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World Journal of Surgery

Published in:

01-05-2010

C-reactive Protein −717C>T Genetic Polymorphism Associates with Esophagectomy-induced Stress Hyperglycemia

Authors: Satoru Motoyama, Masatomo Miura, Yudai Hinai, Kiyotomi Maruyama, Katsuyuki Murata, Jun-ichi Ogawa

Published in: World Journal of Surgery | Issue 5/2010

Abstract

Background

Stress hyperglycemia refers to the transient hyperglycemia seen during illness and is usually restricted to patients without previous evidence of diabetes. The influence of genetics on surgery-induced hyperglycemia remains only partially understood.

Methods

The study participants were Japanese patients treated for thoracic esophageal cancer with curative esophagectomy at Akita University Hospital between 2003 and 2007. We determined the associations between esophagectomy-induced stress hyperglycemia (≥30 mg/dl increases in blood glucose during surgery) and genetic polymorphisms for C-reactive protein (CRP), tumor necrosis factor (TNF)-α, -β, interferon-γ, transforming growth factor-β1, interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-6 receptors, IL-10, IL-12β, adiponectin, and peroxisome proliferator-activated receptor-γ.

Results

In 28 (46%) patients, blood glucose levels increased more than 30 mg/dl during surgery. Among the genetic polymorphisms tested, CRP −717C>T was significantly associated with stress hyperglycemia during esophagectomy. Multivariate logistic regression revealed that patients with the CRP −717T/T genotype had a significantly greater risk of developing surgery-induced hyperglycemia than those with the CRP −717C/T genotype. Stress hyperglycemia was also significantly associated with postoperative infectious complications and duration of intensive care unit stay.

Conclusions

It is suggested that CRP −717 C>T genetic polymorphism may be a predictive factor for stress hyperglycemia in patients receiving esophagectomy for thoracic esophageal cancer.

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Title: C-reactive Protein −717C>T Genetic Polymorphism Associates with Esophagectomy-induced Stress Hyperglycemia
Authors: Satoru Motoyama
Masatomo Miura
Yudai Hinai
Kiyotomi Maruyama
Katsuyuki Murata
Jun-ichi Ogawa
Publication date: 01-05-2010
Publisher: Springer-Verlag
Published in: World Journal of Surgery / Issue 5/2010
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-010-0456-x

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

C-reactive Protein −717C>T Genetic Polymorphism Associates with Esophagectomy-induced Stress Hyperglycemia

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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