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World Journal of Surgery

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01-08-2018 | Original Scientific Report

Adrenal Ganglioneuroma: Features and Outcomes of 42 Cases in a Chinese Population

Authors: Jing Xie, Jun Dai, Wen-long Zhou, Fu-kang Sun

Published in: World Journal of Surgery | Issue 8/2018

Abstract

Background

Adrenal ganglioneuromas (AGNs) are extremely rare benign neoplasms. This study is to share our experience regarding diagnostic and operative management of these tumors.

Methods

Clinical details as well as follow-up data were retrospectively analyzed in 42 primary AGN patients who received operative resection at a tertiary referral hospital in China between May 2005 and July 2016.

Results

The mean age of the patients at diagnosis was 35.3 years (range 13–59 years). Among the patients, 28 were asymptomatic. The mean preoperative size was 5.3 ± 2.2 cm (range 2.1–14.0 cm), and 17 cases were larger than 5 cm. All patients underwent operative resection as open adrenalectomy in 20 patients and laparoscopy in 22 patients. The mean tumor size on pathologic examination was 6.0 ± 2.6 cm (range 2.2–17.0 cm). Laparoscopic operation showed its advantages over open surgery on the postoperative duration (5.0 vs. 7.3 days, p < 0.001) and estimated blood loss (69.5 vs. 157.5 ml, p = 0.047). No patient had recurrence or metastasis during a median follow-up of 70.5 months (range 3.7–164.3 months).

Conclusions

We describe the largest AGN series reported to date. The preoperative diagnosis of AGN remains difficult despite of the progression of imaging examination. After complete resection, the prognosis of AGN patients is excellent. Laparoscopic approach has its advantages in the resection of AGNs.

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Title: Adrenal Ganglioneuroma: Features and Outcomes of 42 Cases in a Chinese Population
Authors: Jing Xie
Jun Dai
Wen-long Zhou
Fu-kang Sun
Publication date: 01-08-2018
Publisher: Springer International Publishing
Published in: World Journal of Surgery / Issue 8/2018
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-018-4499-8

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Adrenal Ganglioneuroma: Features and Outcomes of 42 Cases in a Chinese Population

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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