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Published in: World Journal of Surgery 5/2008

Open Access 01-05-2008

Papillary Microcarcinoma

Authors: Shiro Noguchi, Hiroto Yamashita, Shinya Uchino, Shin Watanabe

Published in: World Journal of Surgery | Issue 5/2008

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Abstract

Background

Papillary microcarcinoma (PMC) is increasing in incidence because of diagnosis by ultrasound-guided fine-needle aspiration cytology.

Methods

Between January 1966 and December 1995, we treated 6019 patients with papillary cancer; among them, 2070 patients with PMC were studied.

Results

PMC is essentially very similar to papillary cancer that is 11 mm or larger and has a very good prognosis. Smaller tumors and younger patients have a better prognosis. Among PMC, larger tumors (6–10 mm) recur in 14% at 35 years compared with 3.3% in patients with smaller tumors. Patients older than 55 years have recurrence in 40% at 30 years, with a worse prognosis than younger patients who have a recurrence rate of less than 10%. Extracapsular invasion by the primary tumor also has a higher recurrence rate. The majority of recurrences are in the neck. Therefore, annual ultrasound of the neck is effective for recurrence surveillance.

Conclusion

Papillary microcarcinoma is similar to larger papillary carcinomas with tumor characteristics and age-based recurrence rate that extends for many years, justifying long surveillance after surgery.
Literature
1.
go back to reference Ito Y, Uruno T, Nakano K et al (2003) An observation trial without surgical treatment in patients with papillary microcarcinoma of the thyroid. Thyroid 13:381–387PubMedCrossRef Ito Y, Uruno T, Nakano K et al (2003) An observation trial without surgical treatment in patients with papillary microcarcinoma of the thyroid. Thyroid 13:381–387PubMedCrossRef
2.
go back to reference Kucuk NO, Tari P, Tokmak E et al (2007) Treatment for microcarcinoma of the thyroid—clinical experience. Clin Nucl Med 32:279–281PubMedCrossRef Kucuk NO, Tari P, Tokmak E et al (2007) Treatment for microcarcinoma of the thyroid—clinical experience. Clin Nucl Med 32:279–281PubMedCrossRef
3.
go back to reference Pelizzo MR, Boschin IM, Toniato A et al (2006) Papillary thyroid microcarcinoma (PTMC): prognostic factors, management and outcome in 403 patients. Eur J Surg Oncol 32:1144–1148PubMedCrossRef Pelizzo MR, Boschin IM, Toniato A et al (2006) Papillary thyroid microcarcinoma (PTMC): prognostic factors, management and outcome in 403 patients. Eur J Surg Oncol 32:1144–1148PubMedCrossRef
4.
go back to reference Fukunaga FH, Yatani R (1975) Geographic pathology of occult thyroid carcinomas. Cancer 36:1095–1099PubMedCrossRef Fukunaga FH, Yatani R (1975) Geographic pathology of occult thyroid carcinomas. Cancer 36:1095–1099PubMedCrossRef
5.
go back to reference Grant S, Luttrell B, Reeve T et al (1984) Thyroglobulin may be undetectable in the serum of patients with metastatic disease secondary to differentiated thyroid carcinoma. Follow-up of differentiated thyroid carcinoma. Cancer 54:1625–1628PubMedCrossRef Grant S, Luttrell B, Reeve T et al (1984) Thyroglobulin may be undetectable in the serum of patients with metastatic disease secondary to differentiated thyroid carcinoma. Follow-up of differentiated thyroid carcinoma. Cancer 54:1625–1628PubMedCrossRef
6.
go back to reference Noguchi S, Yamashita H, Murakami N et al (1996) Small carcinomas of the thyroid. A long-term follow-up of 867 patients. Arch Surg 131:187–191PubMed Noguchi S, Yamashita H, Murakami N et al (1996) Small carcinomas of the thyroid. A long-term follow-up of 867 patients. Arch Surg 131:187–191PubMed
7.
go back to reference Cady B, Rossi R, Silverman M et al (1985) Further evidence of the validity of risk group definition in differentiated thyroid carcinoma. Surgery 98:1171–1178PubMed Cady B, Rossi R, Silverman M et al (1985) Further evidence of the validity of risk group definition in differentiated thyroid carcinoma. Surgery 98:1171–1178PubMed
8.
go back to reference Chow SM, Law SC, Chan JK et al (2003) Papillary microcarcinoma of the thyroid: Prognostic significance of lymph node metastasis and multifocality. Cancer 98:31–40PubMedCrossRef Chow SM, Law SC, Chan JK et al (2003) Papillary microcarcinoma of the thyroid: Prognostic significance of lymph node metastasis and multifocality. Cancer 98:31–40PubMedCrossRef
9.
go back to reference Vini L, Hyer S, Pratt B et al (1999) Good prognosis in thyroid cancer found incidentally at surgery for thyrotoxicosis. Postgrad Med J 75:169–170PubMed Vini L, Hyer S, Pratt B et al (1999) Good prognosis in thyroid cancer found incidentally at surgery for thyrotoxicosis. Postgrad Med J 75:169–170PubMed
10.
go back to reference Belfiore A, Garofalo MR, Giuffrida D et al (1990) Increased aggressiveness of thyroid cancer in patients with Graves’ disease. J Clin Endocrinol Metab 70:830–835PubMedCrossRef Belfiore A, Garofalo MR, Giuffrida D et al (1990) Increased aggressiveness of thyroid cancer in patients with Graves’ disease. J Clin Endocrinol Metab 70:830–835PubMedCrossRef
11.
go back to reference Hales IB, McElduff A, Crummer P et al (1992) Does Graves’ disease or thyrotoxicosis affect the prognosis of thyroid cancer? J Clin Endocrinol Metab 75:886–889PubMedCrossRef Hales IB, McElduff A, Crummer P et al (1992) Does Graves’ disease or thyrotoxicosis affect the prognosis of thyroid cancer? J Clin Endocrinol Metab 75:886–889PubMedCrossRef
12.
go back to reference Kasuga Y, Sugenoya A, Kobayashi S et al (1993) The outcome of patients with thyroid carcinoma and Graves’ disease. Surg Today 23:9–12PubMedCrossRef Kasuga Y, Sugenoya A, Kobayashi S et al (1993) The outcome of patients with thyroid carcinoma and Graves’ disease. Surg Today 23:9–12PubMedCrossRef
13.
go back to reference Rassael H, Thompson LD, Heffess CS (1998) A rationale for conservative management of microscopic papillary carcinoma of the thyroid gland: a clinicopathologic correlation of 90 cases. Eur Arch Otorhinolaryngol 255:462–467PubMedCrossRef Rassael H, Thompson LD, Heffess CS (1998) A rationale for conservative management of microscopic papillary carcinoma of the thyroid gland: a clinicopathologic correlation of 90 cases. Eur Arch Otorhinolaryngol 255:462–467PubMedCrossRef
14.
go back to reference Salvadori B, Del Bo R, Pilotti S et al (1993) “Occult” papillary carcinoma of the thyroid: a questionable entity. Eur J Cancer 29A:1817–1820PubMedCrossRef Salvadori B, Del Bo R, Pilotti S et al (1993) “Occult” papillary carcinoma of the thyroid: a questionable entity. Eur J Cancer 29A:1817–1820PubMedCrossRef
15.
go back to reference Singh B, Shaha AR, Trivedi H et al (1999) Coexistent Hashimoto’s thyroiditis with papillary thyroid carcinoma: impact on presentation, management, and outcome. Surgery 126:1070–1076; discussion 1076–1077PubMedCrossRef Singh B, Shaha AR, Trivedi H et al (1999) Coexistent Hashimoto’s thyroiditis with papillary thyroid carcinoma: impact on presentation, management, and outcome. Surgery 126:1070–1076; discussion 1076–1077PubMedCrossRef
16.
go back to reference Derwahl M, Broecker M, Kraiem Z (1999) Clinical review 101: Thyrotropin may not be the dominant growth factor in benign and malignant thyroid tumors. J Clin Endocrinol Metab 84:829–834PubMedCrossRef Derwahl M, Broecker M, Kraiem Z (1999) Clinical review 101: Thyrotropin may not be the dominant growth factor in benign and malignant thyroid tumors. J Clin Endocrinol Metab 84:829–834PubMedCrossRef
17.
go back to reference Pelizzo MR, Boschin IM, Toniato A et al (2004) Natural history, diagnosis, treatment and outcome of papillary thyroid microcarcinoma (PTMC): a mono-institutional 12-year experience. Nucl Med Commun 25:547–552PubMedCrossRef Pelizzo MR, Boschin IM, Toniato A et al (2004) Natural history, diagnosis, treatment and outcome of papillary thyroid microcarcinoma (PTMC): a mono-institutional 12-year experience. Nucl Med Commun 25:547–552PubMedCrossRef
18.
go back to reference Sakorafas GH, Stafyla V, Kolettis T et al (2007) Microscopic papillary thyroid cancer as an incidental finding in patients treated surgically for presumably benign thyroid disease. J Postgrad Med 53:23–26PubMedCrossRef Sakorafas GH, Stafyla V, Kolettis T et al (2007) Microscopic papillary thyroid cancer as an incidental finding in patients treated surgically for presumably benign thyroid disease. J Postgrad Med 53:23–26PubMedCrossRef
19.
go back to reference Sanders LE, Rossi RL (1995) Occult well differentiated thyroid carcinoma presenting as cervical node disease. World J Surg 19:642–646; discussion 646–647PubMedCrossRef Sanders LE, Rossi RL (1995) Occult well differentiated thyroid carcinoma presenting as cervical node disease. World J Surg 19:642–646; discussion 646–647PubMedCrossRef
20.
go back to reference Furlan JC, Bedard Y, Rosen IB (2001) Biologic basis for the treatment of microscopic, occult well-differentiated thyroid cancer. Surgery 130:1050–1054PubMedCrossRef Furlan JC, Bedard Y, Rosen IB (2001) Biologic basis for the treatment of microscopic, occult well-differentiated thyroid cancer. Surgery 130:1050–1054PubMedCrossRef
21.
go back to reference Baudin E, Travagli JP, Ropers J et al (1998) Microcarcinoma of the thyroid gland: the Gustave-Roussy Institute experience. Cancer 83:553–559PubMedCrossRef Baudin E, Travagli JP, Ropers J et al (1998) Microcarcinoma of the thyroid gland: the Gustave-Roussy Institute experience. Cancer 83:553–559PubMedCrossRef
22.
go back to reference Rodriguez JM, Moreno A, Parrila P et al (1997) Papillary thyroid microcarcinoma: clinical study and prognosis. Eur J Surg 163:255–259PubMed Rodriguez JM, Moreno A, Parrila P et al (1997) Papillary thyroid microcarcinoma: clinical study and prognosis. Eur J Surg 163:255–259PubMed
Metadata
Title
Papillary Microcarcinoma
Authors
Shiro Noguchi
Hiroto Yamashita
Shinya Uchino
Shin Watanabe
Publication date
01-05-2008
Publisher
Springer-Verlag
Published in
World Journal of Surgery / Issue 5/2008
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI
https://doi.org/10.1007/s00268-007-9453-0

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