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World Journal of Surgery

Published in:

01-12-2012

Risk Factor of Surgical Site Infection After Pancreaticoduodenectomy

Authors: Teiichi Sugiura, Katsuhiko Uesaka, Norio Ohmagari, Hideyuki Kanemoto, Takashi Mizuno

Published in: World Journal of Surgery | Issue 12/2012

Abstract

Background

Although surgical site infection (SSI) following pancreaticoduodenectomy is a common complication, the risk factors remain unclear.

Patients and methods

A retrospective study of 408 consecutive patients undergoing pancreaticoduodenectomy was conducted and the risk factors for SSI were assessed. The bacterial composition was also analyzed.

Results

Sixty-one patients developed incisional SSI, and 195 developed organ/space SSI. A multivariate analysis identified that length of operation >480 min (odds ratio [OR] 3.22), main pancreatic duct (MPD) ≤3 mm (OR 2.18), and abdominal wall thickness >10 mm (OR 2.16) were significant risk factors for incisional SSI. The development of pancreatic fistula (OR 7.56), use of semi-closed drainage system (OR 3.68), body mass index >23.5 kg/m² (OR 3.04), MPD ≤3 mm (OR 2.21), and length of operation >480 min (OR 1.78) were significantly associated with organ/space SSI. Bacterial isolation at the SSI foci revealed that gut-derived micro-organisms were the predominant bacterial species.

Conclusions

The presence of pancreatic fistula was the strongest risk factor for organ/space SSI. Efforts to reduce the development of pancreatic fistulas, to decrease length of operation, and to use a closed drainage system would decrease the incidence of SSI following pancreaticoduodenectomy. If SSI that requires antibacterial treatment occurs, then the treatment should target enterobacteria.

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Title: Risk Factor of Surgical Site Infection After Pancreaticoduodenectomy
Authors: Teiichi Sugiura
Katsuhiko Uesaka
Norio Ohmagari
Hideyuki Kanemoto
Takashi Mizuno
Publication date: 01-12-2012
Publisher: Springer-Verlag
Published in: World Journal of Surgery / Issue 12/2012
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-012-1742-6

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Risk Factor of Surgical Site Infection After Pancreaticoduodenectomy

Abstract

Background

Patients and methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Patients and methods

Results

Conclusions

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