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CardioVascular and Interventional Radiology

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01-11-2003 | Case Report

Use of the Trellis™ Peripheral Infusion System for Enhancement of rt-PA Thrombolysis in Acute Lower Limb Ischemia

Authors: Dimitrios K. Tsetis, Asterios N. Katsamouris, Zacharias Androulakakis, Konstantinos Chamalakis, Theodoros Kostas, Konstantinos Chlapoutakis, Nicholas C. Gourtsoyiannis

Published in: CardioVascular and Interventional Radiology | Issue 6/2003

Abstract

The Trellis™ Peripheral Infusion System is an over-the-wire 0.035″ guidewire compatible device, designed to isolate a region of the peripheral vasculature to allow for lytic drug infusion and dispersion. We used it successfully through a percutaneous approach in two cases of acute thrombosis of a native lower limb artery. The total amount of rt-PA used was 12 and 9 mg, respectively and was delivered through bolus injections obviating the need for a supplementary continuous infusion of the agent. The time for dissolution of thrombus was 45 and 35 minutes, respectively. No complications were observed.

Working Party on Thrombolysis in the management of limb ischemia1998Thrombolysis in the management of lower limb peripheral arterial occlusion: a consensus document.Am J Cardiol81207218

McNamara, T, Goodwin, S, Kandarpa, K 1994Complications of thrombolysis.Semin Interv Radiol11134144

Jorgensen, B, Tonnesen, KH, Bulow, J, Nielsen, JD, Jorgensen, M, Holstein, P, Anderse, E 1989Femoral artery recanalization with percutaneous angioplasty and segmentally enclosed plasminogen activator.Lancet2011061108CrossRef

Tonnesen, KH, Holstein, P, Andersen, E 1991emoro-popliteal artery occlusions treated by percutaneous transluminal angioplasty and enclosed thrombolysis: results in 55 patients.Eur J Vasc Surg5429434PubMed

Vina, RF, Benetti, F, Vrsalovick, F, Rizzardi, JL, Petroni, D, de Zappetti, M, Zappetti, A, Leeflang, S 2002Percutaneous infusion system for in situ thrombolysis in the abdominal aorta and iliac arteries.J Endovasc Ther9932935CrossRefPubMed

Swischuk, JL, Fox, PF, Young, K, Nussan, S, Mouse, B, Castaneda, F, Brady, TM 2001Transcatheter intraarterial infusion of rt-PA for acute lower limb ischemia: results and complications.J Vasc Interv Radiol12423430PubMed

Rao, AK, Pratt, C, Berke, A, Jaffe, A, Ockene, I, Schreiber, TL, Bell, WR, Knalterud, G, Robertson, TL, Terrin, ML 1988Thrombolysis in myocardial infarction (TIMI) trial-phase1: hemorrhagic manifestations and changes in plasma fibrinogen and the fibrinolytic system in patients treated with recombinant tissue plasminogen activator and streptokinase.J Am Coll Cardiol11111PubMed

Weitz, JI 1996Limited fibrin specificity of tissue-type plasminogen activator and its potential link to bleeding.J Vasc Interv Radiol618S23S

Verstraete M, Bounameaux H, De Cock, Van de Werf E, Cohen D (1985) Pharmacokinetics and systemic fibrinogenolytic effects of recombinant tissue-type plasminogen activator (rt-PA) in humans. J Pharmacol Exp Ther 235:506–512. PubMed

10.

Braithwaite, BD, Buckenham, TM, Galland, RB, Heather, BP, Earnshaw, JJ 1997Prospective randomized trial of high-dose bolus versus low-dose tissue plasminogen activator infusion in the management of acute limb ischemia.Br J Surg84646650CrossRefPubMed

11.

Ward, AS, Andaz, SK, Bygrave, S 1994Thrombolysis with tissue-plasminogen activator: results with a high-dose transthrombus technique.J Vasc Surg19503508PubMed

12.

Rauber, K, Heidinger, KS, Kemkes-Matthes, B 1997Coagulation alterations due to local fibrinolytic therapy with recombinant tissue-type plasminogen activator (rt-PA) in patients with peripheral arterial occlusive disease.Cardiovasc Intervent Radiol20169173CrossRefPubMed

13.

Hall, TB, Matson, M, Belli, AM 2001Thrombolysis in the peripheral vascular system.Eur Radio11439445CrossRef

14.

Morgan, R, Belli, AM 2002Percutaneous thrombectomy: a review.Eur Radiol12205217CrossRefPubMed

15.

Zana, K, Otal, P, Fornet, B, Forrai, G, Chabbert, V, Smayra, T, Joffre, F, Rousseau, H 2001In vitro evaluation of a new rotational thrombectomy device: the Straub Rotarex Catheter.Cardiovasc Intervent Radiol24319323CrossRefPubMed

Title: Use of the Trellis™ Peripheral Infusion System for Enhancement of rt-PA Thrombolysis in Acute Lower Limb Ischemia
Authors: Dimitrios K. Tsetis
Asterios N. Katsamouris
Zacharias Androulakakis
Konstantinos Chamalakis
Theodoros Kostas
Konstantinos Chlapoutakis
Nicholas C. Gourtsoyiannis
Publication date: 01-11-2003
Publisher: Springer-Verlag
Published in: CardioVascular and Interventional Radiology / Issue 6/2003
Print ISSN: 0174-1551
Electronic ISSN: 1432-086X
DOI: https://doi.org/10.1007/s00270-003-0033-x

At a glance: The STEP trials

Springer Medicine

Use of the Trellis™ Peripheral Infusion System for Enhancement of rt-PA Thrombolysis in Acute Lower Limb Ischemia

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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