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01-06-2013

Incidence and Treatment of Local Site Recurrences Following RFA of Colorectal Liver Metastases

Authors: Karin Nielsen, Aukje A. J. M. van Tilborg, Martijn R. Meijerink, Matessa O. Macintosh, Babs M. Zonderhuis, Elly S. M. de Lange, Emile F. I. Comans, Sybren Meijer, M. Petrousjka van den Tol

Published in: World Journal of Surgery | Issue 6/2013

Abstract

Background

Patients with colorectal liver metastases (CRLM) who are ineligible for curative surgery are potential candidates for radiofrequency ablation (RFA). Although RFA has emerged as a well accepted and documented treatment modality, there are still some reservations because of initially high rates of local site recurrences (LSR). The aim of the present study was to evaluate LSR levels following RFA treatment, with a specific focus on re-treatment and survival.

Patients and methods

All patients ineligible for curative resection of CRLM and undergoing RFA alone or in combination with resection were prospectively included from July 2000 to December 2010 and retrospectively analyzed. Patients with untreatable extrahepatic disease were excluded. FDG PET–CT was conducted at 3–6 month intervals after RFA. Patients with LSR were evaluated for re-treatment.

Results

A total of 132 patients were treated with RFA, which was combined with resection in 64 patients. A total of 290 lesions were ablated, with a mean number of 2.19 per patient and a mean size of 2.2 cm. Median survival was 41 months, with a 3- and 5-year survival of, respectively, 60 and 30.8 %. Following initial RFA, 39 patients developed an LSR in 40 ablated lesions, and local recurrence was strongly related to lesion size. Re-treatment could be performed in 26/39 patients, of whom eight remained disease-free.

Conclusions

Radiofrequency ablation can be applied to CRLM of less than 3 cm with curative intent. In the absence of extensive intrahepatic or extrahepatic disease, renewed treatment of local recurrences should be considered and is often successful.

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Title: Incidence and Treatment of Local Site Recurrences Following RFA of Colorectal Liver Metastases
Authors: Karin Nielsen
Aukje A. J. M. van Tilborg
Martijn R. Meijerink
Matessa O. Macintosh
Babs M. Zonderhuis
Elly S. M. de Lange
Emile F. I. Comans
Sybren Meijer
M. Petrousjka van den Tol
Publication date: 01-06-2013
Publisher: Springer-Verlag
Published in: World Journal of Surgery / Issue 6/2013
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-013-1997-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Incidence and Treatment of Local Site Recurrences Following RFA of Colorectal Liver Metastases

Abstract

Background

Patients and methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Patients and methods

Results

Conclusions

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