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World Journal of Surgery

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01-03-2010

Intrabiliary Rupture of Hepatic Echinococcosis, a Risk Factor for Developing Postoperative Morbidity: A Cohort Study

Authors: Carlos Manterola, Manuel Vial, Antonio Sanhueza, Juan Contreras

Published in: World Journal of Surgery | Issue 3/2010

Abstract

Background

The aim of this study was to determine if intrabiliary rupture (IBR), an evolutive complication of hepatic echinococcosis (HE), is a risk factor for developing postoperative morbidity (POM).

Methods

This was a concurrent cohort study that included patients operated on for HE between 1996 and 2006 and who had clinical check-ups at 1, 6, 12, 24, 36, 48, and 60 months postoperatively. Principal outcome variable was “development POM,” considered dichotomously. The exposure variable was the presence of IBR, analyzed dichotomously (present or absent) and according to the number of IBR (without, with one, and with two or more). The sample size was considered on the basis of a 95% confidence interval (95% CI), a power of 80%, a 1:2 ratio of patients without and with IBR, and a 10% proportion of POM in patients without IBR and 26% in patients with IBR. Descriptive statistics and bivariate and multivariate analyses were used. Relative risks (RR) and 95% CI were calculated.

Results

The cohorts (median age of 42 years, 56.4% female, a median cyst diameter of 15 cm, and a follow-up of 118 months) were composed of 96 patients without IBR (38.1%) and 156 patients with IBR (61.9%). A morbidity rate of 17.1% was verified (9.4% in the group without IBR and 21.8% in the group with IBR [p = 0.011]). An adjusted RR of 3.4 (95% CI = 2.64, 4.18) was verified for the comparison of subgroups without IBR vs. with two or more IBR (p < 0.001).

Conclusion

The presence of two or more IBR constitutes a risk factor for developing POM in patients with HE.

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Title: Intrabiliary Rupture of Hepatic Echinococcosis, a Risk Factor for Developing Postoperative Morbidity: A Cohort Study
Authors: Carlos Manterola
Manuel Vial
Antonio Sanhueza
Juan Contreras
Publication date: 01-03-2010
Publisher: Springer-Verlag
Published in: World Journal of Surgery / Issue 3/2010
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-009-0322-x

At a glance: The STEP trials

Springer Medicine

Intrabiliary Rupture of Hepatic Echinococcosis, a Risk Factor for Developing Postoperative Morbidity: A Cohort Study

Abstract

Background

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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