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World Journal of Surgery
Published in: World Journal of Surgery 12/2017

01-12-2017 | Original Scientific Report

Pheochromocytoma with Synchronous Ipsilateral Adrenal Cortical Adenoma

Authors: M. Earth Hasassri, T. K. Pandian, Aleh A. Bobr, Irina Bancos, William F. Young Jr., Melanie L. Richards, David R. Farley, Geoffrey B. Thompson, Travis J. McKenzie

Published in: World Journal of Surgery | Issue 12/2017

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Abstract

Background

Pheochromocytoma with synchronous ipsilateral adrenal cortical adenoma (PSCA) may present with mixed clinical, biochemical, and radiological features characteristic to each neoplasm subtype.

Methods

All patients with a pathological diagnosis of pheochromocytoma were evaluated for an ipsilateral cortical adenoma from 1994 through 2015. Retrospectively extracted data included indications for adrenalectomy, diagnostic workup (biochemical and radiographic), operative characteristics, pathological findings, and postoperative complications.

Results

Sixteen of 413 patients (4%) undergoing adrenalectomy for pheochromocytoma had a PSCA. Median patient age was 57.7 years (IQR 50.1, 63.1); 50% were male. On imaging, 75% of the adrenal neoplasms were found incidentally and only 50% were reported to have a synchronous ipsilateral neoplasm based on imaging findings. Clinically important cortical hormone secretion was diagnosed in 38% of these patients; 25% had glucocorticoid secretory autonomy; and 13% had primary aldosteronism.

Conclusion

Physicians should be aware that adrenal neoplasms with mixed diagnostic findings may represent PSCA. Evaluation should be performed on this co-occurrence to prevent perioperative complications from resection of an unexpected secretory cortical neoplasm.
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Metadata
Title
Pheochromocytoma with Synchronous Ipsilateral Adrenal Cortical Adenoma
Authors
M. Earth Hasassri
T. K. Pandian
Aleh A. Bobr
Irina Bancos
William F. Young Jr.
Melanie L. Richards
David R. Farley
Geoffrey B. Thompson
Travis J. McKenzie
Publication date
01-12-2017
Publisher
Springer International Publishing
Published in
World Journal of Surgery / Issue 12/2017
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI
https://doi.org/10.1007/s00268-017-4110-8

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