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Published in: World Journal of Surgery 10/2010

01-10-2010

Video-Assisted Bilateral Neck Exploration in Patients with Primary Hyperparathyroidism and Failed Localization Studies

Authors: Pier F. Alesina, Reyaz M. Singaporewalla, Martin K. Walz

Published in: World Journal of Surgery | Issue 10/2010

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Abstract

Background

In primary hyperparathyroidism (pHPT) positive preoperative localization studies are accepted as a precondition for applying minimally invasive surgical techniques. Without localization, open bilateral neck exploration (BNE) is considered the standard option. Thepresent study analyzes the feasibility and effectiveness of minimally invasive video-assisted BNE in patients with pHPT and negative or discordant localization studies.

Methods

From a prospective series of 380 minimally invasive video-assisted parathyroidectomies (MIVAP) performed in 367 patients for pHPT (1999–2009), 68 patients (10 male, 58 female; mean age: 58 years) were selected. These patients had failed localization studies and underwent BNE with the MIVAP technique. Operative time, complications, conversions to open technique, and cure rate were determined.

Results

Mean operative time was 52 ± 26 min (range: 20–180 min). MIVAP with BNE was successfully completed in 66 (97%) patients with two conversions to open technique. Recurrent laryngeal nerve palsy occurred in one patient. Biochemical cure was achieved in 67 patients (98.5%), in 65 patients (95.5%) after the first operation and in two more patients by video-assisted re-exploration on the first postoperative day. One patient remained with persistent disease even after repeated open BNE.

Conclusions

In experienced hands, video-assisted BNE with the MIVAP technique, for pHPT and failed localization studies, is feasible, safe, and gives results equivalent to the conventional open technique.
Literature
1.
go back to reference Mollerup CL, Bollerslev J, Blichert-Toft M (1994) Primary hyperparathyroidism: incidence and clinical and biochemical characteristics. A demographic study. Eur J Surg 160:485–489PubMed Mollerup CL, Bollerslev J, Blichert-Toft M (1994) Primary hyperparathyroidism: incidence and clinical and biochemical characteristics. A demographic study. Eur J Surg 160:485–489PubMed
2.
go back to reference Rubin MR, Bilezikian JP, McMahon DJ et al (2008) The natural history of primary of primary hyperparathyroidism with or without parathyroid surgery after 15 years. J Clin Endocrinol Metab 93:3462–3470CrossRefPubMed Rubin MR, Bilezikian JP, McMahon DJ et al (2008) The natural history of primary of primary hyperparathyroidism with or without parathyroid surgery after 15 years. J Clin Endocrinol Metab 93:3462–3470CrossRefPubMed
3.
go back to reference Mack LA, Pasieka J (2004) Asymptomatic primary hyperparathyroidism: a surgical perspective. Surg Clin North Am 84:803–816CrossRefPubMed Mack LA, Pasieka J (2004) Asymptomatic primary hyperparathyroidism: a surgical perspective. Surg Clin North Am 84:803–816CrossRefPubMed
4.
go back to reference Edwards ME, Rotramel A, Beyer T et al (2006) Improvement in the health-related quality-of-life symptoms of hyperparathyroidism is durable on long-term follow-up. Surgery 140:655–663CrossRefPubMed Edwards ME, Rotramel A, Beyer T et al (2006) Improvement in the health-related quality-of-life symptoms of hyperparathyroidism is durable on long-term follow-up. Surgery 140:655–663CrossRefPubMed
5.
go back to reference Walgenbach S, Hommel G, Junginger T (2000) Outcome after surgery for primary hyperparathyroidism: ten-year prospective follow-up study. World J Surg 24:564–569CrossRefPubMed Walgenbach S, Hommel G, Junginger T (2000) Outcome after surgery for primary hyperparathyroidism: ten-year prospective follow-up study. World J Surg 24:564–569CrossRefPubMed
6.
go back to reference Mandl F (1926) Therapeutisher versuch bein falls von ostitis fibrosa generalisata mittles. Extirpation eines epithelko¨rperchen tumors. Wien Klin Wochenschr 143:245–284 Mandl F (1926) Therapeutisher versuch bein falls von ostitis fibrosa generalisata mittles. Extirpation eines epithelko¨rperchen tumors. Wien Klin Wochenschr 143:245–284
7.
go back to reference van Heerden JA, Grant CS (1991) Surgical treatment of primary hyperparathyroidism: an institutional perspective. World J Surg 15:688–692CrossRefPubMed van Heerden JA, Grant CS (1991) Surgical treatment of primary hyperparathyroidism: an institutional perspective. World J Surg 15:688–692CrossRefPubMed
8.
go back to reference Lumachi F, Zucchetta P, Marzola MC et al (2000) Advantages of combined technetium-99 m-sestamibi scintigraphy and high-resolution ultrasonography in parathyroid localization: comparative study in 91 patients with primary hyperparathyroidism. Eur J Endocrinol 143:755–760CrossRefPubMed Lumachi F, Zucchetta P, Marzola MC et al (2000) Advantages of combined technetium-99 m-sestamibi scintigraphy and high-resolution ultrasonography in parathyroid localization: comparative study in 91 patients with primary hyperparathyroidism. Eur J Endocrinol 143:755–760CrossRefPubMed
9.
go back to reference Johnson NA, Tublin ME, Ogilvie JB (2007) Parathyroid imaging: technique and role in the preoperative evaluation of primary hyperparathyroidism. AJR Am J Roentgenol 188:1706–1715CrossRefPubMed Johnson NA, Tublin ME, Ogilvie JB (2007) Parathyroid imaging: technique and role in the preoperative evaluation of primary hyperparathyroidism. AJR Am J Roentgenol 188:1706–1715CrossRefPubMed
10.
go back to reference Irvin GL III, Dembrow VD, Prudhomme DL (1993) Clinical usefulness of an intraoperative “quick parathyroid hormone” assay. Surgery 114:1019–1023PubMed Irvin GL III, Dembrow VD, Prudhomme DL (1993) Clinical usefulness of an intraoperative “quick parathyroid hormone” assay. Surgery 114:1019–1023PubMed
11.
go back to reference Bergson EJ, Sznyter LA, Dubner S et al (2004) Sestamibi scans and intraoperative parathyroid hormone measurement in the treatment of primary hyperparathyroidism. Arch Otolaryngol Head Neck Surg 130:87–91CrossRefPubMed Bergson EJ, Sznyter LA, Dubner S et al (2004) Sestamibi scans and intraoperative parathyroid hormone measurement in the treatment of primary hyperparathyroidism. Arch Otolaryngol Head Neck Surg 130:87–91CrossRefPubMed
12.
go back to reference Lee JA, Inabnet WB III (2005) The surgeon’s armamenterium to surgical treatment of primary hyperparathyroidism. J Surg Oncol 89:130–135CrossRefPubMed Lee JA, Inabnet WB III (2005) The surgeon’s armamenterium to surgical treatment of primary hyperparathyroidism. J Surg Oncol 89:130–135CrossRefPubMed
13.
go back to reference Palazzo FF, Delbridge LW (2004) Minimal-access/minimally invasive parathyroidectomy for primary hyperparathyroidism. Surg Clin North Am 84:717–734CrossRefPubMed Palazzo FF, Delbridge LW (2004) Minimal-access/minimally invasive parathyroidectomy for primary hyperparathyroidism. Surg Clin North Am 84:717–734CrossRefPubMed
14.
go back to reference Miccoli P, Bendinelli C, Berti P et al (1999) Video-assisted versus conventional parathyroidectomy in primary hyperparathyroidism: a prospective randomized study. Surgery 126:1117–1121CrossRefPubMed Miccoli P, Bendinelli C, Berti P et al (1999) Video-assisted versus conventional parathyroidectomy in primary hyperparathyroidism: a prospective randomized study. Surgery 126:1117–1121CrossRefPubMed
15.
go back to reference Bergenfelz A, Lindlom P, Tibblin S et al (2002) Unilateral versus bilateral neck exploration for primary hyperparathyroidism: a prospective randomised controlled trial. Ann Surg 236:543–551CrossRefPubMed Bergenfelz A, Lindlom P, Tibblin S et al (2002) Unilateral versus bilateral neck exploration for primary hyperparathyroidism: a prospective randomised controlled trial. Ann Surg 236:543–551CrossRefPubMed
16.
go back to reference Russel CF, Dolan SJ, Laird JD (2006) Randomised clinical trial comparing scan-directed unilateral versus bilateral exploration for parathyroidectomy due to solitary adenoma. Br J Surg 93:418–421CrossRef Russel CF, Dolan SJ, Laird JD (2006) Randomised clinical trial comparing scan-directed unilateral versus bilateral exploration for parathyroidectomy due to solitary adenoma. Br J Surg 93:418–421CrossRef
17.
go back to reference Henry JF, Raffaelli M, Iacobone M et al (2001) Video-assisted parathyroidectomy via the lateral approach vs conventional surgery in the treatment of sporadic primary hyperparathyroidism: results of a case-control study. Surg Endosc 15:1116–1119CrossRefPubMed Henry JF, Raffaelli M, Iacobone M et al (2001) Video-assisted parathyroidectomy via the lateral approach vs conventional surgery in the treatment of sporadic primary hyperparathyroidism: results of a case-control study. Surg Endosc 15:1116–1119CrossRefPubMed
18.
go back to reference Tang T, Dolan S, Robinson B et al (2007) Does the surgical approach affect quality of life outcomes?—a comparison of minimally invasive parathyroidectomy with open parathyroidectomy. Int J Surg 5:17–22CrossRefPubMed Tang T, Dolan S, Robinson B et al (2007) Does the surgical approach affect quality of life outcomes?—a comparison of minimally invasive parathyroidectomy with open parathyroidectomy. Int J Surg 5:17–22CrossRefPubMed
19.
go back to reference Sackett WR, Barraclough B, Reeve TS et al (2002) Worldwide trends in the surgical treatment of primary hyperparathyroidism in the era of minimally invasive parathyroidectomy. Arch Surg 137:1055–1059CrossRefPubMed Sackett WR, Barraclough B, Reeve TS et al (2002) Worldwide trends in the surgical treatment of primary hyperparathyroidism in the era of minimally invasive parathyroidectomy. Arch Surg 137:1055–1059CrossRefPubMed
20.
go back to reference Arici C, Cheah WK, Ituarte PH et al (2001) Can localization studies be used to direct focused parathyroid operations? Surgery 129:720–729CrossRefPubMed Arici C, Cheah WK, Ituarte PH et al (2001) Can localization studies be used to direct focused parathyroid operations? Surgery 129:720–729CrossRefPubMed
21.
go back to reference Scheiner JD, Dupuy DE, Monchik JM et al (2001) Pre-operative localization of parathyroid adenomas: a comparison of power and colour Doppler ultrasonography with nuclear medicine scintigraphy. Clin Radiol 56:984–988CrossRefPubMed Scheiner JD, Dupuy DE, Monchik JM et al (2001) Pre-operative localization of parathyroid adenomas: a comparison of power and colour Doppler ultrasonography with nuclear medicine scintigraphy. Clin Radiol 56:984–988CrossRefPubMed
22.
go back to reference Moalem J, Guerrero M, Kebebew E (2009) Bilateral neck exploration in primary hyperparathyroidism—when is it selected and how is it performed. World J Surg 33:2282–2291CrossRefPubMed Moalem J, Guerrero M, Kebebew E (2009) Bilateral neck exploration in primary hyperparathyroidism—when is it selected and how is it performed. World J Surg 33:2282–2291CrossRefPubMed
23.
go back to reference Chen H, Pruhs Z, Starling JR et al (2005) Intraoperative parathyroid hormone testing improves cure rates in patients undergoing minimally invasive parathyroidectomy. Surgery 138:583–587CrossRefPubMed Chen H, Pruhs Z, Starling JR et al (2005) Intraoperative parathyroid hormone testing improves cure rates in patients undergoing minimally invasive parathyroidectomy. Surgery 138:583–587CrossRefPubMed
24.
go back to reference Miccoli P, Berti P, Materazzi G et al (2004) Results of video-assisted Parathyroidectomy: single institution’s six year experience. World J Surg 28:1216–1218CrossRefPubMed Miccoli P, Berti P, Materazzi G et al (2004) Results of video-assisted Parathyroidectomy: single institution’s six year experience. World J Surg 28:1216–1218CrossRefPubMed
25.
go back to reference Gawande AA, Monchik JM, Abbruzzese TA et al (2006) Reassessment of parathyroid hormone monitoring during parathyroidectomy for primary hyperparathyroidism after 2 preoperative localization studies. Arch Surg 141:381–384 discussion 384CrossRefPubMed Gawande AA, Monchik JM, Abbruzzese TA et al (2006) Reassessment of parathyroid hormone monitoring during parathyroidectomy for primary hyperparathyroidism after 2 preoperative localization studies. Arch Surg 141:381–384 discussion 384CrossRefPubMed
26.
go back to reference Mihai R, Palazzo FF, Gleeson FV et al (2007) Minimally invasive parathyroidectomy without intraoperative parathyroid hormone monitoring in patients with primary hyperparathyroidism. Br J Surg 94:42–47CrossRefPubMed Mihai R, Palazzo FF, Gleeson FV et al (2007) Minimally invasive parathyroidectomy without intraoperative parathyroid hormone monitoring in patients with primary hyperparathyroidism. Br J Surg 94:42–47CrossRefPubMed
27.
go back to reference Jacobson SR, van Heerden JA, Farley DR et al (2004) Focused cervical exploration for primary hyperparathyroidism without intraoperative parathyroid hormone monitoring or use of the gamma probe. World J Surg 28:1127–1131CrossRefPubMed Jacobson SR, van Heerden JA, Farley DR et al (2004) Focused cervical exploration for primary hyperparathyroidism without intraoperative parathyroid hormone monitoring or use of the gamma probe. World J Surg 28:1127–1131CrossRefPubMed
28.
go back to reference Gauger PG, Agarwal G, England BG et al (2001) Intraoperative parathyroid hormone monitoring fails to detect double parathyroid adenomas: a 2-institution experience. Surgery 130:1005–1010CrossRefPubMed Gauger PG, Agarwal G, England BG et al (2001) Intraoperative parathyroid hormone monitoring fails to detect double parathyroid adenomas: a 2-institution experience. Surgery 130:1005–1010CrossRefPubMed
29.
go back to reference Karakousis GC, Han D, Kelz RR et al (2007) Interpretation of intra-operative PTH changes in patients with multi-glandular primary hyperparathyroidism (pHPT). Surgery 142:845–850CrossRefPubMed Karakousis GC, Han D, Kelz RR et al (2007) Interpretation of intra-operative PTH changes in patients with multi-glandular primary hyperparathyroidism (pHPT). Surgery 142:845–850CrossRefPubMed
30.
go back to reference Phillips IJ, Kurzawinski TR, Honour JW (2005) Potential pitfalls in intraoperative parathyroid hormone measurements during parathyroid surgery. Ann Clin Biochem 42:453–458CrossRefPubMed Phillips IJ, Kurzawinski TR, Honour JW (2005) Potential pitfalls in intraoperative parathyroid hormone measurements during parathyroid surgery. Ann Clin Biochem 42:453–458CrossRefPubMed
31.
go back to reference Fraker DL, Harsono H, Lewis R (2009) Minimally invasive parathyroidectomy: benefits and requirements of localisation, diagnosis, and intraoperative PTH monitoring. Long term results. World J Surg 33:2256–2265CrossRefPubMed Fraker DL, Harsono H, Lewis R (2009) Minimally invasive parathyroidectomy: benefits and requirements of localisation, diagnosis, and intraoperative PTH monitoring. Long term results. World J Surg 33:2256–2265CrossRefPubMed
32.
go back to reference Sebag F, Hubbard JG, Maweja S et al (2003) Negative preoperative localisation studies are highly predictive of multiglandular disease in sporadic primary hyperparathyroidism. Surgery 134:1038–1041CrossRefPubMed Sebag F, Hubbard JG, Maweja S et al (2003) Negative preoperative localisation studies are highly predictive of multiglandular disease in sporadic primary hyperparathyroidism. Surgery 134:1038–1041CrossRefPubMed
33.
go back to reference Miccoli P, Berti P, Conte M et al (2000) Minimally invasive video-assisted parathyroidectomy: lesson learned from 137 cases. J Am Coll Surg 191:613–618CrossRefPubMed Miccoli P, Berti P, Conte M et al (2000) Minimally invasive video-assisted parathyroidectomy: lesson learned from 137 cases. J Am Coll Surg 191:613–618CrossRefPubMed
34.
go back to reference Cook GJ, Wong JC, Smellie WJ (1998) [11C]Methionine positron emission tomography for patients with persistent or recurrent hyperparathyroidism after surgery. Eur J Endocrinol 139:195–197CrossRefPubMed Cook GJ, Wong JC, Smellie WJ (1998) [11C]Methionine positron emission tomography for patients with persistent or recurrent hyperparathyroidism after surgery. Eur J Endocrinol 139:195–197CrossRefPubMed
36.
go back to reference Ikeda Y, Takami H, Niimi M et al (2002) Endoscopic total parathyroidectomy by the anterior chest approach for renal hyperparathyroidism. Surg Endosc 16:320–322CrossRefPubMed Ikeda Y, Takami H, Niimi M et al (2002) Endoscopic total parathyroidectomy by the anterior chest approach for renal hyperparathyroidism. Surg Endosc 16:320–322CrossRefPubMed
37.
go back to reference Henry JF, Defechereux T, Gramatica L et al (1999) Minimally invasive video-assisted parathyroidectomy by lateral approach. Langenbecks Arch Surg 384:298–301CrossRefPubMed Henry JF, Defechereux T, Gramatica L et al (1999) Minimally invasive video-assisted parathyroidectomy by lateral approach. Langenbecks Arch Surg 384:298–301CrossRefPubMed
38.
go back to reference Miccoli P, Bendinelli C, Conte M et al (1998) Endoscopic parathyroidectomy by a gasless approach. J Laparoendosc Adv Surg Tech A 8:189–194CrossRefPubMed Miccoli P, Bendinelli C, Conte M et al (1998) Endoscopic parathyroidectomy by a gasless approach. J Laparoendosc Adv Surg Tech A 8:189–194CrossRefPubMed
39.
go back to reference Henry JF, Sebag F, Cherenko M et al (2008) Endoscopic parathyroidectomy: why and when? World J Surg 32:2509–2515CrossRefPubMed Henry JF, Sebag F, Cherenko M et al (2008) Endoscopic parathyroidectomy: why and when? World J Surg 32:2509–2515CrossRefPubMed
40.
go back to reference Lombardi CP, Raffaelli M, Traini E et al (2009) Video-assisted minimally invasive parathyroidectomy: benefits and long-term results. World J Surg 33:2266–2281CrossRefPubMed Lombardi CP, Raffaelli M, Traini E et al (2009) Video-assisted minimally invasive parathyroidectomy: benefits and long-term results. World J Surg 33:2266–2281CrossRefPubMed
41.
go back to reference Lombardi CP, Raffaelli M, Traini E et al (2008) Advantages of a video-assisted approach to parathyroidectomy. ORL J Otorhinolaryngol Relat Spec 70:313–318PubMed Lombardi CP, Raffaelli M, Traini E et al (2008) Advantages of a video-assisted approach to parathyroidectomy. ORL J Otorhinolaryngol Relat Spec 70:313–318PubMed
42.
go back to reference Berti P, Materazzi G, Picone A et al (2003) Limits and drawbacks of video-assisted parathyroidectomy. Br J Surg 90:743–747CrossRefPubMed Berti P, Materazzi G, Picone A et al (2003) Limits and drawbacks of video-assisted parathyroidectomy. Br J Surg 90:743–747CrossRefPubMed
43.
go back to reference Henry JF, Sebag F, Tamagnini P et al (2004) Endoscopic parathyroid surgery: results of 365 consecutive procedures. World J Surg 28:1219–1223CrossRefPubMed Henry JF, Sebag F, Tamagnini P et al (2004) Endoscopic parathyroid surgery: results of 365 consecutive procedures. World J Surg 28:1219–1223CrossRefPubMed
44.
go back to reference Arnalsteen LC, Alesina PF, Quiereux JL et al (2002) Long-term results of less than total parathyroidectomy for hyperparathyroidism in multiple endocrine neoplasia type 1. Surgery 132:1119–1125CrossRefPubMed Arnalsteen LC, Alesina PF, Quiereux JL et al (2002) Long-term results of less than total parathyroidectomy for hyperparathyroidism in multiple endocrine neoplasia type 1. Surgery 132:1119–1125CrossRefPubMed
Metadata
Title
Video-Assisted Bilateral Neck Exploration in Patients with Primary Hyperparathyroidism and Failed Localization Studies
Authors
Pier F. Alesina
Reyaz M. Singaporewalla
Martin K. Walz
Publication date
01-10-2010
Publisher
Springer-Verlag
Published in
World Journal of Surgery / Issue 10/2010
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI
https://doi.org/10.1007/s00268-010-0700-4

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