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Published in: World Journal of Surgery 7/2009

Open Access 01-07-2009

Operative Debridement of Pressure Ulcers

Authors: Jessica Schiffman, Michael S. Golinko, Alan Yan, Anna Flattau, Marjana Tomic-Canic, Harold Brem

Published in: World Journal of Surgery | Issue 7/2009

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Abstract

Background

Infection in severe pressure ulcers can lead to sepsis with a 6-month mortality as high as 68%.

Methods

Operative records of 142 consecutive operative debridements on 60 patients in a dedicated wound healing inpatient unit were reviewed, from the Wound Electronic Medical Record, for identification of key steps in debridement technique, mortality, unexpected returns, and time to discharge following debridement.

Results

The mean age of the patients was 73.1 years, and 45% were men. Most wounds (53%) were located on the hip (ischial or trochanteric); others were on the sacrum (32%) and the heels (14%). The mean initial wound area prior to debridement was 14.0 cm2, and 83% of debridements were performed on stage IV pressure ulcers. The postoperative hospital stay averaged 4.1 days. Key steps in the technique included (1) exposure of areas of undermining by excising overlying tissue; (2) removal of callus from wound edges; (3) removal of all grossly infected tissue; and (4) obtaining a biopsy of the deep tissue after debridement of all nonviable or infected tissue for culture and pathology to determine the presence of infection, fibrosis, and granulation tissue. There was one death 9 days post-debridement of a sacral ulcer and one unplanned return to the operating room for bleeding 8 days post-debridement.

Conclusions

Operative debridement of pressure ulcers is safe, despite the medical co-morbidities in patients with severe pressure ulcers. Proper debridement technique may prevent sepsis and death in patients with multiple co-morbid conditions.
Literature
1.
go back to reference Baumgarten M, Margolis DJ, Localio AR, Kagan SH, Lowe RA, Kinosian B, Holmes JH, Abbuhl SB, Kavesh W, Ruffin A (2006) Pressure ulcers among elderly patients early in the hospital stay. J Gerontol A Biol Sci Med Sci 61:749–754PubMed Baumgarten M, Margolis DJ, Localio AR, Kagan SH, Lowe RA, Kinosian B, Holmes JH, Abbuhl SB, Kavesh W, Ruffin A (2006) Pressure ulcers among elderly patients early in the hospital stay. J Gerontol A Biol Sci Med Sci 61:749–754PubMed
2.
go back to reference Horn SD, Bender SA, Bergstrom N, Cook AS, Ferguson ML, Rimmasch HL, Sharkey SS, Smout RJ, Taler GA, Voss AC (2002) Description of the National Pressure Ulcer Long-Term Care Study. J Am Geriatr Soc 50:1816–1825PubMedCrossRef Horn SD, Bender SA, Bergstrom N, Cook AS, Ferguson ML, Rimmasch HL, Sharkey SS, Smout RJ, Taler GA, Voss AC (2002) Description of the National Pressure Ulcer Long-Term Care Study. J Am Geriatr Soc 50:1816–1825PubMedCrossRef
4.
go back to reference Brown G (2003) Long-term outcomes of full-thickness pressure ulcers: healing and mortality. Ostomy Wound Manage 49:42–50PubMed Brown G (2003) Long-term outcomes of full-thickness pressure ulcers: healing and mortality. Ostomy Wound Manage 49:42–50PubMed
6.
go back to reference Gawlitta D, Li W, Oomens CW, Baaijens FP, Bader DL, Bouten CV (2007) The relative contributions of compression and hypoxia to development of muscle tissue damage: an in vitro study. Ann Biomed Eng 35:273–284PubMedCrossRef Gawlitta D, Li W, Oomens CW, Baaijens FP, Bader DL, Bouten CV (2007) The relative contributions of compression and hypoxia to development of muscle tissue damage: an in vitro study. Ann Biomed Eng 35:273–284PubMedCrossRef
7.
go back to reference Supp DM, Boyce ST (2005) Engineered skin substitutes: practices and potentials. Clin Dermatol 23:403–412PubMedCrossRef Supp DM, Boyce ST (2005) Engineered skin substitutes: practices and potentials. Clin Dermatol 23:403–412PubMedCrossRef
8.
go back to reference Tsuji S, Ichioka S, Sekiya N, Nakatsuka T (2005) Analysis of ischemia–reperfusion injury in a microcirculatory model of pressure ulcers. Wound Repair Regen 13:209–215PubMedCrossRef Tsuji S, Ichioka S, Sekiya N, Nakatsuka T (2005) Analysis of ischemia–reperfusion injury in a microcirculatory model of pressure ulcers. Wound Repair Regen 13:209–215PubMedCrossRef
9.
go back to reference Bouten CV, Oomens CW, Baaijens FP, Bader DL (2003) The etiology of pressure ulcers: skin deep or muscle bound? Arch Phys Med Rehabil 84:616–619PubMedCrossRef Bouten CV, Oomens CW, Baaijens FP, Bader DL (2003) The etiology of pressure ulcers: skin deep or muscle bound? Arch Phys Med Rehabil 84:616–619PubMedCrossRef
10.
go back to reference Edsberg LE (2007) Pressure ulcer tissue histology: an appraisal of current knowledge. Ostomy Wound Manage 53:40–49PubMed Edsberg LE (2007) Pressure ulcer tissue histology: an appraisal of current knowledge. Ostomy Wound Manage 53:40–49PubMed
11.
go back to reference Stojadinovic O, Brem H, Vouthounis C, Lee B, Fallon J, Stallcup M, Merchant A, Galiano RD, Tomic-Canic M (2005) Molecular pathogenesis of chronic wounds: the role of beta-catenin and c-myc in the inhibition of epithelialization and wound healing. Am J Pathol 167:59–69PubMed Stojadinovic O, Brem H, Vouthounis C, Lee B, Fallon J, Stallcup M, Merchant A, Galiano RD, Tomic-Canic M (2005) Molecular pathogenesis of chronic wounds: the role of beta-catenin and c-myc in the inhibition of epithelialization and wound healing. Am J Pathol 167:59–69PubMed
12.
go back to reference Agren M, Stromberg H (1985) Topical treatment of pressure ulcers: a randomized comparative trial of Varidase and zinc oxide. Scand J Plast Reconstr Surg 19:97–100PubMedCrossRef Agren M, Stromberg H (1985) Topical treatment of pressure ulcers: a randomized comparative trial of Varidase and zinc oxide. Scand J Plast Reconstr Surg 19:97–100PubMedCrossRef
13.
go back to reference Galpin J, Chow A, Bayer A, Guze L (1976) Sepsis associated with decubitus ulcers. Am J Med 61:346–350PubMedCrossRef Galpin J, Chow A, Bayer A, Guze L (1976) Sepsis associated with decubitus ulcers. Am J Med 61:346–350PubMedCrossRef
14.
go back to reference Longe R (1986) Current concepts in clinical therapeutics: pressure sores. Clin Pharm 5:669–681PubMed Longe R (1986) Current concepts in clinical therapeutics: pressure sores. Clin Pharm 5:669–681PubMed
15.
go back to reference Bergstrom N (1994) AHCPR supported clinical practice guidelines in treatment of pressure ulcers. National Library of Medicine, Bethesda, MD Bergstrom N (1994) AHCPR supported clinical practice guidelines in treatment of pressure ulcers. National Library of Medicine, Bethesda, MD
16.
go back to reference Niezgoda JA, Mendez-Eastman S (2006) The effective management of pressure ulcers. Adv Skin Wound Care 19(Suppl 1):3–15PubMedCrossRef Niezgoda JA, Mendez-Eastman S (2006) The effective management of pressure ulcers. Adv Skin Wound Care 19(Suppl 1):3–15PubMedCrossRef
17.
go back to reference Cannon B, O’Leary JJ, O’Neil JW, Steinsieck R (1950) An approach to the treatment of pressure sores. Ann Surg 132:760–778PubMedCrossRef Cannon B, O’Leary JJ, O’Neil JW, Steinsieck R (1950) An approach to the treatment of pressure sores. Ann Surg 132:760–778PubMedCrossRef
18.
go back to reference Black JM (1994) Surgical management of pressure ulcers. Nurs Clin North Am 29:801–808PubMed Black JM (1994) Surgical management of pressure ulcers. Nurs Clin North Am 29:801–808PubMed
19.
go back to reference Black JM, Black SB (1987) Surgical management of pressure ulcers. Nurs Clin North Am 22:429–438PubMed Black JM, Black SB (1987) Surgical management of pressure ulcers. Nurs Clin North Am 22:429–438PubMed
20.
go back to reference Bunt TJ (1983) Successful management of decubitus ulcers by the general surgeon. South Med J 76:453–455PubMed Bunt TJ (1983) Successful management of decubitus ulcers by the general surgeon. South Med J 76:453–455PubMed
21.
go back to reference Herceg SJ, Harding RL (1978) Surgical treatment of pressure ulcers. Arch Phys Med Rehabil 59:193–200PubMed Herceg SJ, Harding RL (1978) Surgical treatment of pressure ulcers. Arch Phys Med Rehabil 59:193–200PubMed
22.
go back to reference Linder RM, Morris D (1990) The surgical management of pressure ulcers: a systematic approach based on staging. Decubitus 3:32–38PubMed Linder RM, Morris D (1990) The surgical management of pressure ulcers: a systematic approach based on staging. Decubitus 3:32–38PubMed
23.
go back to reference Netscher D, Clamon J, Fincher L, Thompson R (1996) Surgical repair of pressure ulcers. Plast Surg Nurs 16:225–233, 239 Netscher D, Clamon J, Fincher L, Thompson R (1996) Surgical repair of pressure ulcers. Plast Surg Nurs 16:225–233, 239
24.
go back to reference Niazi ZB, Salzberg CA (1997) Operative repair of pressure ulcers. Clin Geriatr Med 13:587–597PubMed Niazi ZB, Salzberg CA (1997) Operative repair of pressure ulcers. Clin Geriatr Med 13:587–597PubMed
25.
go back to reference Niazi ZB, Salzberg CA (1997) Surgical management of pressure ulcers. Ostomy Wound Manage 43:44–48, 50–42 Niazi ZB, Salzberg CA (1997) Surgical management of pressure ulcers. Ostomy Wound Manage 43:44–48, 50–42
26.
go back to reference Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G (2003) 2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference. Crit Care Med 31:1250–1256PubMedCrossRef Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G (2003) 2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference. Crit Care Med 31:1250–1256PubMedCrossRef
27.
go back to reference Garner J, Javis W, Emori T, Horan T, Hughes J (1988) CDC definitions for nosocomial infections. Am J Infect Control 16:128–140PubMedCrossRef Garner J, Javis W, Emori T, Horan T, Hughes J (1988) CDC definitions for nosocomial infections. Am J Infect Control 16:128–140PubMedCrossRef
28.
go back to reference Sorensen J, Jorgensen B, Gottrup F (2004) Surgical treatment of pressure ulcers. Am J Surg 188:42S–51SCrossRef Sorensen J, Jorgensen B, Gottrup F (2004) Surgical treatment of pressure ulcers. Am J Surg 188:42S–51SCrossRef
30.
go back to reference Bouma BN, Mosnier LO (2006) Thrombin activatable fibrinolysis inhibitor (TAFI)—how does thrombin regulate fibrinolysis? Ann Med 38:378–388PubMedCrossRef Bouma BN, Mosnier LO (2006) Thrombin activatable fibrinolysis inhibitor (TAFI)—how does thrombin regulate fibrinolysis? Ann Med 38:378–388PubMedCrossRef
31.
go back to reference Weaver FA, Hood DB, Zatina M, Messina L, Badduke B (2002) Gelatin-thrombin-based hemostatic sealant for intraoperative bleeding in vascular surgery. Ann Vasc Surg 16:286–293PubMedCrossRef Weaver FA, Hood DB, Zatina M, Messina L, Badduke B (2002) Gelatin-thrombin-based hemostatic sealant for intraoperative bleeding in vascular surgery. Ann Vasc Surg 16:286–293PubMedCrossRef
32.
go back to reference Sirlak M, Eryilmaz S, Yazicioglu L, Kiziltepe U, Eyileten Z, Durdu MS, Tasoz R, Eren NT, Aral A, Kaya B, Akalin H (2003) Comparative study of microfibrillar collagen hemostat (Colgel) and oxidized cellulose (Surgicel) in high transfusion-risk cardiac surgery. J Thorac Cardiovasc Surg 126:666–670PubMedCrossRef Sirlak M, Eryilmaz S, Yazicioglu L, Kiziltepe U, Eyileten Z, Durdu MS, Tasoz R, Eren NT, Aral A, Kaya B, Akalin H (2003) Comparative study of microfibrillar collagen hemostat (Colgel) and oxidized cellulose (Surgicel) in high transfusion-risk cardiac surgery. J Thorac Cardiovasc Surg 126:666–670PubMedCrossRef
33.
go back to reference De Vries HJ, Mekkes JR, Middelkoop E, Hinrichs WL, Wildevuur CR, Westerhof W (1993) Dermal substitutes for full-thickness wounds in a one-stage grafting model. Wound Repair Regen 1:244–252PubMedCrossRef De Vries HJ, Mekkes JR, Middelkoop E, Hinrichs WL, Wildevuur CR, Westerhof W (1993) Dermal substitutes for full-thickness wounds in a one-stage grafting model. Wound Repair Regen 1:244–252PubMedCrossRef
34.
go back to reference Kucan JO, Robson MC, Heggers JP, Ko F (1981) Comparison of silver sulfadiazine, povidone-iodine and physiologic saline in the treatment of chronic pressure ulcers. J Am Geriatr Soc 29:232–235PubMed Kucan JO, Robson MC, Heggers JP, Ko F (1981) Comparison of silver sulfadiazine, povidone-iodine and physiologic saline in the treatment of chronic pressure ulcers. J Am Geriatr Soc 29:232–235PubMed
35.
go back to reference Lee LK, Ambrus JL (1975) Collagenase therapy for decubitus ulcers. Geriatrics 30(91–93):97–98 Lee LK, Ambrus JL (1975) Collagenase therapy for decubitus ulcers. Geriatrics 30(91–93):97–98
36.
go back to reference Moberg S, Hoffman L, Grennert ML, Holst A (1983) A randomized trial of cadexomer iodine in decubitus ulcers. J Am Geriatr Soc 31:462–465PubMed Moberg S, Hoffman L, Grennert ML, Holst A (1983) A randomized trial of cadexomer iodine in decubitus ulcers. J Am Geriatr Soc 31:462–465PubMed
37.
go back to reference Brem H, Lyder C (2004) Protocol for the successful treatment of pressure ulcers. Am J Surg 188:9–17PubMedCrossRef Brem H, Lyder C (2004) Protocol for the successful treatment of pressure ulcers. Am J Surg 188:9–17PubMedCrossRef
38.
go back to reference Schuster R, Moradzadeh A, Waxman K (2006) The use of vacuum-assisted closure therapy for the treatment of a large infected facial wound. Am Surg 72:129–131PubMed Schuster R, Moradzadeh A, Waxman K (2006) The use of vacuum-assisted closure therapy for the treatment of a large infected facial wound. Am Surg 72:129–131PubMed
39.
go back to reference Whitney J, Phillips L, Aslam R, Barbul A, Gottrup F, Gould L, Robson MC, Rodeheaver G, Thomas D, Stotts N (2006) Guidelines for the treatment of pressure ulcers. Wound Repair Regen 14:663–679PubMedCrossRef Whitney J, Phillips L, Aslam R, Barbul A, Gottrup F, Gould L, Robson MC, Rodeheaver G, Thomas D, Stotts N (2006) Guidelines for the treatment of pressure ulcers. Wound Repair Regen 14:663–679PubMedCrossRef
40.
go back to reference Schryvers OI, Stranc MF, Nance PW (2000) Surgical treatment of pressure ulcers: 20-year experience. Arch Phys Med Rehabil 81:1556–1562PubMedCrossRef Schryvers OI, Stranc MF, Nance PW (2000) Surgical treatment of pressure ulcers: 20-year experience. Arch Phys Med Rehabil 81:1556–1562PubMedCrossRef
41.
go back to reference Allman RM, Goode PS, Burst N, Bartolucci AA, Thomas DR (1999) Pressure ulcers, hospital complications, and disease severity: impact on hospital costs and length of stay. Adv Wound Care 12:22–30PubMed Allman RM, Goode PS, Burst N, Bartolucci AA, Thomas DR (1999) Pressure ulcers, hospital complications, and disease severity: impact on hospital costs and length of stay. Adv Wound Care 12:22–30PubMed
42.
go back to reference Brem H, Stojadinovic O, Diegelmann RF, Entero H, Lee B, Pastar I, Golinko M, Rosenberg H, Tomic-Canic M (2007) Molecular markers in patients with chronic wounds to guide surgical debridement. Mol Med 13:30–39PubMedCrossRef Brem H, Stojadinovic O, Diegelmann RF, Entero H, Lee B, Pastar I, Golinko M, Rosenberg H, Tomic-Canic M (2007) Molecular markers in patients with chronic wounds to guide surgical debridement. Mol Med 13:30–39PubMedCrossRef
43.
go back to reference Stojadinovic O, Pastar I, Vukelic S, Mahoney MG, Brennan D, Krzyzanowska A, Golinko M, Brem H, Tomic-Canic M (2008) Deregulation of keratinocyte differentiation and activation: a hallmark of venous ulcers. J Cell Mol Med 12:2675–2690PubMedCrossRef Stojadinovic O, Pastar I, Vukelic S, Mahoney MG, Brennan D, Krzyzanowska A, Golinko M, Brem H, Tomic-Canic M (2008) Deregulation of keratinocyte differentiation and activation: a hallmark of venous ulcers. J Cell Mol Med 12:2675–2690PubMedCrossRef
44.
go back to reference Fleisher LA, Beckman JA, Brown KA, Calkins H, Chaikof EL, Fleischmann KE, Freeman WK, Froehlich JB, Kasper EK, Kersten JR et al (2007) ACC/AHA 2006 guideline update on perioperative cardiovascular evaluation for noncardiac surgery: focused update on perioperative beta-blocker therapy—a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2002 Guidelines on perioperative cardiovascular evaluation for noncardiac surgery). Anesth Analg 104:15–26PubMedCrossRef Fleisher LA, Beckman JA, Brown KA, Calkins H, Chaikof EL, Fleischmann KE, Freeman WK, Froehlich JB, Kasper EK, Kersten JR et al (2007) ACC/AHA 2006 guideline update on perioperative cardiovascular evaluation for noncardiac surgery: focused update on perioperative beta-blocker therapy—a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2002 Guidelines on perioperative cardiovascular evaluation for noncardiac surgery). Anesth Analg 104:15–26PubMedCrossRef
45.
go back to reference Kuwahara M, Tada H, Mashiba K, Yurugi S, Iioka H, Niitsuma K, Yasuda Y (2005) Mortality and recurrence rate after pressure ulcer operation for elderly long-term bedridden patients. Ann Plast Surg 54:629–632PubMedCrossRef Kuwahara M, Tada H, Mashiba K, Yurugi S, Iioka H, Niitsuma K, Yasuda Y (2005) Mortality and recurrence rate after pressure ulcer operation for elderly long-term bedridden patients. Ann Plast Surg 54:629–632PubMedCrossRef
46.
go back to reference Han H, Lewis VL Jr, Wiedrich TA, Patel PK (2002) The value of Jamshidi core needle bone biopsy in predicting postoperative osteomyelitis in grade IV pressure ulcer patients. Plast Reconstr Surg 110:118–122PubMedCrossRef Han H, Lewis VL Jr, Wiedrich TA, Patel PK (2002) The value of Jamshidi core needle bone biopsy in predicting postoperative osteomyelitis in grade IV pressure ulcer patients. Plast Reconstr Surg 110:118–122PubMedCrossRef
Metadata
Title
Operative Debridement of Pressure Ulcers
Authors
Jessica Schiffman
Michael S. Golinko
Alan Yan
Anna Flattau
Marjana Tomic-Canic
Harold Brem
Publication date
01-07-2009
Publisher
Springer-Verlag
Published in
World Journal of Surgery / Issue 7/2009
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI
https://doi.org/10.1007/s00268-009-0024-4

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