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Published in: World Journal of Surgery 8/2020

01-08-2020 | Emergency Medicine | Original Scientific Report

The Decreasing Incidence of Acute Appendicitis During COVID-19: A Retrospective Multi-centre Study

Authors: James Tankel, Aner Keinan, Ori Blich, Michael Koussa, Brigitte Helou, Shahaf Shay, Diaa Zugayar, Alon Pikarsky, Haggi Mazeh, Ram Spira, Petachia Reissman

Published in: World Journal of Surgery | Issue 8/2020

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Abstract

Background

As the novel coronavirus disease 19 (COVID-19) spreads, a decrease in the number of patients with acute appendicitis (AA) has been noted in our institutions. The aim of this study was to compare the incidence and severity of AA before and during the COVID-19 pandemic.

Methods

A retrospective cohort analysis was performed between December 2019 and April 2020 in the four high-volume centres that provide health care to the municipality of Jerusalem, Israel. Two groups were created. Group A consisted of patients who presented in the 7 weeks prior to COVID-19 first being diagnosed, whilst those in the 7 weeks after were allocated to Group B. A comparison was performed between the clinicopathological features of the patients in each group as was the changing incidence of AA.

Results

A total of 378 patients were identified, 237 in Group A and 141 in Group B (62.7% vs. 37.3%). Following the onset of COVID-19, the weekly incidence of AA decreased by 40.7% (p = 0.02). There was no significant difference between the groups in terms of the length of preoperative symptoms or surgery, need for postoperative peritoneal drainage or the distribution of complicated versus uncomplicated appendicitis.

Conclusions

The significant decrease in the number of patients admitted with AA during the onset of COVID-19 possibly represents successful resolution of mild appendicitis treated symptomatically by patients at home. Further research is needed to corroborate this assumption and identify those patients who may benefit from this treatment pathway.
Literature
1.
go back to reference Wu Z, McGoogan JM (2020) Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China. JAMA, 24 [Epub ahead of print] Wu Z, McGoogan JM (2020) Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China. JAMA, 24 [Epub ahead of print]
2.
go back to reference Cervellin G, Mora R, Ticinesi A, Meschi T, Comelli I, Catena F et al (2016) Epidemiology and outcomes of acute abdominal pain in a large urban Emergency Department: Retrospective analysis of 5,340 cases. Ann Transl Med 4(19):362CrossRef Cervellin G, Mora R, Ticinesi A, Meschi T, Comelli I, Catena F et al (2016) Epidemiology and outcomes of acute abdominal pain in a large urban Emergency Department: Retrospective analysis of 5,340 cases. Ann Transl Med 4(19):362CrossRef
3.
go back to reference Addiss DG, Shaffer N, Fowler BS, Tauxe RV (1990) The epidemiology of appendicitis and appendectomy in the United States. Am J Epidemiol 132(5):910–925CrossRef Addiss DG, Shaffer N, Fowler BS, Tauxe RV (1990) The epidemiology of appendicitis and appendectomy in the United States. Am J Epidemiol 132(5):910–925CrossRef
4.
go back to reference Johnston MJ, Fitzgerald JEF, Bhangu A, Greaves NS, Prew CL, Fraser I (2014) Outpatient management of biliary colic: a prospective observational study of prescribing habits and analgesia effectiveness. Int J Surg 12(2):169–176CrossRef Johnston MJ, Fitzgerald JEF, Bhangu A, Greaves NS, Prew CL, Fraser I (2014) Outpatient management of biliary colic: a prospective observational study of prescribing habits and analgesia effectiveness. Int J Surg 12(2):169–176CrossRef
5.
go back to reference Humes DJ (2012) Diagnosing and managing acute diverticulitis. Practitioner 256(1753):21–22PubMed Humes DJ (2012) Diagnosing and managing acute diverticulitis. Practitioner 256(1753):21–22PubMed
6.
go back to reference Schanzer DL, Schwartz B (2013) Impact of seasonal and pandemic influenza on emergency department visits, 2003–2010, Ontario. Canada Acad Emerg Med 20(4):388–397CrossRef Schanzer DL, Schwartz B (2013) Impact of seasonal and pandemic influenza on emergency department visits, 2003–2010, Ontario. Canada Acad Emerg Med 20(4):388–397CrossRef
7.
go back to reference Paek SH, Kim DK, Lee JH, Kwak YH (2017) The impact of middle east respiratory syndrome outbreak on trends in emergency department utilization patterns. J Korean Med Sci 32(10):1576–1580CrossRef Paek SH, Kim DK, Lee JH, Kwak YH (2017) The impact of middle east respiratory syndrome outbreak on trends in emergency department utilization patterns. J Korean Med Sci 32(10):1576–1580CrossRef
8.
go back to reference Stein GY, Rath-Wolfson L, Zeidman A, Atar E, Marcus O, Joubran S et al (2012) Sex differences in the epidemiology, seasonal variation, and trends in the management of patients with acute appendicitis. Langenbeck’s Arch Surg 397(7):1087–1092CrossRef Stein GY, Rath-Wolfson L, Zeidman A, Atar E, Marcus O, Joubran S et al (2012) Sex differences in the epidemiology, seasonal variation, and trends in the management of patients with acute appendicitis. Langenbeck’s Arch Surg 397(7):1087–1092CrossRef
9.
go back to reference Ferris M, Quan S, Kaplan BS, Molodecky N, Ball CG, Chernoff GW et al (2017) The global incidence of appendicitis: a systematic review of population-based studies. Ann Surg 266(2):237–241CrossRef Ferris M, Quan S, Kaplan BS, Molodecky N, Ball CG, Chernoff GW et al (2017) The global incidence of appendicitis: a systematic review of population-based studies. Ann Surg 266(2):237–241CrossRef
10.
go back to reference Cunha BA, Pherez FM, Durie N (2010) Swine influenza (H1N1) and acute appendicitis. Hear Lung J Acute Crit Care 29(6):544–546CrossRef Cunha BA, Pherez FM, Durie N (2010) Swine influenza (H1N1) and acute appendicitis. Hear Lung J Acute Crit Care 29(6):544–546CrossRef
11.
go back to reference Alenazi TH, Al Arbash H, El-Saed A, Alshamrani MM, Baffoe-Bonnie H, Arabi YM et al (2017) Identified transmission dynamics of middle east respiratory syndrome coronavirus infection during an outbreak: implications of an overcrowded emergency department. Clin Infect Dis 65(4):675–679CrossRef Alenazi TH, Al Arbash H, El-Saed A, Alshamrani MM, Baffoe-Bonnie H, Arabi YM et al (2017) Identified transmission dynamics of middle east respiratory syndrome coronavirus infection during an outbreak: implications of an overcrowded emergency department. Clin Infect Dis 65(4):675–679CrossRef
12.
go back to reference Hastings DL, Tokars JI, Abdel Aziz IZAM, Alkhaldi KZ, Bensadek AT, Alraddadi BM (2016) Outbreak of middle east respiratory syndrome at tertiary care hospital, Jeddah, Saudi Arabia, 2014. Emerg Infect Dis 22(5):794–801CrossRef Hastings DL, Tokars JI, Abdel Aziz IZAM, Alkhaldi KZ, Bensadek AT, Alraddadi BM (2016) Outbreak of middle east respiratory syndrome at tertiary care hospital, Jeddah, Saudi Arabia, 2014. Emerg Infect Dis 22(5):794–801CrossRef
13.
go back to reference Assiri A, McGeer A, Perl TM, Price CS, Al Rabeeah AA, Cummings DAT et al (2013) Hospital outbreak of middle east respiratory syndrome coronavirus. N Engl J Med 369:407–416CrossRef Assiri A, McGeer A, Perl TM, Price CS, Al Rabeeah AA, Cummings DAT et al (2013) Hospital outbreak of middle east respiratory syndrome coronavirus. N Engl J Med 369:407–416CrossRef
14.
go back to reference Williams N, Bello M (1998) Perforation rate relates to delayed presentation in childhood acute appendicitis. J R Coll Surg Edinb 43(2):101–102PubMed Williams N, Bello M (1998) Perforation rate relates to delayed presentation in childhood acute appendicitis. J R Coll Surg Edinb 43(2):101–102PubMed
15.
go back to reference Kearney D, Cahill RA, O’Brien E, Kirwan WO, Redmond HP (2008) Influence of delays on perforation risk in adults with acute appendicitis. Dis Colon Rectum 51(12):1823–1827CrossRef Kearney D, Cahill RA, O’Brien E, Kirwan WO, Redmond HP (2008) Influence of delays on perforation risk in adults with acute appendicitis. Dis Colon Rectum 51(12):1823–1827CrossRef
16.
go back to reference Di Saverio S, Sibilio A, Giorgini E, Biscardi A, Villani S, Coccolini F et al (2014) The NOTA study (non operative treatment for acute appendicitis): Prospective study on the efficacy and safety of antibiotics (amoxicillin and clavulanic acid) for treating patients with right lower quadrant abdominal pain and long-term follow-up of conservatively treated suspected appendicitis. Ann Surg 260(1):109–117CrossRef Di Saverio S, Sibilio A, Giorgini E, Biscardi A, Villani S, Coccolini F et al (2014) The NOTA study (non operative treatment for acute appendicitis): Prospective study on the efficacy and safety of antibiotics (amoxicillin and clavulanic acid) for treating patients with right lower quadrant abdominal pain and long-term follow-up of conservatively treated suspected appendicitis. Ann Surg 260(1):109–117CrossRef
17.
go back to reference Armstrong J, Merritt N, Jones S, Scott L, Bütter A (2014) Non-operative management of early, acute appendicitis in children: Is it safe and effective? J Pediatr Surg 49(5):782–785CrossRef Armstrong J, Merritt N, Jones S, Scott L, Bütter A (2014) Non-operative management of early, acute appendicitis in children: Is it safe and effective? J Pediatr Surg 49(5):782–785CrossRef
18.
go back to reference Georgiou R, Eaton S, Stanton MP, Pierro A, Hall NJ (2017) Efficacy and safety of nonoperative treatment for acute appendicitis: a meta-analysis. Pediatrics 39(3):e20163003CrossRef Georgiou R, Eaton S, Stanton MP, Pierro A, Hall NJ (2017) Efficacy and safety of nonoperative treatment for acute appendicitis: a meta-analysis. Pediatrics 39(3):e20163003CrossRef
19.
go back to reference Park HC, Kim MJ, Lee BH (2017) Randomized clinical trial of antibiotic therapy for uncomplicated appendicitis. Br J Surg 104(13):1785–1790CrossRef Park HC, Kim MJ, Lee BH (2017) Randomized clinical trial of antibiotic therapy for uncomplicated appendicitis. Br J Surg 104(13):1785–1790CrossRef
20.
go back to reference Kirshenbaum M, Mishra V, Kuo D, Kaplan G (2003) Resolving appendicitis: role of CT. Abdom Imaging 28(2):276–279CrossRef Kirshenbaum M, Mishra V, Kuo D, Kaplan G (2003) Resolving appendicitis: role of CT. Abdom Imaging 28(2):276–279CrossRef
Metadata
Title
The Decreasing Incidence of Acute Appendicitis During COVID-19: A Retrospective Multi-centre Study
Authors
James Tankel
Aner Keinan
Ori Blich
Michael Koussa
Brigitte Helou
Shahaf Shay
Diaa Zugayar
Alon Pikarsky
Haggi Mazeh
Ram Spira
Petachia Reissman
Publication date
01-08-2020
Publisher
Springer International Publishing
Published in
World Journal of Surgery / Issue 8/2020
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI
https://doi.org/10.1007/s00268-020-05599-8

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