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01-10-2018 | Original Scientific Report

Management and Outcome of Liver Abscesses After Liver Transplantation

Authors: Iago Justo, Carlos Jiménez-Romero, Alejandro Manrique, Oscar Caso, Jorge Calvo, Felix Cambra, Alberto Marcacuzco

Published in: World Journal of Surgery | Issue 10/2018

Abstract

Background

Liver abscess after orthotopic liver transplantation (OLT) is a rare, life-threatening complication. The aim of this study is to analyze the incidence, risk factors, clinical manifestations, treatment and outcomes of liver abscesses after OLT.

Methods

We perform a retrospective review of the patients who developed one or more liver abscesses among a series of 984 patients who underwent OLT between January 2000 and December 2016.

Results

Fourteen patients (1.5%) developed 18 episodes of liver abscesses, and the median time from OLT to the diagnosis of liver abscess was 39.7 months. Major predisposing factors were biliary strictures in 11 patients, hepatic artery thrombosis in 8, re-OLT in 3, choledochojejunostomy in 2, living donor OLT in 2, donor after cardiac death in 1, split liver in 1, and liver biopsy in 1. All patients were managed by intravenous antibiotics; percutaneous drainage was performed in 10 patients, while 2 patients underwent re-OLT. The mortality rate related to liver abscesses was 21.4%. The mean hospital stay was 30 ± 19 days, and during a mean follow-up of 93 ± 78 months, three other patients died.

Conclusions

Liver abscesses must be managed with antibiotic therapy and percutaneous drainage, but when these conservative measures fail (persistent abscess and sepsis), a re-OLT must be performed in order to prevent the high mortality associated with this severe complication.

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Title: Management and Outcome of Liver Abscesses After Liver Transplantation
Authors: Iago Justo
Carlos Jiménez-Romero
Alejandro Manrique
Oscar Caso
Jorge Calvo
Felix Cambra
Alberto Marcacuzco
Publication date: 01-10-2018
Publisher: Springer International Publishing
Published in: World Journal of Surgery / Issue 10/2018
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-018-4622-x

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Management and Outcome of Liver Abscesses After Liver Transplantation

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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