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Published in: CardioVascular and Interventional Radiology 5/2011

01-10-2011 | Review

Venous Thoracic Outlet Compression and the Paget-Schroetter Syndrome: A Review and Recommendations for Management

Authors: J. F. Thompson, R. J. Winterborn, S. Bays, H. White, D. C. Kinsella, A. F. Watkinson

Published in: CardioVascular and Interventional Radiology | Issue 5/2011

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Abstract

Paget Schroetter syndrome, or effort thrombosis of the axillosubclavian venous system, is distinct from other forms of upper limb deep vein thrombosis. It occurs in younger patients and often is secondary to competitive sport, music, or strenuous occupation. If untreated, there is a higher incidence of disabling venous hypertension than was previously appreciated. Anticoagulation alone or in combination with thrombolysis leads to a high rate of rethrombosis. We have established a multidisciplinary protocol over 15 years, based on careful patient selection and a combination of lysis, decompressive surgery, and postoperative percutaneous venoplasty. During the past 10 years, a total of 232 decompression procedures have been performed. This article reviews the literature and presents the Exeter Protocol along with practical recommendations for management.
Literature
1.
go back to reference Spencer FA, Emery C, Lessard D, Goldberg RJ (2008) Upper extremity deep vein thrombosis: a community-based perspective. J Vasc Surg 47(1):240–241CrossRef Spencer FA, Emery C, Lessard D, Goldberg RJ (2008) Upper extremity deep vein thrombosis: a community-based perspective. J Vasc Surg 47(1):240–241CrossRef
2.
go back to reference Elman EE, Kahn SR (2006) The post-thrombotic syndrome after upper extremity deep venous thrombosis in adults: a systematic review. Thromb Res 117(6):609–614PubMedCrossRef Elman EE, Kahn SR (2006) The post-thrombotic syndrome after upper extremity deep venous thrombosis in adults: a systematic review. Thromb Res 117(6):609–614PubMedCrossRef
3.
go back to reference Donayre CE, White GH, Mehringer SM, Wilson SE (1986) Pathogenesis determines late morbidity of axillosubclavian vein thrombosis. Am J Surg 152(2):179–184PubMedCrossRef Donayre CE, White GH, Mehringer SM, Wilson SE (1986) Pathogenesis determines late morbidity of axillosubclavian vein thrombosis. Am J Surg 152(2):179–184PubMedCrossRef
4.
go back to reference Kahn SR, Elman EA, Bornais C, Blostein M, Wells PS (2005) Post-thrombotic syndrome, functional disability and quality of life after upper extremity deep venous thrombosis in adults. Thromb Haemost 93(3):499–502PubMed Kahn SR, Elman EA, Bornais C, Blostein M, Wells PS (2005) Post-thrombotic syndrome, functional disability and quality of life after upper extremity deep venous thrombosis in adults. Thromb Haemost 93(3):499–502PubMed
5.
go back to reference Persson LM, Arnhjort T, Lärfars G, Rosfors S (2006) Hemodynamic and morphologic evaluation of sequelae of primary upper extremity deep venous thromboses treated with anticoagulation. J Vasc Surg 43(6):1230–1235PubMedCrossRef Persson LM, Arnhjort T, Lärfars G, Rosfors S (2006) Hemodynamic and morphologic evaluation of sequelae of primary upper extremity deep venous thromboses treated with anticoagulation. J Vasc Surg 43(6):1230–1235PubMedCrossRef
6.
go back to reference Bliss S, Weinberger S, Meier M, Saint S (2002) The unusual suspect. N Engl J Med 347(23):1876–1881PubMedCrossRef Bliss S, Weinberger S, Meier M, Saint S (2002) The unusual suspect. N Engl J Med 347(23):1876–1881PubMedCrossRef
7.
go back to reference Buller HR, Agnelli G, Hull RD, Hyers TM, Prins MH, Raskob GE (2004) Antithrombotic therapy for venous thromboembolic disease: the seventh ACCP conference on antithrombotic and thrombolytic therapy. Chest 126:401S–428SPubMedCrossRef Buller HR, Agnelli G, Hull RD, Hyers TM, Prins MH, Raskob GE (2004) Antithrombotic therapy for venous thromboembolic disease: the seventh ACCP conference on antithrombotic and thrombolytic therapy. Chest 126:401S–428SPubMedCrossRef
8.
go back to reference Sajid MS, Ahmed N, Desai M, Baker D, Hamilton G (2007) Upper limb deep vein thrombosis: a literature review to streamline the protocol for management. Acta Haematol 118:10–18PubMedCrossRef Sajid MS, Ahmed N, Desai M, Baker D, Hamilton G (2007) Upper limb deep vein thrombosis: a literature review to streamline the protocol for management. Acta Haematol 118:10–18PubMedCrossRef
9.
go back to reference Lee JT, Karwowski JK, Harris EJ, Haukoos JS, Olcott C (2006) Long-term thrombotic recurrence after nonoperative management of Paget-Schroetter syndrome. J Vasc Surg 43(6):1236–1243PubMedCrossRef Lee JT, Karwowski JK, Harris EJ, Haukoos JS, Olcott C (2006) Long-term thrombotic recurrence after nonoperative management of Paget-Schroetter syndrome. J Vasc Surg 43(6):1236–1243PubMedCrossRef
10.
go back to reference Urschel HC, Patel AN (2003) Paget-Schroetter syndrome therapy: failure of intravenous stents. Ann Thorac Surg 75(6):1693–1696 discussion 1696PubMedCrossRef Urschel HC, Patel AN (2003) Paget-Schroetter syndrome therapy: failure of intravenous stents. Ann Thorac Surg 75(6):1693–1696 discussion 1696PubMedCrossRef
11.
go back to reference Urschel HC, Patel AN (2008) Surgery remains the most effective treatment for Paget-Schroetter syndrome: 50 years’ experience. Ann Thorac Surg 86(1):254–260 discussion 260PubMedCrossRef Urschel HC, Patel AN (2008) Surgery remains the most effective treatment for Paget-Schroetter syndrome: 50 years’ experience. Ann Thorac Surg 86(1):254–260 discussion 260PubMedCrossRef
12.
go back to reference Machleder HI (1993) Evaluation of a new treatment strategy for Paget-Schroetter syndrome: spontaneous thrombosis of the axillary-subclavian vein. J Vasc Surg 17(2):305–317PubMedCrossRef Machleder HI (1993) Evaluation of a new treatment strategy for Paget-Schroetter syndrome: spontaneous thrombosis of the axillary-subclavian vein. J Vasc Surg 17(2):305–317PubMedCrossRef
13.
go back to reference Molina JE, Hunter DW, Dietz CA (2007) Paget-Schroetter syndrome treated with thrombolytics and immediate surgery. J Vasc Surg 45(2):328–334PubMedCrossRef Molina JE, Hunter DW, Dietz CA (2007) Paget-Schroetter syndrome treated with thrombolytics and immediate surgery. J Vasc Surg 45(2):328–334PubMedCrossRef
14.
go back to reference Melby SJ, Vedantham S, Narra VR, Paletta GA, Khoo-Summers L, Driskill M et al (2008) Comprehensive surgical management of the competitive athlete with effort thrombosis of the subclavian vein (Paget-Schroetter syndrome). J Vasc Surg 47:809–820PubMedCrossRef Melby SJ, Vedantham S, Narra VR, Paletta GA, Khoo-Summers L, Driskill M et al (2008) Comprehensive surgical management of the competitive athlete with effort thrombosis of the subclavian vein (Paget-Schroetter syndrome). J Vasc Surg 47:809–820PubMedCrossRef
15.
go back to reference Schneider DM, Dimuzio PJ, Martin LD, Gordon RL, Wilson MW, Laberge JM et al (2004) Combination treatment of venous thoracic outlet syndrome: open surgical decompression and intraoperative angioplasty. J Vasc Surg 40:599–603PubMedCrossRef Schneider DM, Dimuzio PJ, Martin LD, Gordon RL, Wilson MW, Laberge JM et al (2004) Combination treatment of venous thoracic outlet syndrome: open surgical decompression and intraoperative angioplasty. J Vasc Surg 40:599–603PubMedCrossRef
16.
go back to reference de León RA, Chang DC, Hassoun HT, Black JH, Roseborough GS, Perler BA et al (2009) Multiple treatment algorithms for successful outcomes in venous thoracic outlet syndrome. Surgery 145(5):500–507PubMedCrossRef de León RA, Chang DC, Hassoun HT, Black JH, Roseborough GS, Perler BA et al (2009) Multiple treatment algorithms for successful outcomes in venous thoracic outlet syndrome. Surgery 145(5):500–507PubMedCrossRef
17.
go back to reference Caparrelli DJ, Freischlag J (2008) A unified approach to axillosubclavian venous thrombosis in a single hospital admission. Semin Vasc Surg 18(3):153–157CrossRef Caparrelli DJ, Freischlag J (2008) A unified approach to axillosubclavian venous thrombosis in a single hospital admission. Semin Vasc Surg 18(3):153–157CrossRef
18.
go back to reference Doyle A, Wolford HY, Davies MG, Adams JT, Singh MJ, Saad WE et al (2007) Management of effort thrombosis of the subclavian vein: today’s treatment. Ann Vasc Surg 21(6):723–729PubMedCrossRef Doyle A, Wolford HY, Davies MG, Adams JT, Singh MJ, Saad WE et al (2007) Management of effort thrombosis of the subclavian vein: today’s treatment. Ann Vasc Surg 21(6):723–729PubMedCrossRef
19.
go back to reference Lee JT, Karwowski JK, Harris EJ, Haukoos JS, Olcott J (2006) Long-term thrombotic recurrence after nonoperative management of Paget-Schroetter syndrome. J Vasc Surg 43:1236–1243PubMedCrossRef Lee JT, Karwowski JK, Harris EJ, Haukoos JS, Olcott J (2006) Long-term thrombotic recurrence after nonoperative management of Paget-Schroetter syndrome. J Vasc Surg 43:1236–1243PubMedCrossRef
20.
go back to reference Lokanathan R, Salvian AJ, Chen JC, Morris C, Taylor DC, Hsiang YN (2001) Outcome after thrombolysis and selective thoracic outlet decompression for primary axillary vein thrombosis. J Vasc Surg 33(4):783–788PubMedCrossRef Lokanathan R, Salvian AJ, Chen JC, Morris C, Taylor DC, Hsiang YN (2001) Outcome after thrombolysis and selective thoracic outlet decompression for primary axillary vein thrombosis. J Vasc Surg 33(4):783–788PubMedCrossRef
21.
go back to reference Angle N, Gelabert HA, Farooq MM, Ahn SS, Caswell DR, Freischlag JA et al (2001) Safety and efficacy of early surgical decompression of the thoracic outlet for Paget-Schroetter syndrome. Ann Vasc Surg 15(1):37–42PubMedCrossRef Angle N, Gelabert HA, Farooq MM, Ahn SS, Caswell DR, Freischlag JA et al (2001) Safety and efficacy of early surgical decompression of the thoracic outlet for Paget-Schroetter syndrome. Ann Vasc Surg 15(1):37–42PubMedCrossRef
22.
go back to reference Thompson JF (2001) Transaxillary first rib resection. In: Greenhalgh RM (ed) Vascular and endovascular surgical techniques. WB Saunders, London, pp 279–282 Thompson JF (2001) Transaxillary first rib resection. In: Greenhalgh RM (ed) Vascular and endovascular surgical techniques. WB Saunders, London, pp 279–282
Metadata
Title
Venous Thoracic Outlet Compression and the Paget-Schroetter Syndrome: A Review and Recommendations for Management
Authors
J. F. Thompson
R. J. Winterborn
S. Bays
H. White
D. C. Kinsella
A. F. Watkinson
Publication date
01-10-2011
Publisher
Springer-Verlag
Published in
CardioVascular and Interventional Radiology / Issue 5/2011
Print ISSN: 0174-1551
Electronic ISSN: 1432-086X
DOI
https://doi.org/10.1007/s00270-011-0148-4

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