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World Journal of Surgery
Published in: World Journal of Surgery 2/2011

01-02-2011

Managing BRCA Mutation Carriers in China

Author: Kyriakos Kalogerakos

Published in: World Journal of Surgery | Issue 2/2011

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Excerpt

Inherited mutations in BRCA1 or BRCA2 (BRCA1/2) genes confer a high lifetime risk of ~75% for breast cancer development and ~20–60% for ovarian cancer in women who test positive for these mutations. In the United States and Europe genetic testing is widely used and can identify these high-risk women with BRCA1/2 mutation carriers who more often select prophylactic surgery rather than surveillance. However, data on family history, genetic testing, and preventive intervention in Asian countries such as China are scarce. …
Literature
1.
Kwong A, Wong CH, Shea C et al (2010) Choice of management of southern Chinese BRCA mutation carriers. World J Surg 34:1416–1426CrossRefPubMed
2.
Ziogas D, Roukos DH (2009) Genetics and personal genomics for personalized breast cancer surgery: progress and challenges in research and clinical practice. Ann Surg Oncol 16:1771–1782CrossRefPubMed
3.
Metcalfe KA, Lubinski J, Ghadirian P et al (2008) Predictors of contralateral prophylactic mastectomy in women with a BRCA1 or BRCA2 mutation: the Hereditary Breast Cancer Clinical Study Group. J Clin Oncol 26:1093–1097CrossRefPubMed
4.
Roukos DH (2009) Breast cancer outcomes: the crucial role of the breast surgeon in the era of personal genetics and systems biology. Ann Surg 249(6):1067–1068CrossRefPubMed
5.
Roukos DH, Ziogas D (2010) From tumor size and HER2 status to systems oncology for very early breast cancer treatment. Expert Rev Anticancer Ther 10(2):123–128CrossRefPubMed
6.
Roukos DH, Ziogas DE, Katsios C (2010) Multigene assays and isolated tumor cells for early breast cancer treatment: time for bionetworks. Expert Rev Anticancer Ther 10(8):1187–1195CrossRefPubMed
7.
Roukos DH (2010) Complete genome sequencing and network modeling to overcome trastuzumab resistance. Pharmacogenomics 11(8):1039–1043CrossRefPubMed
8.
Roukos DH (2010) Next-generation, genome sequencing-based biomarkers: concerns and challenges for medical practice. Biomark Med 4(4):583–586CrossRefPubMed
9.
Katsios C, Roukos DH (2010) Individual genomes and personalized medicine: life diversity and complexity. Per Med 7(4): 347–350CrossRef
10.
Roukos DH, Katsios C, Liakakos T (2010) Genotype-phenotype map and molecular networks: a promising solution in overcoming colorectal cancer resistance to targeted treatment. Expert Rev Mol Diagn 10(5):541–545CrossRefPubMed
11.
12.
Roukos DH (2010) Systems medicine: a real approach for future personalized oncology? Pharmacogenomics 11(3):283–287CrossRefPubMed
13.
Roukos DH (2010) Novel clinico-genome network modeling for revolutionizing genotype-phenotype-based personalized cancer care. Expert Rev Mol Diagn 10(1):33–48CrossRefPubMed
14.
Roukos DH (2009) Isolated tumor cells in breast cancer. N Engl J Med 361:1994–1995; author reply 1995–1996CrossRefPubMed
15.
Roukos DH, Tzakos A, Zografos G (2009) Current concerns and challenges towards tailored anti-angiogenic therapy in cancer. Expert Rev Anticancer Ther 9(10):1413–1416CrossRefPubMed
Metadata
Title
Managing BRCA Mutation Carriers in China
Author
Kyriakos Kalogerakos
Publication date
01-02-2011
Publisher
Springer-Verlag
Published in
World Journal of Surgery / Issue 2/2011
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI
https://doi.org/10.1007/s00268-010-0788-6

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