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World Journal of Surgery
Published in: World Journal of Surgery 10/2020

01-10-2020 | NSCLC | Original Scientific Report

Inflammatory Risk Factors for Early Recurrence of Non-Small Cell Lung Cancer Within One Year Following Curative Resection

Authors: Satoru Kobayashi, Yoko Karube, Yuji Matsumura, Morimichi Nishihira, Takashi Inoue, Osamu Araki, Sumiko Maeda, Masayuki Chida

Published in: World Journal of Surgery | Issue 10/2020

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Abstract

Background

Several inflammation-based scoring systems and nutritional indicators have been shown to have relevance to survival of patients with non-small cell lung cancer (NSCLC).The present study examined preoperative and pathological factors in patients who underwent curative resection for non-small cell lung cancer, with the aim to elucidate risk factors for early recurrence within 1 year of surgery.

Methods

Patients with NSCLC who underwent surgery from January 2009 to December 2014 were retrospectively investigated. Routine laboratory measurements including carcinoembryonic antigen were performed before surgery, and pathological information was collected after surgery. Patients with recurrence within 1 year after surgery were considered as early recurrence group (ERG), those with recurrence after 1 year were as late recurrence group (LRG), and those without recurrence were as no recurrence group (NRG).

Results

Multivariate analysis between ERG and LRG revealed Glasgow prognostic score (GPS) and CRP-to-albumin ratio (CAR) as independent risk factors for early recurrence. Multivariate analysis between ERG and LRG + NRG confirmed CAR, vascular invasion, and pathological stage as risk factors for early recurrence.

Conclusion

These findings indicated that CAR and GPS were confirmed to be risk factors for early recurrence, in addition to pathological factors.
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Metadata
Title
Inflammatory Risk Factors for Early Recurrence of Non-Small Cell Lung Cancer Within One Year Following Curative Resection
Authors
Satoru Kobayashi
Yoko Karube
Yuji Matsumura
Morimichi Nishihira
Takashi Inoue
Osamu Araki
Sumiko Maeda
Masayuki Chida
Publication date
01-10-2020
Publisher
Springer International Publishing
Keywords
NSCLC
NSCLC
Published in
World Journal of Surgery / Issue 10/2020
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI
https://doi.org/10.1007/s00268-020-05612-0

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