Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
CardioVascular and Interventional Radiology
Published in: CardioVascular and Interventional Radiology 2/2012

01-04-2012 | Laboratory Investigation

Angiography in the Isolated Perfused Kidney: Radiological Evaluation of Vascular Protection in Tissue Ablation by Nonthermal Irreversible Electroporation

Authors: Johann Jakob Wendler, Maciej Pech, Simon Blaschke, Markus Porsch, Andreas Janitzky, Matthias Ulrich, Oliver Dudeck, Jens Ricke, Uwe-Bernd Liehr

Published in: CardioVascular and Interventional Radiology | Issue 2/2012

Login to get access

Abstract

Purpose

The nonthermal irreversible electroporation (NTIRE) is a novel nonthermal tissue ablation technique by local application of high-voltage current within microseconds leading to a delayed apoptosis. The purpose of this experimental study was the first angiographic evaluation of the acute damage of renal vascular structure in NTIRE.

Methods

Results of conventional dynamic digital substraction angiography (DSA) and visualization of the terminal vascular bed of renal parenchyma by high-resolution X-ray in mammography technique were evaluated before, during, and after NTIRE of three isolated perfused porcine ex vivo kidneys.

Results

In the dedicated investigation, no acute vascular destruction of the renal parenchyma and no dysfunction of the kidney perfusion model were observed during or after NTIRE. Conspicuous were concentric wave-like fluctuations of the DSA contrast agent simultaneous to the NTIRE pulses resulting from NTIRE pulse shock wave.

Conclusion

The NTIRE offers an ablation method with no acute collateral vascular damage in angiographic evaluation.
Literature
1.
Rubinsky B, Onik G, Mikus P (2007) Irreversible electroporation: a new ablation modality—clinical implications. Technol Cancer Res Treat 6(1):37–48PubMed
2.
3.
Onik G, Mikus P, Rubinsky B (2007) Irreversible electroporation: implications for prostate ablation. Technol Cancer Res Treat 6(4):295–300PubMed
4.
Dupuy DE, Aswad B, Ng T (2011) Irreversible electroporation in a swine lung model. Cardiovasc Intervent Radiol 34:391–395PubMedCrossRef
5.
Sano MB, Neal RE 2nd, Garcia PA, Gerber D, Robertson J, Davalos RV (2010) Towards the creation of decellularized organ constructs using irreversible electroporation and active mechanical perfusion. Biomed Eng Online 9(1):83PubMedCrossRef
6.
Deodhar A, Monette S, Single GW Jr, Hamilton WC Jr, Thornton R, Maybody M, Coleman JA, Solomon SB (2011) Renal tissue ablation with irreversible electroporation: preliminary results in a porcine model. Urology 77:754–760PubMedCrossRef
7.
Garcia PA, Neal RE, Rossmeisl JH, Davalos RV (2010) Non-thermal irreversible electroporation for deep intracranial disorders. Conf Proc IEEE Eng Med Biol Soc 1:2743–2746
8.
Charpentier KP, Wolf F, Noble L, Winn B, Resnick M, Dupuy DE (2010) Irreversible electroporation of the pancreas in swine: a pilot study. HPB (Oxford) 12(5):348–351
9.
Maor E, Ivorra A, Mitchell JJ, Rubinsky B (2010) Vascular smooth muscle cells ablation with endovascular nonthermal irreversible electroporation. J Vasc Interv Radiol 21(11):1708–1715PubMedCrossRef
10.
Al-Sakere B, André F, Bernat C, Connault E, Opolon P, Davalos RV, Rubinsky B, Mir LM (2007) Tumor ablation with irreversible electroporation. PLoS One 2(11):e1135PubMedCrossRef
11.
Lee EW, Chen C, Prieto VE, Dry SM, Loh CT, Kee ST (2010) Advanced hepatic ablation technique for creating complete cell death: irreversible electroporation. Radiology 255(2):426–433PubMedCrossRef
12.
Hong J, Stewart MT, Cheek DS, Francischelli DE, Kirchhof N (2009) Cardiac ablation via electroporation. Conf Proc IEEE Eng Med Biol Soc 2009:3381–3384PubMed
13.
Lee EW, Thai S, Kee ST (2010) Irreversible electroporation: a novel image-guided cancer therapy. Gut Liver 4(Suppl 1):S99–S104PubMedCrossRef
14.
Goldberg SN, Charboneau JW, Dodd GD 3rd, Dupuy DE, Gervais DA, Gillams AR, Kane RA, Lee FT Jr, Livraghi T, McGahan JP, Rhim H, Silverman SG, Solbiati L, Vogl TJ, Wood BJ, International Working Group on Image-Guided Tumor Ablation (2003) Image-guided tumor ablation: proposal for standardization of terms and reporting criteria. Radiology 228(2):335–345PubMedCrossRef
15.
Granot Y, Ivorra A, Maor E, Rubinsky B (2009) In vivo imaging of irreversible electroporation by means of electrical impedance tomography. Phys Med Biol 54(16):4927–4943PubMedCrossRef
16.
Lee EW, Loh CT, Kee ST (2007) Imaging guided percutaneous irreversible electroporation: ultrasound and immunohistological correlation. Technol Cancer Res Treat 6(4):287–294PubMed
17.
Thomson KR, Cheung W, Ellis SJ, Park D, Kavnoudias H, Loader-Oliver D, Roberts S, Evans P, Ball C, Haydon A (2011) Investigation of the safety of irreversible electroporation in humans. J Vasc Interv Radiol 22(5):611–621PubMedCrossRef
18.
Pech M, Janitzky A, Wendler JJ, Strang C, Blaschke S, Dudeck O, Ricke J, Liehr UB (2011) Irreversible electroporation of renal cell carcinoma: a first-in-man phase I clinical study. Cardiovasc Intervent Radiol 34:132–138PubMedCrossRef
19.
Ball C, Thomson KR, Kavnoudias H (2010) Irreversible electroporation: a new challenge in “out of operating theater” anesthesia. Anesth Analg 110(5):1305–1309PubMedCrossRef
20.
Ljungberg B, Cowan N, Hanbury DC, Hora M, Kuczyk MA, Merseburger AS, Mulders PFA, Patard JJ, Sinescu IC (2010) Guidelines on Renal Cell Carcinoma. European Association of Urology (EAU). http://​www.​uroweb.​org/​. Accessed 25 May 2011
21.
Maor E, Ivorra A, Leor J, Rubinsky B (2007) The effect of irreversible electroporation on blood vessels. Technol Cancer Res Treat 6(4):307–312PubMed
22.
Häcker A, Chauhan S, Peters K, Hildenbrand R, Marlinghaus E, Alken P, Michel MS (2005) Multiple high-intensity focused ultrasound probes for kidney-tissue ablation. J Endourol 19(8):1036–1040PubMedCrossRef
23.
Köhrmann KU, Back W, Bensemann J, Florian J, Weber A, Kahmann F, Rassweiler J, Alken P (1994) The isolated perfused kidney of the pig: new model to evaluate shock wave-induced lesions. J Endourol 8(2):105–110PubMedCrossRef
24.
25.
Duffey BG, Kyle Anderson J (2010) Current and future technology for minimally invasive ablation of renal cell carcinoma. Indian J Urol 26(3):410–417PubMedCrossRef
26.
Sersa G, Jarm T, Kotnik T, Coer A, Podkrajsek M, Sentjurc M, Miklavcic D, Kadivec M, Kranjc S, Secerov A, Cemazar M (2008) Vascular disrupting action of electroporation and electrochemotherapy with bleomycin in murine sarcoma. Br J Cancer 98(2):388–398PubMedCrossRef
Metadata
Title
Angiography in the Isolated Perfused Kidney: Radiological Evaluation of Vascular Protection in Tissue Ablation by Nonthermal Irreversible Electroporation
Authors
Johann Jakob Wendler
Maciej Pech
Simon Blaschke
Markus Porsch
Andreas Janitzky
Matthias Ulrich
Oliver Dudeck
Jens Ricke
Uwe-Bernd Liehr
Publication date
01-04-2012
Publisher
Springer-Verlag
Published in
CardioVascular and Interventional Radiology / Issue 2/2012
Print ISSN: 0174-1551
Electronic ISSN: 1432-086X
DOI
https://doi.org/10.1007/s00270-011-0187-x

Other articles of this Issue 2/2012

CardioVascular and Interventional Radiology 2/2012 Go to the issue

Case Report

Treatment of a Traumatic Celiac Trunk Detachment by Bridging with a Stent Graft

Letter to the Editor

Percutaneous Retrieval of an Amplatzer Septal Occluder Device that had migrated to the Aortic Arch

Obituary

In Memoriam

Letter to the Editor

Splenic Venous Congestion after Balloon-Occluded Retrograde Transvenous Obliteration of Gastric Varices

Clinical Investigation

Percutaneous Decompression of Lumbar Spinal Stenosis with a New Interspinous Device

Laboratory Investigation

Optimization of Doxorubicin Loading for Superabsorbent Polymer Microspheres: in vitro Analysis