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Published in: World Journal of Surgery 12/2013

01-12-2013

Value of Scintigraphy for Assessing Delayed Gastric Emptying After Pancreatic Surgery

Authors: Gan van Samkar, Wietse J. Eshuis, Marike Lemmers, Dirk J. Gouma, Roel J. Bennink, Markus W. Hollmann, Marcel G. W. Dijkgraaf, Olivier R. C. Busch

Published in: World Journal of Surgery | Issue 12/2013

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Abstract

Background

Delayed gastric emptying (DGE) occurs frequently after pancreatic surgery. Recently a consensus definition of DGE was introduced, and this grading system is currently widely used. The aim of this study was to compare results of gastric emptying scintigraphy with the grade of DGE after pancreatic surgery.

Methods

In 44 patients undergoing exploration for a pancreatic head or periampullary tumor, 28 pancreatoduodenectomies (PDs) and 16 double-bypass procedures were performed. All patients underwent preoperative and postoperative gastric emptying scintigraphy. We investigated whether the incidence of DGE was correlated with the results of gastric emptying scintigraphy.

Results

DGE occurred in 19 (43 %) patients. Clinically relevant DGE (grades B and C) prevailed in the PD group. Median postoperative residual activity at t = 2 h (%RA120) in these groups was 36 % (no DGE), 75 % (grade A), 93 % (grade B), and 95 % (grade C). DGE grade B or C was found in 7 of 10 patients with %RA120 of ≥94 % on postoperative day (POD) 7.

Conclusions

Postoperative %RA120 on scintigraphy is positively associated with severity of DGE. Gastric emptying scintigraphy on POD 7 can predict the severity of DGE. When postoperative gastric emptying scintigraphy shows high residual radioactivity, the likelihood of further progression to grade B or C DGE is high and warrants investigation for underlying causes.
Literature
1.
go back to reference Lytras D, Paraskevas KI, Avgerinos C et al (2007) Therapeutic strategies for the management of delayed gastric emptying after pancreatic resection. Langenbecks Arch Surg 392:1–12PubMedCrossRef Lytras D, Paraskevas KI, Avgerinos C et al (2007) Therapeutic strategies for the management of delayed gastric emptying after pancreatic resection. Langenbecks Arch Surg 392:1–12PubMedCrossRef
2.
go back to reference Izbicki JR, Bloechle C, Broering DC et al (1998) Extended drainage versus resection in surgery for chronic pancreatitis: a prospective randomized trial comparing the longitudinal pancreaticojejunostomy combined with local pancreatic head excision with the pylorus-preserving pancreatoduodenectomy. Ann Surg 228:771–779PubMedCrossRef Izbicki JR, Bloechle C, Broering DC et al (1998) Extended drainage versus resection in surgery for chronic pancreatitis: a prospective randomized trial comparing the longitudinal pancreaticojejunostomy combined with local pancreatic head excision with the pylorus-preserving pancreatoduodenectomy. Ann Surg 228:771–779PubMedCrossRef
3.
go back to reference Miedema BW, Sarr MG, van Heerden JA et al (1992) Complications following pancreaticoduodenectomy: current management. Arch Surg 127:945–949PubMedCrossRef Miedema BW, Sarr MG, van Heerden JA et al (1992) Complications following pancreaticoduodenectomy: current management. Arch Surg 127:945–949PubMedCrossRef
4.
5.
go back to reference Yeo CJ, Cameron JL, Sohn TA et al (1997) Six hundred fifty consecutive pancreaticoduodenectomies in the 1990s: pathology, complications, and outcomes. Ann Surg 226:248–257PubMedCrossRef Yeo CJ, Cameron JL, Sohn TA et al (1997) Six hundred fifty consecutive pancreaticoduodenectomies in the 1990s: pathology, complications, and outcomes. Ann Surg 226:248–257PubMedCrossRef
6.
go back to reference Lesurtel M, Dehni N, Tiret E et al (2006) Palliative surgery for unresectable pancreatic and periampullary cancer: a reappraisal. J Gastrointest Surg 10:286–291PubMedCrossRef Lesurtel M, Dehni N, Tiret E et al (2006) Palliative surgery for unresectable pancreatic and periampullary cancer: a reappraisal. J Gastrointest Surg 10:286–291PubMedCrossRef
7.
go back to reference Sohn TA, Lillemoe KD, Cameron JL et al (1999) Surgical palliation of unresectable periampullary adenocarcinoma in the 1990s. J Am Coll Surg 188:658–666PubMedCrossRef Sohn TA, Lillemoe KD, Cameron JL et al (1999) Surgical palliation of unresectable periampullary adenocarcinoma in the 1990s. J Am Coll Surg 188:658–666PubMedCrossRef
8.
go back to reference Riediger H, Makowiec F, Schareck WD et al (2003) Delayed gastric emptying after pylorus-preserving pancreatoduodenectomy is strongly related to other postoperative complications. J Gastrointest Surg 7:758–765PubMedCrossRef Riediger H, Makowiec F, Schareck WD et al (2003) Delayed gastric emptying after pylorus-preserving pancreatoduodenectomy is strongly related to other postoperative complications. J Gastrointest Surg 7:758–765PubMedCrossRef
9.
go back to reference Buchler MW, Wagner M, Schmied BM et al (2003) Changes in morbidity after pancreatic resection: toward the end of completion pancreatectomy. Arch Surg 138:1310–1314PubMedCrossRef Buchler MW, Wagner M, Schmied BM et al (2003) Changes in morbidity after pancreatic resection: toward the end of completion pancreatectomy. Arch Surg 138:1310–1314PubMedCrossRef
10.
go back to reference Fabre JM, Burgel JS, Navarro F et al (1999) Delayed gastric emptying after pancreaticoduodenectomy and pancreaticogastrostomy. Eur J Surg 165:560–565PubMedCrossRef Fabre JM, Burgel JS, Navarro F et al (1999) Delayed gastric emptying after pancreaticoduodenectomy and pancreaticogastrostomy. Eur J Surg 165:560–565PubMedCrossRef
11.
go back to reference Van Berge Henegouwen MI, van Gulik TM, DeWit LT et al (1997) Delayed gastric emptying after standard pancreaticoduodenectomy versus pylorus-preserving pancreaticoduodenectomy: an analysis of 200 consecutive patients. J Am Coll Surg 185:373–379PubMedCrossRef Van Berge Henegouwen MI, van Gulik TM, DeWit LT et al (1997) Delayed gastric emptying after standard pancreaticoduodenectomy versus pylorus-preserving pancreaticoduodenectomy: an analysis of 200 consecutive patients. J Am Coll Surg 185:373–379PubMedCrossRef
12.
go back to reference Yeo CJ, Barry MK, Sauter PK et al (1993) Erythromycin accelerates gastric emptying after pancreaticoduodenectomy: a prospective, randomized, placebo-controlled trial. Ann Surg 218:229–237PubMedCrossRef Yeo CJ, Barry MK, Sauter PK et al (1993) Erythromycin accelerates gastric emptying after pancreaticoduodenectomy: a prospective, randomized, placebo-controlled trial. Ann Surg 218:229–237PubMedCrossRef
13.
go back to reference Wente MN, Bassi C, Dervenis C et al (2007) Delayed gastric emptying (DGE) after pancreatic surgery: a suggested definition by the International Study Group of Pancreatic Surgery (ISGPS). Surgery 142:761–768PubMedCrossRef Wente MN, Bassi C, Dervenis C et al (2007) Delayed gastric emptying (DGE) after pancreatic surgery: a suggested definition by the International Study Group of Pancreatic Surgery (ISGPS). Surgery 142:761–768PubMedCrossRef
14.
go back to reference Welsch T, Borm M, Degrate L et al (2010) Evaluation of the International Study Group of Pancreatic Surgery definition of delayed gastric emptying after pancreatoduodenectomy in a high-volume centre. Br J Surg 97:1043–1050PubMedCrossRef Welsch T, Borm M, Degrate L et al (2010) Evaluation of the International Study Group of Pancreatic Surgery definition of delayed gastric emptying after pancreatoduodenectomy in a high-volume centre. Br J Surg 97:1043–1050PubMedCrossRef
15.
go back to reference Reber HA (2007) Delayed gastric emptying: what should be required for diagnosis? Surgery 142:769–770PubMedCrossRef Reber HA (2007) Delayed gastric emptying: what should be required for diagnosis? Surgery 142:769–770PubMedCrossRef
16.
go back to reference Abell TL, Camilleri M, Donohoe K et al (2008) Consensus recommendations for gastric emptying scintigraphy: a joint report of the American Neurogastroenterology and Motility Society and the Society of Nuclear Medicine. J Nucl Med Technol 36:44–54PubMedCrossRef Abell TL, Camilleri M, Donohoe K et al (2008) Consensus recommendations for gastric emptying scintigraphy: a joint report of the American Neurogastroenterology and Motility Society and the Society of Nuclear Medicine. J Nucl Med Technol 36:44–54PubMedCrossRef
17.
go back to reference Szarka LA, Camilleri M (2009) Methods for measurement of gastric motility. Am J Physiol Gastrointest Liver Physiol 296:G461–G475PubMedCrossRef Szarka LA, Camilleri M (2009) Methods for measurement of gastric motility. Am J Physiol Gastrointest Liver Physiol 296:G461–G475PubMedCrossRef
18.
go back to reference Braden B, Lembcke B, Kuker W et al (2007) 13C-breath tests: current state of the art and future directions. Dig Liver Dis 39:795–805PubMedCrossRef Braden B, Lembcke B, Kuker W et al (2007) 13C-breath tests: current state of the art and future directions. Dig Liver Dis 39:795–805PubMedCrossRef
19.
go back to reference Rao SS, Camilleri M, Hasler WL et al (2011) Evaluation of gastrointestinal transit in clinical practice: position paper of the American and European Neurogastroenterology and Motility Societies. Neurogastroenterol Motil 23:8–23PubMedCrossRef Rao SS, Camilleri M, Hasler WL et al (2011) Evaluation of gastrointestinal transit in clinical practice: position paper of the American and European Neurogastroenterology and Motility Societies. Neurogastroenterol Motil 23:8–23PubMedCrossRef
20.
go back to reference Molinari E, Bassi C, Salvia R et al (2007) Amylase value in drains after pancreatic resection as predictive factor of postoperative pancreatic fistula: results of a prospective study in 137 patients. Ann Surg 246:281–287PubMedCrossRef Molinari E, Bassi C, Salvia R et al (2007) Amylase value in drains after pancreatic resection as predictive factor of postoperative pancreatic fistula: results of a prospective study in 137 patients. Ann Surg 246:281–287PubMedCrossRef
22.
go back to reference Jones KL, Russo A, Stevens JE et al (2001) Predictors of delayed gastric emptying in diabetes. Diabetes Care 24:1264–1269PubMedCrossRef Jones KL, Russo A, Stevens JE et al (2001) Predictors of delayed gastric emptying in diabetes. Diabetes Care 24:1264–1269PubMedCrossRef
23.
go back to reference Samsom M, Vermeijden JR, Smout AJ et al (2003) Prevalence of delayed gastric emptying in diabetic patients and relationship to dyspeptic symptoms: a prospective study in unselected diabetic patients. Diabetes Care 26:3116–3122PubMedCrossRef Samsom M, Vermeijden JR, Smout AJ et al (2003) Prevalence of delayed gastric emptying in diabetic patients and relationship to dyspeptic symptoms: a prospective study in unselected diabetic patients. Diabetes Care 26:3116–3122PubMedCrossRef
24.
go back to reference Stevens JE, Jones KL, Rayner CK et al (2013) Pathophysiology and pharmacotherapy of gastroparesis: current and future perspectives. Expert Opin Pharmacother 14:1171–1186PubMedCrossRef Stevens JE, Jones KL, Rayner CK et al (2013) Pathophysiology and pharmacotherapy of gastroparesis: current and future perspectives. Expert Opin Pharmacother 14:1171–1186PubMedCrossRef
25.
go back to reference Nguyen NQ, Bryant LK, Burgstad CM et al (2013) Gastric emptying measurement of liquid nutrients using the C-octanoate breath test in critically ill patients: a comparison with scintigraphy. Intensive Care Med 39:1238–1246PubMedCrossRef Nguyen NQ, Bryant LK, Burgstad CM et al (2013) Gastric emptying measurement of liquid nutrients using the C-octanoate breath test in critically ill patients: a comparison with scintigraphy. Intensive Care Med 39:1238–1246PubMedCrossRef
26.
go back to reference Eshuis WJ, Hermanides J, van Dalen JW et al (2011) Early postoperative hyperglycemia is associated with postoperative complications after pancreatoduodenectomy. Ann Surg 253:739–744PubMedCrossRef Eshuis WJ, Hermanides J, van Dalen JW et al (2011) Early postoperative hyperglycemia is associated with postoperative complications after pancreatoduodenectomy. Ann Surg 253:739–744PubMedCrossRef
27.
go back to reference Van Heek NT, De Castro SM, van Eijck CH et al (2003) The need for a prophylactic gastrojejunostomy for unresectable periampullary cancer: a prospective randomized multicenter trial with special focus on assessment of quality of life. Ann Surg 238:894–902PubMedCrossRef Van Heek NT, De Castro SM, van Eijck CH et al (2003) The need for a prophylactic gastrojejunostomy for unresectable periampullary cancer: a prospective randomized multicenter trial with special focus on assessment of quality of life. Ann Surg 238:894–902PubMedCrossRef
28.
go back to reference Chijiiwa K, Imamura N, Ohuchida J et al (2009) Prospective randomized controlled study of gastric emptying assessed by (13)C-acetate breath test after pylorus-preserving pancreaticoduodenectomy: comparison between antecolic and vertical retrocolic duodenojejunostomy. J Hepatobiliary Pancreat Surg 16:49–55PubMedCrossRef Chijiiwa K, Imamura N, Ohuchida J et al (2009) Prospective randomized controlled study of gastric emptying assessed by (13)C-acetate breath test after pylorus-preserving pancreaticoduodenectomy: comparison between antecolic and vertical retrocolic duodenojejunostomy. J Hepatobiliary Pancreat Surg 16:49–55PubMedCrossRef
29.
go back to reference Hiyoshi M, Chijiiwa K, Ohuchida J et al (2012) Comparative study of gastric emptying and nutritional status after pylorus-preserving vs. subtotal stomach-preserving pancreaticoduodenectomy. Hepatogastroenterology 59:1018–1022PubMed Hiyoshi M, Chijiiwa K, Ohuchida J et al (2012) Comparative study of gastric emptying and nutritional status after pylorus-preserving vs. subtotal stomach-preserving pancreaticoduodenectomy. Hepatogastroenterology 59:1018–1022PubMed
30.
go back to reference Kawai M, Tani M, Hirono S et al (2011) Pylorus ring resection reduces delayed gastric emptying in patients undergoing pancreatoduodenectomy: a prospective, randomized, controlled trial of pylorus-resecting versus pylorus-preserving pancreatoduodenectomy. Ann Surg 253:495–501PubMedCrossRef Kawai M, Tani M, Hirono S et al (2011) Pylorus ring resection reduces delayed gastric emptying in patients undergoing pancreatoduodenectomy: a prospective, randomized, controlled trial of pylorus-resecting versus pylorus-preserving pancreatoduodenectomy. Ann Surg 253:495–501PubMedCrossRef
31.
Metadata
Title
Value of Scintigraphy for Assessing Delayed Gastric Emptying After Pancreatic Surgery
Authors
Gan van Samkar
Wietse J. Eshuis
Marike Lemmers
Dirk J. Gouma
Roel J. Bennink
Markus W. Hollmann
Marcel G. W. Dijkgraaf
Olivier R. C. Busch
Publication date
01-12-2013
Publisher
Springer US
Published in
World Journal of Surgery / Issue 12/2013
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI
https://doi.org/10.1007/s00268-013-2219-y

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