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01-12-2021 | Metastasis | Original Scientific Report

Impact of Lymph Node Metastases Around the Superior Mesenteric Artery on Postoperative Outcomes of Pancreatic Head Cancer

Authors: Yoichi Miyata, Naoto Yonamine, Ibuki Fujinuma, Takazumi Tsunenari, Yasuhiro Takihata, Toshimitsu Iwasaki, Takahiro Einama, Hironori Tsujimoto, Hideki Ueno, Junji Yamamoto, Yoji Kishi

Published in: World Journal of Surgery | Issue 12/2021

Abstract

Background

The neural plexus and lymph nodes around the superior mesenteric artery (LN#14), are the most frequent sites involved by pancreatic head cancer. However the influence of metastases to LN#14 on patients’ prognosis has rarely been evaluated.

Methods

The patients who underwent pancreatectomy for pancreatic head cancer between January 2010 and December 2018 were selected. The patients with nodal metastases were classified into an LN#14 + or LN#14−group according to LN#14 metastasis. Clinical and pathological characteristics and prognosis were compared between the two groups.

Results

In total, 99 patients underwent pancreatectomy. Ninety-four patients were positive for lymph node metastases and 14 and 80 were classified as LN#14 + and LN#14 − , respectively. Postoperative median overall survival (OS) of the LN#14 + and LN#14 − groups was 10.2 and 31.1 months, respectively (P < 0.001). Median OS of the LN#14 + group was worse than that of patients with ≥ 4 metastatic nodes in the LN#14 − group (n = 35, 24.7 months, P = 0.002). In multivariate analysis, LN#14 + (hazard ratio [HR] = 3.89, 95% confidence interval [CI], 1.64–8.86) was one of the independent predictors of worse OS.

Conclusion

It might be feasible to recognize LN#14 metastases as an important prognostic factor independently from other regional lymph node metastases.

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Title: Impact of Lymph Node Metastases Around the Superior Mesenteric Artery on Postoperative Outcomes of Pancreatic Head Cancer
Authors: Yoichi Miyata
Naoto Yonamine
Ibuki Fujinuma
Takazumi Tsunenari
Yasuhiro Takihata
Toshimitsu Iwasaki
Takahiro Einama
Hironori Tsujimoto
Hideki Ueno
Junji Yamamoto
Yoji Kishi
Publication date: 01-12-2021
Publisher: Springer International Publishing
Keywords: Metastasis
Pancreatectomy
Published in: World Journal of Surgery / Issue 12/2021
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-021-06276-0

ACC 2024 Congress

Springer Medicine

Impact of Lymph Node Metastases Around the Superior Mesenteric Artery on Postoperative Outcomes of Pancreatic Head Cancer

Abstract

Background

Methods

Results

Conclusion

ACC 2024 Congress

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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