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Published in: World Journal of Surgery 7/2012

01-07-2012

Robot-assisted Thoracoscopic Lymphadenectomy Along the Left Recurrent Laryngeal Nerve for Esophageal Squamous Cell Carcinoma in the Prone Position: Technical Report and Short-term Outcomes

Published in: World Journal of Surgery | Issue 7/2012

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Abstract

Background

Meticulous mediastinal lymphadenectomy frequently induces recurrent laryngeal nerve palsy (RLNP). Surgical robots with impressive dexterity and precise dissection skills have been developed to help surgeons perform operations. The objective of this study was to determine the impact on short-term outcomes of robot-assisted thoracoscopic radical esophagectomy performed on patients in the prone position for the treatment of esophageal squamous cell carcinoma, including its impact on RLNP.

Methods

A single-institution nonrandomized prospective study was performed. The patients (n = 36) with resectable esophageal squamous cell carcinoma were divided into two groups: patients who agreed to robot-assisted thoracoscopic esophagectomy with total mediastinal lymphadenectomy performed in the prone position (n = 16, robot-assisted group) without insurance reimbursement, and those who agreed to undergo the same operation without robot assistance but with health insurance coverage (n = 20, control group). These patients were observed for 30 days following surgery to assess short-term surgical outcomes, including the incidence of vocal cord palsy, hoarseness, and aspiration.

Results

Robot assistance significantly reduced the incidence of vocal cord palsy (p = 0.018) and hoarseness (p = 0.015) and the time on the ventilator (p = 0.025). There was no in-hospital mortality in either group. There were no significant differences between the two groups with respect to patient background, except for the use of preoperative therapy (robot-assisted group <control, p = 0.003). There were no significant differences in estimated blood loss, operating time, number of dissected lymph nodes, completeness of resection, or the incidence of the other complications, except for anastomotic leakage (p = 0.038).

Conclusion

Robot-assisted thoracoscopic esophagectomy with total mediastinal lymphadenectomy is feasible and safe. This method shows promise in preventing RLNP.
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Literature
1.
go back to reference Fujita H, Sueyoshi S, Tanaka T et al (2002) Three-field dissection for squamous cell carcinoma in the thoracic esophagus. Ann Thorac Cardiovasc Surg 8:328–335PubMed Fujita H, Sueyoshi S, Tanaka T et al (2002) Three-field dissection for squamous cell carcinoma in the thoracic esophagus. Ann Thorac Cardiovasc Surg 8:328–335PubMed
2.
go back to reference Bumm R, Wong J (1994) More or less surgery for esophageal cancer: extent of lymphadenectomy for squamous cell esophageal carcinoma - How much is necessary? Dis Esophagus 7:151–155 Bumm R, Wong J (1994) More or less surgery for esophageal cancer: extent of lymphadenectomy for squamous cell esophageal carcinoma - How much is necessary? Dis Esophagus 7:151–155
3.
go back to reference Fumagalli U, Panel of Experts (1996) Resective surgery for cancer of the thoracic esophagus: results of a Consensus Conference held at the 6th World Congress of the International Society for Diseases of the Esophagus. Dis Esophagus 9(suppl):30–38 Fumagalli U, Panel of Experts (1996) Resective surgery for cancer of the thoracic esophagus: results of a Consensus Conference held at the 6th World Congress of the International Society for Diseases of the Esophagus. Dis Esophagus 9(suppl):30–38
4.
go back to reference Gockel I, Kneist W, Keilmann A et al (2005) Recurrent laryngeal nerve paralysis (RLNP) following esophagectomy for carcinoma. Eur J Surg Oncol 31:277–281PubMedCrossRef Gockel I, Kneist W, Keilmann A et al (2005) Recurrent laryngeal nerve paralysis (RLNP) following esophagectomy for carcinoma. Eur J Surg Oncol 31:277–281PubMedCrossRef
6.
go back to reference Fujita H, Kakegawa T, Yamana H et al (1995) Mortality and morbidity rates, postoperative course, quality of life, and prognosis after extended radical lymphadenectomy for esophageal cancer. Comparison of three-field lymphadenectomy with two-field lymphadenectomy. Ann Surg 222:654–662PubMedCrossRef Fujita H, Kakegawa T, Yamana H et al (1995) Mortality and morbidity rates, postoperative course, quality of life, and prognosis after extended radical lymphadenectomy for esophageal cancer. Comparison of three-field lymphadenectomy with two-field lymphadenectomy. Ann Surg 222:654–662PubMedCrossRef
7.
go back to reference Peracchia A, Ruol A, Bardini R (1992) Lymph node dissection for cancer of the thoracic esophagus: how extended should it be? Analysis of personal data and review of the literature. Dis Esophagus 5:69–78 Peracchia A, Ruol A, Bardini R (1992) Lymph node dissection for cancer of the thoracic esophagus: how extended should it be? Analysis of personal data and review of the literature. Dis Esophagus 5:69–78
8.
go back to reference Baba M, Aikou T, Yoshinaka H et al (1994) Long-term results of subtotal esophagectomy with three-field lymphadenectomy for carcinoma of the thoracic esophagus. Ann Surg 219:310–316PubMedCrossRef Baba M, Aikou T, Yoshinaka H et al (1994) Long-term results of subtotal esophagectomy with three-field lymphadenectomy for carcinoma of the thoracic esophagus. Ann Surg 219:310–316PubMedCrossRef
9.
go back to reference Isono K, Sato H, Nakayama K (1991) Results of a nationwide study on the three-field lymph node dissection of esophageal cancer. Oncology 48:411–420PubMedCrossRef Isono K, Sato H, Nakayama K (1991) Results of a nationwide study on the three-field lymph node dissection of esophageal cancer. Oncology 48:411–420PubMedCrossRef
10.
go back to reference Nishimaki T, Suzuki T, Suzuki S et al (1998) Outcomes of extended radical esophagectomy for thoracic esophageal cancer. J Am Coll Surg 186:306–312PubMedCrossRef Nishimaki T, Suzuki T, Suzuki S et al (1998) Outcomes of extended radical esophagectomy for thoracic esophageal cancer. J Am Coll Surg 186:306–312PubMedCrossRef
11.
go back to reference Nishihira T, Mori S, Hirayama K (1992) Extensive lymph node dissection for thoracic esophageal carcinoma. Dis Esophagus 5:79–89 Nishihira T, Mori S, Hirayama K (1992) Extensive lymph node dissection for thoracic esophageal carcinoma. Dis Esophagus 5:79–89
12.
go back to reference Périé S, Laccourreye O, Bou-Malhab F et al (1998) Aspiration in unilateral recurrent laryngeal nerve paralysis after surgery. Am J Otolaryngol 19:18–23PubMedCrossRef Périé S, Laccourreye O, Bou-Malhab F et al (1998) Aspiration in unilateral recurrent laryngeal nerve paralysis after surgery. Am J Otolaryngol 19:18–23PubMedCrossRef
13.
go back to reference Noshiro H, Iwasaki H, Kobayashi K et al (2010) Lymphadenectomy along the left recurrent laryngeal nerve by a minimally invasive esophagectomy in the prone position for thoracic esophageal cancer. Surg Endosc 24:2965–2973PubMedCrossRef Noshiro H, Iwasaki H, Kobayashi K et al (2010) Lymphadenectomy along the left recurrent laryngeal nerve by a minimally invasive esophagectomy in the prone position for thoracic esophageal cancer. Surg Endosc 24:2965–2973PubMedCrossRef
14.
go back to reference Boone J, Schipper ME, Moojen WA et al (2009) Robot-assisted thoracoscopic oesophagectomy for cancer. Br J Surg 96:878–886PubMedCrossRef Boone J, Schipper ME, Moojen WA et al (2009) Robot-assisted thoracoscopic oesophagectomy for cancer. Br J Surg 96:878–886PubMedCrossRef
15.
go back to reference Ruurda JP, van Vroonhoven TJ, Broeders IA (2002) Robot-assisted surgical systems: a new era in laparoscopic surgery. Ann R Coll Surg Engl 84:223–226PubMedCrossRef Ruurda JP, van Vroonhoven TJ, Broeders IA (2002) Robot-assisted surgical systems: a new era in laparoscopic surgery. Ann R Coll Surg Engl 84:223–226PubMedCrossRef
16.
go back to reference Camarillo DB, Krummel TM, Salisbury JK Jr (2004) Robotic technology in surgery: past, present, and future. Am J Surg 188:2S–15SPubMedCrossRef Camarillo DB, Krummel TM, Salisbury JK Jr (2004) Robotic technology in surgery: past, present, and future. Am J Surg 188:2S–15SPubMedCrossRef
18.
go back to reference Oken MM, Creech RH, Tormey DC et al (1982) Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol 5:649–655PubMedCrossRef Oken MM, Creech RH, Tormey DC et al (1982) Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol 5:649–655PubMedCrossRef
19.
go back to reference Suda K, Kitagawa Y, Ozawa S et al (2007) Neutrophil elastase inhibitor improves postoperative clinical courses after thoracic esophagectomy. Dis Esophagus 20:478–486PubMedCrossRef Suda K, Kitagawa Y, Ozawa S et al (2007) Neutrophil elastase inhibitor improves postoperative clinical courses after thoracic esophagectomy. Dis Esophagus 20:478–486PubMedCrossRef
20.
go back to reference Rice TW, Blackstone EH, Rusch VW (2010) 7th edition of the AJCC Cancer Staging Manual: esophagus and esophagogastric junction. Ann Surg Oncol 17:1721–1724PubMedCrossRef Rice TW, Blackstone EH, Rusch VW (2010) 7th edition of the AJCC Cancer Staging Manual: esophagus and esophagogastric junction. Ann Surg Oncol 17:1721–1724PubMedCrossRef
21.
go back to reference Engstad K, Schipper PH (2009) Laryngopharyngeal dysfunction after esophagectomy. In: Jobe BA, Thomas CR, Hunter JG (eds) Esophageal cancer: principles and practice. Demos Medical Publishing, New York, pp 660–661 Engstad K, Schipper PH (2009) Laryngopharyngeal dysfunction after esophagectomy. In: Jobe BA, Thomas CR, Hunter JG (eds) Esophageal cancer: principles and practice. Demos Medical Publishing, New York, pp 660–661
22.
go back to reference Baba M, Aikou T, Natsugoe S et al (1998) Quality of life following esophagectomy with three-field lymphadenectomy for carcinoma, focusing on its relationship to vocal cord palsy. Dis Esophagus 11:28–34PubMed Baba M, Aikou T, Natsugoe S et al (1998) Quality of life following esophagectomy with three-field lymphadenectomy for carcinoma, focusing on its relationship to vocal cord palsy. Dis Esophagus 11:28–34PubMed
23.
go back to reference Akiyama H, Tsurumaru M, Udagawa H et al (1994) Radical lymph node dissection for cancer of the thoracic esophagus. Ann Surg 220:364–372PubMedCrossRef Akiyama H, Tsurumaru M, Udagawa H et al (1994) Radical lymph node dissection for cancer of the thoracic esophagus. Ann Surg 220:364–372PubMedCrossRef
24.
go back to reference Watanabe H, Kato H, Tachimori Y (2000) Significance of extended systemic lymph node dissection for thoracic esophageal carcinoma in Japan. Recent Results Cancer Res 155:123–133PubMedCrossRef Watanabe H, Kato H, Tachimori Y (2000) Significance of extended systemic lymph node dissection for thoracic esophageal carcinoma in Japan. Recent Results Cancer Res 155:123–133PubMedCrossRef
25.
go back to reference Shiozaki H, Yano M, Tsujinaka T et al (2001) Lymph node metastasis along the recurrent nerve chain is an indication for cervical lymph node dissection in thoracic esophageal cancer. Dis Esophagus 14:191–196PubMedCrossRef Shiozaki H, Yano M, Tsujinaka T et al (2001) Lymph node metastasis along the recurrent nerve chain is an indication for cervical lymph node dissection in thoracic esophageal cancer. Dis Esophagus 14:191–196PubMedCrossRef
26.
go back to reference Tsurumaru M, Kajiyama Y, Udagawa H et al (2001) Outcomes of extensive lymph node dissection for squamous cell carcinoma of the thoracic esophagus. Ann Thoracic Cardiovasc Surg 7:325–329 Tsurumaru M, Kajiyama Y, Udagawa H et al (2001) Outcomes of extensive lymph node dissection for squamous cell carcinoma of the thoracic esophagus. Ann Thoracic Cardiovasc Surg 7:325–329
27.
go back to reference Nishimaki T, Suzuki T, Tanaka Y et al (1997) Evaluating the rational extent of dissection in radical esophagectomy for invasive carcinoma of the thoracic esophagus. Surg Today 27:3–8PubMedCrossRef Nishimaki T, Suzuki T, Tanaka Y et al (1997) Evaluating the rational extent of dissection in radical esophagectomy for invasive carcinoma of the thoracic esophagus. Surg Today 27:3–8PubMedCrossRef
28.
go back to reference van Hillegersberg R, Boone J, Draaisma WA et al (2006) First experience with robot-assisted thoracoscopic esophagolymphadenectomy for esophageal cancer. Surg Endosc 20:1435–1439PubMedCrossRef van Hillegersberg R, Boone J, Draaisma WA et al (2006) First experience with robot-assisted thoracoscopic esophagolymphadenectomy for esophageal cancer. Surg Endosc 20:1435–1439PubMedCrossRef
29.
go back to reference Kernstine KH, DeArmond DT, Shamoun DM et al (2007) The first series of completely robotic esophagectomies with three-field lymphadenectomy: initial experience. Surg Endosc 21:2285–2292PubMedCrossRef Kernstine KH, DeArmond DT, Shamoun DM et al (2007) The first series of completely robotic esophagectomies with three-field lymphadenectomy: initial experience. Surg Endosc 21:2285–2292PubMedCrossRef
30.
go back to reference Kim DJ, Hyung WJ, Lee CY et al (2010) Thoracoscopic esophagectomy for esophageal cancer: feasibility and safety of robotic assistance in the prone position. J Thorac Cardiovasc Surg 139:53–59PubMedCrossRef Kim DJ, Hyung WJ, Lee CY et al (2010) Thoracoscopic esophagectomy for esophageal cancer: feasibility and safety of robotic assistance in the prone position. J Thorac Cardiovasc Surg 139:53–59PubMedCrossRef
Metadata
Title
Robot-assisted Thoracoscopic Lymphadenectomy Along the Left Recurrent Laryngeal Nerve for Esophageal Squamous Cell Carcinoma in the Prone Position: Technical Report and Short-term Outcomes
Publication date
01-07-2012
Published in
World Journal of Surgery / Issue 7/2012
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI
https://doi.org/10.1007/s00268-012-1538-8

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