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Published in: World Journal of Surgery 4/2010

01-04-2010

The Long Road to Pancreatic Islet Transplantation

Authors: Mark A. Hardy, Piotr Witkowski, Hugo Sondermeijer, Paul Harris

Published in: World Journal of Surgery | Issue 4/2010

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Excerpt

One of us (M.A.H.) has known Dr. Eric Rose since he was a resident at Columbia University, then when he became a fellow in cardiothoracic surgery, and later, when he became a director, first of the heart transplantation program, then of the Cardiothoracic Division, and finally as Valentine Mott/Johnson & Johnson Professor and Chairman of the Department of Surgery, a position he has held for the last 14 years. Having this long relationship with Dr. Rose, I was not sure where or how to begin this tribute to my former resident, long-time colleague and collaborator, and eventually director. It was as an innovative and courageous Chairman that Dr. Rose had a major impact on me when he appointed me as a Residency Program Director. Through his remarkable interest and support of educational changes, the surgical residency at Columbia-NY Presbyterian Hospital has become one of the leading programs in the country. But the greatest inspiration that Dr. Rose brought to the Department of Surgery was his fearless and relentless support of ventures into the unknown. When faced with formalizing heart transplantation as a junior faculty member, he went on to lay the foundation for the largest heart transplant program in the world; when challenged by development and lack of acceptance of left ventricular assist devices, he guided their approval after appropriate multi-institutional studies had led to their adoption as standard of care. His influence extended to the support of a Pancreatic Islet Transplantation Program inspired by his predecessor and mentor, Dr. Keith Reemtsma. Doctor Rose invested in and encouraged both the clinical and experimental development of this program under my guidance as part of his dedication to innovation. …
Literature
1.
go back to reference Kaddis JS, Olack BJ, Sowinski J et al (2009) Human pancreatic islets and diabetes research. JAMA 301:1580–1587CrossRefPubMed Kaddis JS, Olack BJ, Sowinski J et al (2009) Human pancreatic islets and diabetes research. JAMA 301:1580–1587CrossRefPubMed
2.
go back to reference Ryan EA, Paty BW, Senior PA et al (2005) Five-year follow-up after clinical islet transplantation. Diabetes 54:2060CrossRefPubMed Ryan EA, Paty BW, Senior PA et al (2005) Five-year follow-up after clinical islet transplantation. Diabetes 54:2060CrossRefPubMed
3.
go back to reference Weber CJ, Hardy MA, Pi-Sunyer F et al (1978) Tissue culture preservation and intramuscular transplantation of pancreatic islets. Surgery 84:166PubMed Weber CJ, Hardy MA, Pi-Sunyer F et al (1978) Tissue culture preservation and intramuscular transplantation of pancreatic islets. Surgery 84:166PubMed
4.
go back to reference Richardson TP, Peters MC, Ennett AB et al (2001) Polymeric system for dual growth factor delivery. Nat Biotechnol 19:1029CrossRefPubMed Richardson TP, Peters MC, Ennett AB et al (2001) Polymeric system for dual growth factor delivery. Nat Biotechnol 19:1029CrossRefPubMed
5.
go back to reference Hersel U, Dahmen C, Kessler H (2003) RGD modified polymers: biomaterials for stimulated cell adhesion and beyond. Biomaterials 24:4385CrossRefPubMed Hersel U, Dahmen C, Kessler H (2003) RGD modified polymers: biomaterials for stimulated cell adhesion and beyond. Biomaterials 24:4385CrossRefPubMed
6.
go back to reference Pierschbacher MD, Ruoslahti E (1984) Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. Nature 309:30CrossRefPubMed Pierschbacher MD, Ruoslahti E (1984) Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. Nature 309:30CrossRefPubMed
7.
go back to reference Wang RN, Rosenberg L (1999) Maintenance of beta-cell function and survival following islet isolation requires re-establishment of the islet-matrix relationship. J Endocrinol 163:181CrossRefPubMed Wang RN, Rosenberg L (1999) Maintenance of beta-cell function and survival following islet isolation requires re-establishment of the islet-matrix relationship. J Endocrinol 163:181CrossRefPubMed
8.
go back to reference DePaz HA, Oluwole OO, Adeveri AO et al (2003) Immature rat myeloid dendritic cells generated in low dose granulocyte macrophage–colony stimulating factor prolong donor-specific rat cardiac allograft survival. Transplantation 75:521–528CrossRefPubMed DePaz HA, Oluwole OO, Adeveri AO et al (2003) Immature rat myeloid dendritic cells generated in low dose granulocyte macrophage–colony stimulating factor prolong donor-specific rat cardiac allograft survival. Transplantation 75:521–528CrossRefPubMed
9.
go back to reference Oluwole SF, Oluwole OO, DePaz HA et al (2003) CD4 + CD25 + regulatory T cells mediate acquired transplant tolerance. Transplant Immunol 11:287–293CrossRef Oluwole SF, Oluwole OO, DePaz HA et al (2003) CD4 + CD25 + regulatory T cells mediate acquired transplant tolerance. Transplant Immunol 11:287–293CrossRef
10.
go back to reference Yang DF, Qiu WH, Zhu HF et al (2008) CTLA4-Ig-modified dendritic cells inhibit lymphocyte-mediated alloimmune responses and prolong the islet graft survival in mice. Transpl Immunol 19:197–201CrossRefPubMed Yang DF, Qiu WH, Zhu HF et al (2008) CTLA4-Ig-modified dendritic cells inhibit lymphocyte-mediated alloimmune responses and prolong the islet graft survival in mice. Transpl Immunol 19:197–201CrossRefPubMed
11.
go back to reference Kedem A, Perets A, Gamlieli-Bonshtein I et al (2005) Vascular endothelial growth factor-releasing scaffolds enhance vascularization and engraftment of hepatocytes transplanted on liver lobes. Tissue Eng 11:715CrossRefPubMed Kedem A, Perets A, Gamlieli-Bonshtein I et al (2005) Vascular endothelial growth factor-releasing scaffolds enhance vascularization and engraftment of hepatocytes transplanted on liver lobes. Tissue Eng 11:715CrossRefPubMed
12.
go back to reference Chen RR, Silva EA, Yuen WW et al (2007) Spatio-temporal VEGF and PDGF delivery patterns blood vessel formation and maturation. Pharm Res 24:258CrossRefPubMed Chen RR, Silva EA, Yuen WW et al (2007) Spatio-temporal VEGF and PDGF delivery patterns blood vessel formation and maturation. Pharm Res 24:258CrossRefPubMed
13.
go back to reference Pinkse GG, Bouwman WP, Jiawan-Lalai R et al (2006) Integrin signaling via RGD peptides and anti-beta1 antibodies confers resistance to apoptosis in islets of Langerhans. Diabetes 55:312CrossRefPubMed Pinkse GG, Bouwman WP, Jiawan-Lalai R et al (2006) Integrin signaling via RGD peptides and anti-beta1 antibodies confers resistance to apoptosis in islets of Langerhans. Diabetes 55:312CrossRefPubMed
14.
go back to reference Witkowski, P, Sodermayeier H, Hardy MA et al. (in press) Islet grafting and imaging in a bioengineered intramuscular space. Transplantation Witkowski, P, Sodermayeier H, Hardy MA et al. (in press) Islet grafting and imaging in a bioengineered intramuscular space. Transplantation
15.
go back to reference Shapiro AM, Hao EG, Lakey JR et al (2001) Novel approaches toward early diagnosis of islet allograft rejection. Transplantation 71(12):1709CrossRefPubMed Shapiro AM, Hao EG, Lakey JR et al (2001) Novel approaches toward early diagnosis of islet allograft rejection. Transplantation 71(12):1709CrossRefPubMed
16.
go back to reference Maffei A, Liu Z, Witkowski P et al (2004) Identification of tissue-restricted transcripts in human islets. Endocrinology 145:4513–4521CrossRefPubMed Maffei A, Liu Z, Witkowski P et al (2004) Identification of tissue-restricted transcripts in human islets. Endocrinology 145:4513–4521CrossRefPubMed
17.
go back to reference Goland R, Freeby M, Parsey R et al (2009) 11C-Dihydrotetrabenazine PET of the pancreas in subjects with long-standing type 1 diabetes and in healthy controls. J Nucl Med 50:382–389CrossRefPubMed Goland R, Freeby M, Parsey R et al (2009) 11C-Dihydrotetrabenazine PET of the pancreas in subjects with long-standing type 1 diabetes and in healthy controls. J Nucl Med 50:382–389CrossRefPubMed
18.
go back to reference Souza F, Simpson N, Raffo A et al (2006) Longitudinal noninvasive PET-based beta cell mass estimates in a spontaneous diabetes rat model. J Clin Invest 116:1506–1513CrossRefPubMed Souza F, Simpson N, Raffo A et al (2006) Longitudinal noninvasive PET-based beta cell mass estimates in a spontaneous diabetes rat model. J Clin Invest 116:1506–1513CrossRefPubMed
Metadata
Title
The Long Road to Pancreatic Islet Transplantation
Authors
Mark A. Hardy
Piotr Witkowski
Hugo Sondermeijer
Paul Harris
Publication date
01-04-2010
Publisher
Springer-Verlag
Published in
World Journal of Surgery / Issue 4/2010
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI
https://doi.org/10.1007/s00268-009-0246-5

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