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01-01-2015 | Scientific Review

Incidence of Venous Thromboembolism and Its Pharmacological Prophylaxis in Asian General Surgery Patients: A Systematic Review

Authors: Danson X. W. Yeo, Sameer Junnarkar, Sunder Balasubramaniam, Yen Pin Tan, Jee Keem Low, Winston Woon, Tony Chun Yeung Pang

Published in: World Journal of Surgery | Issue 1/2015

Abstract

Background

Venous thromboembolism (VTE) is a condition that has always been perceived to be rare in Asia. The aim of this systematic review was to gather the current available evidence on the incidence of VTE in this population. A secondary aim was to assess the efficacy of pharmacological prophylaxis, and hence determine its role, in the Asian population.

Methods

A comprehensive literature search was performed using MEDLINE, Embase, and the Cochrane Database of Systematic Reviews in June 2014. Articles found using search terms related to venous thromboembolism (VTE), Asian countries and general surgery procedures and pathologies were screened using the following inclusion criteria: (1) either the population studied was primarily Asian or the study was conducted in an Asian country, (2) the subjects studied underwent a major gastrointestinal or other general surgery procedure, (3) the primary outcome was the incidence of deep vein thrombosis (DVT) or pulmonary embolus (PE), and (4) secondary outcomes assessed included mortality and complications due to the VTE or prophylaxis against VTE.

Results

Fourteen publications with a total of 11,218 patients were analyzed. Nine of the fourteen were observational studies, with half being prospective in nature. There were five interventional studies of which two were randomized controlled trials. Among the observational studies, the median (range) incidence of above-knee DVT was 0.08 % (0–2.9 %), while the median (range) incidence of PE was 0.18 % (0–0.58 %). The rates of DVT in the control groups were reported to be between 0 and 7.4 %, while the incidence of PE in the control groups ranged from 0 to 1.9 %. Analysis of the comparative studies revealed that the incidence of bleeding-related complications varied from 0 to 18.1 % in the low-molecular-weight heparin (LMWH) group compared to 0–7.5 % in the control group. The difference in minor bleeding complications between the LMWH group and the control group was found to be statistically significant.

Conclusion

Data from this systematic review suggest that the risk of VTE in Asian general surgery patients is low, even in the context of risk factors typically regarded as high risk.

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Title: Incidence of Venous Thromboembolism and Its Pharmacological Prophylaxis in Asian General Surgery Patients: A Systematic Review
Authors: Danson X. W. Yeo
Sameer Junnarkar
Sunder Balasubramaniam
Yen Pin Tan
Jee Keem Low
Winston Woon
Tony Chun Yeung Pang
Publication date: 01-01-2015
Publisher: Springer US
Published in: World Journal of Surgery / Issue 1/2015
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-014-2763-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Incidence of Venous Thromboembolism and Its Pharmacological Prophylaxis in Asian General Surgery Patients: A Systematic Review

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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