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World Journal of Surgery

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01-04-2017 | Original Scientific Report

Is C-11 Methionine PET/CT Able to Localise Sestamibi-Negative Parathyroid Adenomas?

Authors: Theresia Weber, Martin Gottstein, Sabrina Schwenzer, Ambros Beer, Markus Luster

Published in: World Journal of Surgery | Issue 4/2017

Abstract

Background

Patients with primary hyperparathyroidism (pHPT) and a negative preoperative Tc-99 sestamibi (MIBI) scintigraphy are considered to have a higher risk of persistent disease. The aim of this study was to assess whether additional imaging with C-11 methionine positron emission tomography/computed tomography (Met-PET/CT) is able to localise sestamibi-negative hyperfunctioning parathyroid glands.

Methods

In 50 patients (38 females, 12 males, age 13–81 years) with pHPT and negative localisation procedures such as ultrasound and sestamibi, a Met-PET/CT was performed before parathyroid surgery. The results of Met-PET/CT were analysed prospectively and compared with intraoperative and histopathological findings. 22% of the patients underwent previous parathyroid and/or thyroid surgery.

Results

Met-PET/CT correctly located a single-gland adenoma in 33 of 45 (73%) patients with pHPT. In 5 patients with multiglandular disease, Met-PET/CT detected at least one hyperfunctional parathyroid gland in 4 patients (80%). In 3 patients with double adenomas, 5 of 6 parathyroids were correctly located. Overall, 40 of 57 (70%) hyperfunctioning glands were identified with Met-PET/CT. Met-PET/CT was false-negative in 12 of 50 (24%) patients and false-positive in only one case (2%). Postoperatively, 48 of 50 patients (96%) were cured.

Conclusions

Additional pre-interventional imaging with Met-PET/CT was able to identify hyperfunctioning parathyroid glands in 74% of patients with pHPT and negative sestamibi scans, thus enabling successful parathyroid surgery.

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Title: Is C-11 Methionine PET/CT Able to Localise Sestamibi-Negative Parathyroid Adenomas?
Authors: Theresia Weber
Martin Gottstein
Sabrina Schwenzer
Ambros Beer
Markus Luster
Publication date: 01-04-2017
Publisher: Springer International Publishing
Published in: World Journal of Surgery / Issue 4/2017
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-016-3795-4

ACC 2024 Congress

Springer Medicine

Is C-11 Methionine PET/CT Able to Localise Sestamibi-Negative Parathyroid Adenomas?

Abstract

Background

Methods

Results

Conclusions

ACC 2024 Congress

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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