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01-05-2015 | Original Scientific Report

Predicting Early Intrahepatic Recurrence After Curative Resection of Colorectal Liver Metastases with Molecular Markers

Authors: Masato Narita, Elie Oussoultzoglou, Marie-Pierre Chenard, Pascal Fuchshuber, Tetsuro Yamamoto, Pietro Addeo, Daniel Jaeck, Philippe Bachellier

Published in: World Journal of Surgery | Issue 5/2015

Abstract

Background

The aim of this case–control study was to identify clinicopathological factors and test three relevant biomarkers for their ability to predict early intrahepatic recurrence after curative liver resection for colorectal liver metastases (CLM).

Methods

Of the 184 patients with CLM undergoing hepatectomy between January 2007 and December 2009, thirty patients had intrahepatic disease recurrence within 6 months. The control group was randomly selected from a cohort of patients between April 1997 and December 2005 who have survived without disease recurrence after CLM resection for over 5 years. Both groups were matched for size of metastasis greater than 5.0 cm, the presence of multiple metastases, and synchronous versus metachronous CLM. The final study population consisted of 60 patients with CLM undergoing R0 hepatectomy, 30 of whom had early intrahepatic-only recurrences (study group) and 30 patients without recurrence for more than 5 years (control group). Both groups were analyzed and compared for the presence of clinical factors and expression levels of CD133, survivin, and Bcl-2 within tumor tissue.

Results

Characteristics of patients were similar between the two groups except primary tumor location and administration of postoperative chemotherapy. Expression level of CD133 and survivin were significantly increased in tumors of patients with recurrence compared to patients without recurrence. On multivariate analysis high tumor expression levels of CD133 (odds ratio [OR] 14.7, confidence interval [CI] 1.8–121.3, p = 0.012) and survivin (OR 9.5, CI 2.1–44.3, p = 0.004) and postoperative chemotherapy (OR 4.8, CI 1.01–22.9, p = 0.049) were independent factors associated with early intrahepatic recurrence.

Conclusions

Tumor expression levels of CD133 and survivin may be a useful predictor of early intrahepatic recurrence after hepatectomy for CLM. Administration of postoperative chemotherapy may prevent early intrahepatic recurrence.

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Title: Predicting Early Intrahepatic Recurrence After Curative Resection of Colorectal Liver Metastases with Molecular Markers
Authors: Masato Narita
Elie Oussoultzoglou
Marie-Pierre Chenard
Pascal Fuchshuber
Tetsuro Yamamoto
Pietro Addeo
Daniel Jaeck
Philippe Bachellier
Publication date: 01-05-2015
Publisher: Springer International Publishing
Published in: World Journal of Surgery / Issue 5/2015
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-014-2916-1

At a glance: The STEP trials

Springer Medicine

Predicting Early Intrahepatic Recurrence After Curative Resection of Colorectal Liver Metastases with Molecular Markers

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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