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Published in:

01-09-2012

Microsatellite Instability Is Associated With a Better Prognosis for Gastric Cancer Patients After Curative Surgery

Authors: Wen-Liang Fang, Shih-Ching Chang, Yuan-Tzu Lan, Kuo-Hung Huang, Jen-Hao Chen, Su-Shun Lo, Mao-Chih Hsieh, Anna Fen-Yau Li, Chew-Wun Wu, Shih-Hwa Chiou

Published in: World Journal of Surgery | Issue 9/2012

Abstract

Background

Microsatellite instability (MSI) is one of the leading mechanisms for the carcinogenesis of gastric cancer. Its prognostic value is controversial.

Methods

Between May 1988 and Oct 2003, a total of 214 gastric cancer patients undergoing curative surgery were enrolled, and their MSI statuses were classified as MSI-H (high) or MSI-L/S (low/stable). The clinicopathologic characteristics of MSI-H and MSI-L/S gastric cancers were compared.

Results

The MSI-H tumors accounted for 11.7 % (n = 25) of the 214 total gastric cancers. Although not statistically significant, the MSI-H gastric cancers were more frequently located in the lower third of the stomach (64 % vs. 49.2 %) and were more often the intestinal type (72 % vs. 61.4 %) compared to the MSI-L/S gastric cancers. The MSI-H gastric cancers had a significantly better 5-year overall survival (OS) rate (68 % vs. 47.6 %, p = 0.030) and a trend of a better 3-year disease-free survival rate (71.8 % vs. 55.2 %, p = 0.076) compared to the MSI-L/S gastric cancers. A multivariate analysis revealed that pathologic TNM stage and MSI status were the independent prognostic factors for OS after curative surgery.

Conclusions

Compared to MSI-L/S tumors, MSI-H tumors are associated with a better OS rate for gastric cancer patients after R0 resection.

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Title: Microsatellite Instability Is Associated With a Better Prognosis for Gastric Cancer Patients After Curative Surgery
Authors: Wen-Liang Fang
Shih-Ching Chang
Yuan-Tzu Lan
Kuo-Hung Huang
Jen-Hao Chen
Su-Shun Lo
Mao-Chih Hsieh
Anna Fen-Yau Li
Chew-Wun Wu
Shih-Hwa Chiou
Publication date: 01-09-2012
Publisher: Springer-Verlag
Published in: World Journal of Surgery / Issue 9/2012
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-012-1652-7

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Microsatellite Instability Is Associated With a Better Prognosis for Gastric Cancer Patients After Curative Surgery

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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