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World Journal of Surgery
Published in: World Journal of Surgery 3/2015

01-03-2015 | Scientific Review

Effect of Lipid-Modifying Therapy on Long-Term Mortality After Abdominal Aortic Aneurysm Repair: A Systemic Review and Meta-Analysis

Authors: Wenwen Zhang, Zhao Liu, Changjian Liu

Published in: World Journal of Surgery | Issue 3/2015

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Abstract

Background

Several observational studies have demonstrated that lipid-modifying therapy may improve long-term survival in abdominal aortic aneurysm (AAA) patients after repair. We carried out a systematic review and meta-analysis of studies evaluating the effect of lipid-modifying therapy on long-term mortality.

Patients and methods

We conducted a systematic search of multiple databases up to April 2014. Studies that evaluated exposure to lipid-modifying therapy, reported mortality data and hazard ratio (HR) or provided survival curve for their estimation were included in the meta-analysis. Pooled HR estimates with 95 % confidence intervals (CIs) were calculated using the random-effects model.

Results

Eight studies (seven cohorts, one post hoc study of a randomization controlled trial) reporting 2,605 patients on lipid-modifying therapy were included. Meta-analysis showed a significant 39 % reduction in long-term mortality with lipid-modifying therapy (HR 0.61; 95 % CI 0.51–0.73). After exclusion of one study which was contributing to considerable heterogeneity, a significant 33 % reduction in mortality risk was a more conservative, consistent estimate (HR 0.67; 95 % CI 0.59–0.77).

Conclusion

Meta-analysis of studies supports a protective role of lipid-modifying therapy on mortality risk after AAA repair. Aggressive lipid intervention should be recommended to those who receiving AAA repair.
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Metadata
Title
Effect of Lipid-Modifying Therapy on Long-Term Mortality After Abdominal Aortic Aneurysm Repair: A Systemic Review and Meta-Analysis
Authors
Wenwen Zhang
Zhao Liu
Changjian Liu
Publication date
01-03-2015
Publisher
Springer US
Published in
World Journal of Surgery / Issue 3/2015
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI
https://doi.org/10.1007/s00268-014-2858-7

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