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Published in: World Journal of Surgery 5/2015

01-05-2015 | Original Scientific Report

Safety and Feasibility of Laparoscopic Hepatectomy for Hepatocellular Carcinoma in the Posterosuperior Liver Segments

Authors: Lunjian Xiang, Le Xiao, Jianwei Li, Jian Chen, Yudong Fan, Shuguo Zheng

Published in: World Journal of Surgery | Issue 5/2015

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Abstract

Background

Laparoscopic hepatectomy (LH) is mostly performed to treat solitary tumors in the anterolateral liver segments (II, III, IVb, V, and VI). Few reports are available on LH for the treatment of hepatocellular carcinoma (HCC) in the posterosuperior liver segments (I, IVa, VII, and VIII), especially in association with cirrhosis. The purpose of this study was to investigate the safety and feasibility of LH in this clinical setting.

Methods

From January 2008 to January 2011, LH was conducted in 56 patients with HCC in the posterosuperior liver segments (PS group) and 70 patients with HCC in the anterolateral liver segments (AL group) who were admitted to Southwest Hospital of the Third Military Medical University, Chongqing, China. The clinical data and follow-up results in the two groups of patients were retrospectively analyzed.

Results

No patient in either group died during the perioperative period. Statistically significant differences were found between the PS and AL groups in terms of the operation time (217.5 ± 63.7 vs 176.8 ± 48.4 min, P = 0.000), volume of blood loss (295.5 ± 186.8 vs 220.4 ± 164.2 ml, P = 0.001), conversion rate from laparoscopy to laparotomy (17.9 vs 7.1 %, P = 0.031), transfusion rate (16.1 vs 4.3 %, P = 0.025), cases of hepatic inflow occlusion (38/18 vs 28/42, P = 0.002), and duration of inflow occlusion (41.3 ± 16.3 vs 31.3 ± 12.2 min, P = 0.005). Parameters with no significant differences between the two groups of patients included tumor size (4.0 ± 1.5 vs 3.9 ± 1.7 cm, P = 0.894), resection margin (1.7 ± 0.7 vs 1.8 ± 0.6 cm, P = 0.102), postoperative complication rate (16.1 vs 17.1 %, P = 0.873), postoperative anal exhaust time (3.2 ± 0.6 vs 3.0 ± 0.6 days, P = 0.361), and postoperative hospital stay (10.5 ± 2.7 vs 10.0 ± 0.6 days, P = 0.102). The serum alanine transaminase (ALT) and aspartate aminotransferase (AST) levels on postoperative days 1 and 3 were significantly higher in the PS group than in the AL group. There were no significant differences in the postoperative levels of the serum total bilirubin, albumin, ALT, or AST levels on postoperative days 5 and 7. After 2–48 months of follow-up, no significant differences in the 1- and 3-year overall survival rates (92.9 vs 95.7 %, P = 0.487 and 76.0 vs 76.8 %, P = 0.878, respectively) or 1- and 3-year disease-free survival rates (85.7 vs 87.1 %, P = 0.797 and 57.6 vs 56.4 %, P = 0.806, respectively) were noted between the two groups.

Conclusions

LH is safe and feasible for selected patients with HCC in the posterosuperior segments of the liver.
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Metadata
Title
Safety and Feasibility of Laparoscopic Hepatectomy for Hepatocellular Carcinoma in the Posterosuperior Liver Segments
Authors
Lunjian Xiang
Le Xiao
Jianwei Li
Jian Chen
Yudong Fan
Shuguo Zheng
Publication date
01-05-2015
Publisher
Springer International Publishing
Published in
World Journal of Surgery / Issue 5/2015
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI
https://doi.org/10.1007/s00268-015-2946-3

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