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World Journal of Surgery
Published in: World Journal of Surgery 9/2011

01-09-2011

Changes in Metabolic Profile and Adipoinsular Axis in Morbidly Obese Premenopausal Females Treated with Restrictive Bariatric Surgery

Authors: Georgios Marantos, Markos Daskalakis, Nikolaos Karkavitsas, Ioannis Matalliotakis, John A. Papadakis, John Melissas

Published in: World Journal of Surgery | Issue 9/2011

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Abstract

Background

The aim of the present study was to evaluate the effects of surgically induced weight loss on the metabolic profile and adipocytokine levels in premenopausal morbidly obese females.

Methods

Twenty premenopausal morbidly obese (MO) women with a median age of 34 years (range: 24–48 years) and a median body mass index (BMI) of 41.47 kg/m2 (range: 38.0–56.73 kg/m2) were studied (13 women underwent gastric banding and 7 women underwent sleeve gastrectomy). In addition, 20 lean premenopausal women with a median age of 32 years (range: 22–44 years) and a median BMI of 20.0 kg/m2 (range: 18.5–24.7 kg/m2) were also studied. Anthropometric measurements and metabolic parameters were analyzed in each patient, along with changes in leptin, adiponectin, resistin, and interleukin-6 (IL-6) before surgery, 6 months after surgery, and 12 months after surgery. Comparisons with the reference normal-weight subjects were also performed.

Results

Both weight and BMI were found to be significantly decreased postoperatively. A 54.5% loss of excess BMI was observed 12 months after surgery, and was associated with significant improvement in all anthropometric and metabolic parameters. Twelve months after surgery we also observed decreased levels of serum leptin, resistin, and IL-6; increased levels of serum adiponectin; and a remarkable improvement in metabolic syndrome markers. Furthermore, postoperative serum resistin and IL-6 levels were found to reach those of normal-weight volunteers.

Conclusions

The results of this study suggest that weight loss through restrictive bariatric surgery results in a significant reduction in leptin, resistin, and IL-6 levels, and an increase in adiponectin levels, in addition to improving insulin sensitivity and glucose and lipid homeostasis in young morbidly obese female patients. These changes were significantly correlated with the magnitude of weight loss.
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Metadata
Title
Changes in Metabolic Profile and Adipoinsular Axis in Morbidly Obese Premenopausal Females Treated with Restrictive Bariatric Surgery
Authors
Georgios Marantos
Markos Daskalakis
Nikolaos Karkavitsas
Ioannis Matalliotakis
John A. Papadakis
John Melissas
Publication date
01-09-2011
Publisher
Springer-Verlag
Published in
World Journal of Surgery / Issue 9/2011
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI
https://doi.org/10.1007/s00268-011-1165-9

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