Skip to main content
Top
Published in: CardioVascular and Interventional Radiology 1/2007

01-02-2007 | TECHNICAL NOTE

Right Gastric Artery Embolization Prior to Treatment with Yttrium-90 Microspheres

Authors: Octavio Cosin, Jose Ignacio Bilbao, Sergio Alvarez, Esther de Luis, Alberto Alonso, Antonio Martinez-Cuesta

Published in: CardioVascular and Interventional Radiology | Issue 1/2007

Login to get access

Abstract

Purpose

Intra-arterial infusion of yttrium-90 microspheres is a form of radiation treatment for unresectable hepatic neoplasms. Misdeposition of particles in the gastroduodenal area such as the right gastric artery (RGA) may occur with serious consequences. We present a series of patients who underwent a detailed vascular study followed by RGA embolization. Special emphasis is placed on anatomic variations and technical considerations.

Methods

In a 1 year period, 27 patients were treated. Initial vascular evaluation was performed, with careful attention to anatomic variants or extrahepatic arterial supply, especially to the gastroduodenal area. Embolization of such arteries was planned if needed. RGA embolization was performed antegradely from the hepatic artery or retrogradely via the left gastric artery (LGA). Postprocedural follow-up included clinical interview and gastroscopy if necessary.

Results

RGA embolization was performed in 9 patients presenting with primary (n = 3) or metastatic liver tumors (n = 6). Six patients underwent antegrade RGA embolization and 3 had embolization done retrogradely via the LGA. Retrograde access was chosen for anatomic reasons. None of the patients complained of gastroduodenal symptoms.

Conclusion

RGA embolization can help minimize the gastroduodenal deposition of radioactive particles. RGA embolization should routinely be carried out. The procedure can be performed, with similar technical success, by both anterograde and retrograde approaches.
Literature
1.
go back to reference Dawson LA, Normolle D, Balter JM, McGinn CJ, Lawrence TS, Ten Haken RK (2002) Analysis of radiation-induced liver disease using the Lyman NTCP model. Int J Radiat Oncol Biol Phys 53:810–821PubMedCrossRef Dawson LA, Normolle D, Balter JM, McGinn CJ, Lawrence TS, Ten Haken RK (2002) Analysis of radiation-induced liver disease using the Lyman NTCP model. Int J Radiat Oncol Biol Phys 53:810–821PubMedCrossRef
2.
go back to reference Cohen AD, Kemeny NE (2003) An update on hepatic arterial infusion for colorectal cancer. Oncologist 8:553–566PubMedCrossRef Cohen AD, Kemeny NE (2003) An update on hepatic arterial infusion for colorectal cancer. Oncologist 8:553–566PubMedCrossRef
3.
go back to reference Shike M, Gillin JS, Kemeny N, Daly JM, Kurtz RC (1986) Severe gastroduodenal ulcerations complicating hepatic artery infusion chemotherapy for metastatic colon cancer. Am J Gastroenterol 81:176–179PubMed Shike M, Gillin JS, Kemeny N, Daly JM, Kurtz RC (1986) Severe gastroduodenal ulcerations complicating hepatic artery infusion chemotherapy for metastatic colon cancer. Am J Gastroenterol 81:176–179PubMed
4.
go back to reference Leung TK, Lee CM, Chen HC (2005) Anatomic and technical skill factor of gastroduodenal complication in post-transarterial embolization for hepatocellular carcinoma: a retrospective study of 280 cases. World J Gastroenterol 11:1554–1557PubMed Leung TK, Lee CM, Chen HC (2005) Anatomic and technical skill factor of gastroduodenal complication in post-transarterial embolization for hepatocellular carcinoma: a retrospective study of 280 cases. World J Gastroenterol 11:1554–1557PubMed
5.
go back to reference Campbell KA, Burns RC, Sitzmann JV, Lipsett PA, Grochow LB, Niederhuber JE (1993) Regional chemotherapy devices: effect of experience and anatomy on complications. J Clin Oncol 11:822–826PubMed Campbell KA, Burns RC, Sitzmann JV, Lipsett PA, Grochow LB, Niederhuber JE (1993) Regional chemotherapy devices: effect of experience and anatomy on complications. J Clin Oncol 11:822–826PubMed
6.
go back to reference Chuang VP, Wallace S, Stroehlein J, Yap HY, Patt YZ (1981) Hepatic artery infusion chemotherapy: Gastroduodenal complications. AJR Am J Roentgenol 137:347–350PubMed Chuang VP, Wallace S, Stroehlein J, Yap HY, Patt YZ (1981) Hepatic artery infusion chemotherapy: Gastroduodenal complications. AJR Am J Roentgenol 137:347–350PubMed
7.
go back to reference Granmayeh M, Wallace S, Schwarten D (1979) Transcatheter occlusion of the gastroduodenal artery. Radiology 131:59–64PubMed Granmayeh M, Wallace S, Schwarten D (1979) Transcatheter occlusion of the gastroduodenal artery. Radiology 131:59–64PubMed
8.
go back to reference Cohen AM, Greenfield A, Wood WC, Waltman A, Novelline R, Athanasoulis C, Schaeffer NJ (1983) Treatment of hepatic metastases by transaxillary hepatic artery chemotherapy using an implanted drug pump. Cancer 51:2013–2019PubMedCrossRef Cohen AM, Greenfield A, Wood WC, Waltman A, Novelline R, Athanasoulis C, Schaeffer NJ (1983) Treatment of hepatic metastases by transaxillary hepatic artery chemotherapy using an implanted drug pump. Cancer 51:2013–2019PubMedCrossRef
9.
go back to reference Fiorentini G, Poddie DB, De Giorgi U, Guglielminetti D, Giovanis P, Leoni M, Latino W, Dazzi C, Cariello A, Turci D, Marangolo M (2000) Global approach to hepatic metastases from colorectal cancer: indication and outcome of intra-arterial chemotherapy and other hepatic-directed treatments. Med Oncol 17:163–173PubMed Fiorentini G, Poddie DB, De Giorgi U, Guglielminetti D, Giovanis P, Leoni M, Latino W, Dazzi C, Cariello A, Turci D, Marangolo M (2000) Global approach to hepatic metastases from colorectal cancer: indication and outcome of intra-arterial chemotherapy and other hepatic-directed treatments. Med Oncol 17:163–173PubMed
10.
go back to reference Doria MI Jr, Doria LK, Faintuch J, Levin B (1994) Gastric mucosal injury after hepatic arterial infusion chemotherapy with floxuridine: A clinical and pathologic study. Cancer 73:2042–2047PubMedCrossRef Doria MI Jr, Doria LK, Faintuch J, Levin B (1994) Gastric mucosal injury after hepatic arterial infusion chemotherapy with floxuridine: A clinical and pathologic study. Cancer 73:2042–2047PubMedCrossRef
11.
go back to reference Narsete T, Ansfield F, Wirtanen G, Ramirez G, Wolberg W, Jarrett F (1977) Gastric ulceration in patients receiving intrahepatic infusion of 5-fluorouracil. Ann Surg 186:734–736PubMedCrossRef Narsete T, Ansfield F, Wirtanen G, Ramirez G, Wolberg W, Jarrett F (1977) Gastric ulceration in patients receiving intrahepatic infusion of 5-fluorouracil. Ann Surg 186:734–736PubMedCrossRef
12.
go back to reference Niederhuber JE, Ensminger WD (1983) Surgical considerations in the management of hepatic neoplasia. Semin Oncol 10:135–147PubMed Niederhuber JE, Ensminger WD (1983) Surgical considerations in the management of hepatic neoplasia. Semin Oncol 10:135–147PubMed
13.
go back to reference Yamagami T, Nakamura T, Iida S, Kato T, Nishimura T (2002) Embolization of the right gastric artery before hepatic arterial infusion chemotherapy to prevent gastric mucosal lesions: Approach through the hepatic artery versus the left gastric artery. AJR Am J Roentgenol 179:1605–1610PubMed Yamagami T, Nakamura T, Iida S, Kato T, Nishimura T (2002) Embolization of the right gastric artery before hepatic arterial infusion chemotherapy to prevent gastric mucosal lesions: Approach through the hepatic artery versus the left gastric artery. AJR Am J Roentgenol 179:1605–1610PubMed
14.
go back to reference Inaba Y, Arai Y, Matsueda K, Takeuchi Y, Aramaki T (2001) Right gastric artery embolization to prevent acute gastric mucosal lesions in patients undergoing repeat hepatic arterial infusion chemotherapy. J Vasc Interv Radiol 12:957–963PubMed Inaba Y, Arai Y, Matsueda K, Takeuchi Y, Aramaki T (2001) Right gastric artery embolization to prevent acute gastric mucosal lesions in patients undergoing repeat hepatic arterial infusion chemotherapy. J Vasc Interv Radiol 12:957–963PubMed
15.
go back to reference Hashimoto M, Heianna J, Tate E, Kurosawa R, Nishii T, Mayama I (2001) The feasibility of retrograde catheterization of the right gastric artery via the left gastric artery. J Vasc Interv Radiol 12:1103–1106PubMed Hashimoto M, Heianna J, Tate E, Kurosawa R, Nishii T, Mayama I (2001) The feasibility of retrograde catheterization of the right gastric artery via the left gastric artery. J Vasc Interv Radiol 12:1103–1106PubMed
16.
go back to reference Kiyosue H, Matsumoto S, Hori Y, Okahara M, Sagara Y, Mori H (2004) Turnback technique with use of a shaped microcatheter for superselective catheterization of arteries originating at acute angles. J Vasc Interv Radiol 15:641–643PubMed Kiyosue H, Matsumoto S, Hori Y, Okahara M, Sagara Y, Mori H (2004) Turnback technique with use of a shaped microcatheter for superselective catheterization of arteries originating at acute angles. J Vasc Interv Radiol 15:641–643PubMed
17.
go back to reference Sangro B, Boan J, Martinez de la Cuesta A, Kennedy A (2004) Irradiación hepática selectiva con microesferas cargadas con Ytrio. Oncologia 27:106–108CrossRef Sangro B, Boan J, Martinez de la Cuesta A, Kennedy A (2004) Irradiación hepática selectiva con microesferas cargadas con Ytrio. Oncologia 27:106–108CrossRef
18.
go back to reference Geschwind JF, Salem R, Carr BI, Soulen MC, Thurston KG, Goin KA, Van Buskirk M, Roberts CA, Goin JE (2004) Yttrium-90 microspheres for the treatment of hepatocellular carcinoma. Gastroenterology 127:S194–205PubMedCrossRef Geschwind JF, Salem R, Carr BI, Soulen MC, Thurston KG, Goin KA, Van Buskirk M, Roberts CA, Goin JE (2004) Yttrium-90 microspheres for the treatment of hepatocellular carcinoma. Gastroenterology 127:S194–205PubMedCrossRef
19.
20.
go back to reference Nakamura H, Hashimoto T, Oi H, Sawada S, Furui S (1991) Prevention of gastric complications in hepatic arterial chemoembolization: Balloon catheter occlusion technique. Acta Radiol 32:81–82PubMedCrossRef Nakamura H, Hashimoto T, Oi H, Sawada S, Furui S (1991) Prevention of gastric complications in hepatic arterial chemoembolization: Balloon catheter occlusion technique. Acta Radiol 32:81–82PubMedCrossRef
21.
go back to reference Wells JJ, Nostrant TT, Wilson JA, Gyves JW (1985) Gastroduodenal ulcerations in patients receiving selective hepatic artery infusion chemotherapy. Am J Gastroenterol 80:425–429PubMed Wells JJ, Nostrant TT, Wilson JA, Gyves JW (1985) Gastroduodenal ulcerations in patients receiving selective hepatic artery infusion chemotherapy. Am J Gastroenterol 80:425–429PubMed
22.
go back to reference Geschwind JF, Ramsey DE, van der Wal BC, Kobeiter H, Juluru K, Hartnell GG, Choti MA (2003) Transcatheter arterial chemoembolization of liver tumors: Effects of embolization protocol on injectable volume of chemotherapy and subsequent arterial patency. Cardiovasc Intervent Radiol 26:111–17PubMedCrossRef Geschwind JF, Ramsey DE, van der Wal BC, Kobeiter H, Juluru K, Hartnell GG, Choti MA (2003) Transcatheter arterial chemoembolization of liver tumors: Effects of embolization protocol on injectable volume of chemotherapy and subsequent arterial patency. Cardiovasc Intervent Radiol 26:111–17PubMedCrossRef
23.
go back to reference Yip D, Allen R, Ashton C, Jain S (2004) Radiation-induced ulceration of the stomach secondary to hepatic embolization with radioactive yttrium microspheres in the treatment of metastatic colon cancer. J Gastroenterol Hepatol 19:347–349PubMedCrossRef Yip D, Allen R, Ashton C, Jain S (2004) Radiation-induced ulceration of the stomach secondary to hepatic embolization with radioactive yttrium microspheres in the treatment of metastatic colon cancer. J Gastroenterol Hepatol 19:347–349PubMedCrossRef
24.
go back to reference Arai Y, Inaba Y, Takeuchi Y (1997) Interventional techniques for hepatic arterial infusion chemotherapy. In: Castaneda-Zuniga WR (ed) Interventional radiology, 3rd edn. Williams & Wilkins, Baltimore, pp 192–205 Arai Y, Inaba Y, Takeuchi Y (1997) Interventional techniques for hepatic arterial infusion chemotherapy. In: Castaneda-Zuniga WR (ed) Interventional radiology, 3rd edn. Williams & Wilkins, Baltimore, pp 192–205
25.
go back to reference Daseler EH, Anson BJ, Hambley WC, Reimann AF (1947) The cystic artery and constituents of the hepatic pedicle: A study of 500 specimens. Surg Gynecol Obstet 85:47–63 Daseler EH, Anson BJ, Hambley WC, Reimann AF (1947) The cystic artery and constituents of the hepatic pedicle: A study of 500 specimens. Surg Gynecol Obstet 85:47–63
26.
go back to reference Miyayama S, Matsui O, Taki K, Minami T, Ryu Y, Ito C, Nakamura K, Inoue D, Notsumata K, Toya D, Tanaka N, Mitsui T (2006) Extrahepatic blood supply to hepatocellular carcinoma: angiographic demonstration and transcatheter arterial chemoembolization. Cardiovasc Intervent Radiol 29:39–48PubMedCrossRef Miyayama S, Matsui O, Taki K, Minami T, Ryu Y, Ito C, Nakamura K, Inoue D, Notsumata K, Toya D, Tanaka N, Mitsui T (2006) Extrahepatic blood supply to hepatocellular carcinoma: angiographic demonstration and transcatheter arterial chemoembolization. Cardiovasc Intervent Radiol 29:39–48PubMedCrossRef
Metadata
Title
Right Gastric Artery Embolization Prior to Treatment with Yttrium-90 Microspheres
Authors
Octavio Cosin
Jose Ignacio Bilbao
Sergio Alvarez
Esther de Luis
Alberto Alonso
Antonio Martinez-Cuesta
Publication date
01-02-2007
Publisher
Springer-Verlag
Published in
CardioVascular and Interventional Radiology / Issue 1/2007
Print ISSN: 0174-1551
Electronic ISSN: 1432-086X
DOI
https://doi.org/10.1007/s00270-006-0028-5

Other articles of this Issue 1/2007

CardioVascular and Interventional Radiology 1/2007 Go to the issue