubMedCrossRef
12.
go back to reference Mahfoud F, Cremers B, Janker J et al (2012) Renal hemodynamics and renal function after catheter-based renal sympathetic denervation in patients with resistant hypertension. Hypertension 60(2):419–424PubMedCrossRef Mahfoud F, Cremers B, Janker J et al (2012) Renal hemodynamics and renal function after catheter-based renal sympathetic denervation in patients with resistant hypertension. Hypertension 60(2):419–424PubMedCrossRef
13.
go back to reference Ormiston JA, Watson T, van Pelt N et al (2013) First-in-human use of the OneShot renal denervation system from Covidien. EuroIntervention 8(9):1090–1094PubMedCrossRef Ormiston JA, Watson T, van Pelt N et al (2013) First-in-human use of the OneShot renal denervation system from Covidien. EuroIntervention 8(9):1090–1094PubMedCrossRef
14.
go back to reference Schlaich MP, Hering D, Sobotka PA, Krum H, Esler MD (2012) Renal denervation in human hypertension: mechanisms, current findings, and future prospects. Curr Hypertens Rep 14(3):247–253PubMedCrossRef Schlaich MP, Hering D, Sobotka PA, Krum H, Esler MD (2012) Renal denervation in human hypertension: mechanisms, current findings, and future prospects. Curr Hypertens Rep 14(3):247–253PubMedCrossRef
15.
go back to reference Mabin T, Sapoval M, Cabane V, Stemmett J, Iyer M (2012) First experience with endovascular ultrasound renal denervation for the treatment of resistant hypertension. EuroIntervention 8(1):57–61PubMedCrossRef Mabin T, Sapoval M, Cabane V, Stemmett J, Iyer M (2012) First experience with endovascular ultrasound renal denervation for the treatment of resistant hypertension. EuroIntervention 8(1):57–61PubMedCrossRef
16.
go back to reference Rippy MK, Zarins D, Barman NC, Wu A, Duncan KL, Zarins CK (2011) Catheter-based renal sympathetic denervation: chronic preclinical evidence for renal artery safety. Clin Res Cardiol 100(12):1095–1101PubMedCrossRef Rippy MK, Zarins D, Barman NC, Wu A, Duncan KL, Zarins CK (2011) Catheter-based renal sympathetic denervation: chronic preclinical evidence for renal artery safety. Clin Res Cardiol 100(12):1095–1101PubMedCrossRef
17.
go back to reference Cook S, Goy JJ, Togni M (2012) Optical coherence tomography findings in renal denervation. Eur Heart J 33(23):2992PubMedCrossRef Cook S, Goy JJ, Togni M (2012) Optical coherence tomography findings in renal denervation. Eur Heart J 33(23):2992PubMedCrossRef
18.
go back to reference Kaltenbach B, Id D, Franke JC et al (2012) Renal artery stenosis after renal sympathetic denervation. J Am Coll Cardiol 60(25):2694–2695PubMedCrossRef Kaltenbach B, Id D, Franke JC et al (2012) Renal artery stenosis after renal sympathetic denervation. J Am Coll Cardiol 60(25):2694–2695PubMedCrossRef
19.
go back to reference Vonend O, Antoch G, Rump LC, Blondin D (2012) Secondary rise in blood pressure after renal denervation. Lancet 380(9843):778PubMedCrossRef Vonend O, Antoch G, Rump LC, Blondin D (2012) Secondary rise in blood pressure after renal denervation. Lancet 380(9843):778PubMedCrossRef
20.
go back to reference Streitparth F, Walter A, Stolzenburg N et al (2013) MR-guided periarterial ethanol injection for renal sympathetic denervation: a feasibility study in pigs. Cardiovasc Intervent Radiol 36(3):791–796PubMedCrossRef Streitparth F, Walter A, Stolzenburg N et al (2013) MR-guided periarterial ethanol injection for renal sympathetic denervation: a feasibility study in pigs. Cardiovasc Intervent Radiol 36(3):791–796PubMedCrossRef
21.
go back to reference Fischell TA, Vega F, Raju N et al (2013) Ethanol-mediated perivascular renal sympathetic denervation: preclinical validation of safety and efficacy in a porcine model. EuroIntervention 9(1):140–147PubMedCrossRef Fischell TA, Vega F, Raju N et al (2013) Ethanol-mediated perivascular renal sympathetic denervation: preclinical validation of safety and efficacy in a porcine model. EuroIntervention 9(1):140–147PubMedCrossRef
22.
go back to reference Schlaich MP, Sobotka PA, Krum H, Lambert E, Esler MD (2009) Renal sympathetic-nerve ablation for uncontrolled hypertension. N Engl J Med 361(9):932–934PubMedCrossRef Schlaich MP, Sobotka PA, Krum H, Lambert E, Esler MD (2009) Renal sympathetic-nerve ablation for uncontrolled hypertension. N Engl J Med 361(9):932–934PubMedCrossRef
23.
go back to reference Kocabas H, Salli A, Demir AH, Ozerbil OM (2010) Comparison of phenol and alcohol neurolysis of tibial nerve motor branches to the gastrocnemius muscle for treatment of spastic foot after stroke: a randomized controlled pilot study. Eur J Phys Rehabil Med 46(1):5–10PubMed Kocabas H, Salli A, Demir AH, Ozerbil OM (2010) Comparison of phenol and alcohol neurolysis of tibial nerve motor branches to the gastrocnemius muscle for treatment of spastic foot after stroke: a randomized controlled pilot study. Eur J Phys Rehabil Med 46(1):5–10PubMed
24.
go back to reference Moller JE, Helweg-Larsen J, Jacobsen E (1969) Histopathological lesions in the sciatic nerve of the rat following perineural application of phenol and alcohol solutions. Dan Med Bull 16(4):116–119PubMed Moller JE, Helweg-Larsen J, Jacobsen E (1969) Histopathological lesions in the sciatic nerve of the rat following perineural application of phenol and alcohol solutions. Dan Med Bull 16(4):116–119PubMed
25.
go back to reference Wilkes D, Ganceres N, Doulatram G, Solanki D (2009) Alcohol neurolysis of the sciatic and femoral nerves to improve pressure ulcer healing. Pain Pract 9(2):145–149PubMedCrossRef Wilkes D, Ganceres N, Doulatram G, Solanki D (2009) Alcohol neurolysis of the sciatic and femoral nerves to improve pressure ulcer healing. Pain Pract 9(2):145–149PubMedCrossRef
26.
go back to reference Atherton DS, Deep NL, Mendelsohn FO (2012) Micro-anatomy of the renal sympathetic nervous system: a human postmortem histologic study. Clin Anat 25(5):628–633PubMedCrossRef Atherton DS, Deep NL, Mendelsohn FO (2012) Micro-anatomy of the renal sympathetic nervous system: a human postmortem histologic study. Clin Anat 25(5):628–633PubMedCrossRef
27.
go back to reference Stefanadis C, Toutouzas K, Synetos A et al (2013) Chemical denervation of the renal artery by vincristine in swine. A new catheter based technique. Int J Cardiol 167(2):421–425PubMedCrossRef Stefanadis C, Toutouzas K, Synetos A et al (2013) Chemical denervation of the renal artery by vincristine in swine. A new catheter based technique. Int J Cardiol 167(2):421–425PubMedCrossRef
28.
go back to reference Esler M, Schlaich M, Sobotka P et al (2009) Catheter-based renal denervation reduces total body and renal noradrenaline spillover and blood pressure in resistant hypertension. J Hypertens 27(Suppl 4):s167 Esler M, Schlaich M, Sobotka P et al (2009) Catheter-based renal denervation reduces total body and renal noradrenaline spillover and blood pressure in resistant hypertension. J Hypertens 27(Suppl 4):s167
Metadata
Title
Percutaneous Computer Tomography-Guided Ethanol Sympathicolysis for the Treatment of Resistant Arterial Hypertension
Authors
F. Streitparth
B. Gebauer
P. Nickel
P. Reinke
P. Freyhardt
G. Wieners
B. Hamm
R. W. Günther
Publication date
01-04-2014
Publisher
Springer US
Published in
CardioVascular and Interventional Radiology / Issue 2/2014
Print ISSN: 0174-1551
Electronic ISSN: 1432-086X
DOI
https://doi.org/10.1007/s00270-014-0850-0

Other articles of this Issue 2/2014

CardioVascular and Interventional Radiology 2/2014 Go to the issue