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Published in: World Journal of Surgery 9/2007

01-09-2007

Effect of Red Chili Consumption on Postoperative Symptoms During the Posthemorrhoidectomy Period: Randomized, Double-blind, Controlled Study

Author: Pravin J. Gupta

Published in: World Journal of Surgery | Issue 9/2007

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Abstract

The aim of this study was to determine whether there was any relation between consumption of chilies and postoperative symptoms after hemorrhoidectomy in patients with grade III or IV hemorrhoidal disease. A total of 60 patients were randomly assigned to receive antibiotics and analgesics alone (control patients) or daily consumption of 3 g of chili powder along with identical antibiotics and analgesics (chili group). The evaluation of symptoms—pain, anal burning, pruritus, bleeding—during the postoperative period was assessed by means of patients’ self-questionnaires. A global score for evaluating each postoperative symptom was compared between the two groups at the 1-week follow-up. No significant difference in age, sex distribution, or grade of disease was noted between the two groups at baseline. The incidence of posthemorrhoidectomy symptoms was higher in the group consuming chilies during the first postoperative week. The global score for postoperative pain (14.60 for the chili group vs. 7.97 for the control group, p < 0.001) and for anal burning (12.90 for the chili group vs. 7.82 for the control group, p < 0.0001) were significant. Although bleeding (6.95 in the control group and 7.57 in the chili group, p < 0.81) and pruritus (8.06 in the control group and 8.75 in the chili group, p < 0.69) were more common in the chili group, the difference did not achieve statistical significance. This study shows that consumption of 3 g of red chilies per day during the postoperative period after hemorrhoidectomy increases the intensity of typical postoperative symptoms, stool frequency, and the consumption of analgesics.
Literature
1.
go back to reference Desai HG, Venugopalan K, Antia FP (1973) Effect of red chili powder on DNA content of gastric aspirates. Gut 14:974–976PubMed Desai HG, Venugopalan K, Antia FP (1973) Effect of red chili powder on DNA content of gastric aspirates. Gut 14:974–976PubMed
2.
go back to reference Denis J (1976) A study of some etiological factors in hemorroidal disease (author’s transl). Arch Fr Mal App Dig 65:529–536PubMed Denis J (1976) A study of some etiological factors in hemorroidal disease (author’s transl). Arch Fr Mal App Dig 65:529–536PubMed
3.
go back to reference Brooks MH, Brooks R (1996) Red pepper effect. Br J Gen Pract 46:759PubMed Brooks MH, Brooks R (1996) Red pepper effect. Br J Gen Pract 46:759PubMed
4.
go back to reference Mende P, Siddiqi M, Preussmann R, et al. (1994) Identification of nitrophenols as nitrosation products from capsaicin and red chilies. Cancer Lett 83:277–282PubMedCrossRef Mende P, Siddiqi M, Preussmann R, et al. (1994) Identification of nitrophenols as nitrosation products from capsaicin and red chilies. Cancer Lett 83:277–282PubMedCrossRef
5.
go back to reference Agarwal MK, Bhatia SJ, Desai SA, et al. (2002) Effect of red chilies on small bowel and colonic transit and rectal sensitivity in men with irritable bowel syndrome. Indian J Gastroenterol 21:179–182PubMed Agarwal MK, Bhatia SJ, Desai SA, et al. (2002) Effect of red chilies on small bowel and colonic transit and rectal sensitivity in men with irritable bowel syndrome. Indian J Gastroenterol 21:179–182PubMed
6.
go back to reference al-Qarawi AA, Adam SE (1999) Effects of red chili (Capsicum frutescens L) on rats. Vet Hum Toxicol 41:293–295PubMed al-Qarawi AA, Adam SE (1999) Effects of red chili (Capsicum frutescens L) on rats. Vet Hum Toxicol 41:293–295PubMed
7.
go back to reference Lewis EA, Aderoju EA (1978) Factors in the aetiology of chronic duodenal ulcer in Ibadan. Trop Geogr Med 30:75–79PubMed Lewis EA, Aderoju EA (1978) Factors in the aetiology of chronic duodenal ulcer in Ibadan. Trop Geogr Med 30:75–79PubMed
8.
go back to reference Pigot F, Siproudhis L, Allaert FA (2005) Risk factors associated with hemorrhoidal symptoms in specialized consultation. Gastroenterol Clin Biol 29:1270–1274PubMedCrossRef Pigot F, Siproudhis L, Allaert FA (2005) Risk factors associated with hemorrhoidal symptoms in specialized consultation. Gastroenterol Clin Biol 29:1270–1274PubMedCrossRef
9.
go back to reference Jensen SL (1988) Diet and other risk factors for fissure-in-ano: prospective case control study. Dis Colon Rectum 31:770–773PubMedCrossRef Jensen SL (1988) Diet and other risk factors for fissure-in-ano: prospective case control study. Dis Colon Rectum 31:770–773PubMedCrossRef
10.
go back to reference Johanson JF, Sonnenberg A (1994) Constipation is not a risk factor for hemorrhoids: a case-control study of potential etiological agents. Am J Gastroenterol 89:1981–1986PubMed Johanson JF, Sonnenberg A (1994) Constipation is not a risk factor for hemorrhoids: a case-control study of potential etiological agents. Am J Gastroenterol 89:1981–1986PubMed
11.
go back to reference Delco F, Sonnenberg A (1998) Associations between hemorrhoids and other diagnoses. Dis Colon Rectum 41:1534–1541PubMedCrossRef Delco F, Sonnenberg A (1998) Associations between hemorrhoids and other diagnoses. Dis Colon Rectum 41:1534–1541PubMedCrossRef
12.
go back to reference Abdel-Salam OM, Szolcsanyi J, Mozsik G (1997) Capsaicin and the stomach: a review of experimental and clinical data. J Physiol Paris 91:151–171PubMedCrossRef Abdel-Salam OM, Szolcsanyi J, Mozsik G (1997) Capsaicin and the stomach: a review of experimental and clinical data. J Physiol Paris 91:151–171PubMedCrossRef
13.
go back to reference Schmulson MJ, Valdovinos MA, Milke P (2003) Chili pepper and rectal hyperalgesia in irritable bowel syndrome. Am J Gastroenterol 98:1214–1215PubMedCrossRef Schmulson MJ, Valdovinos MA, Milke P (2003) Chili pepper and rectal hyperalgesia in irritable bowel syndrome. Am J Gastroenterol 98:1214–1215PubMedCrossRef
14.
go back to reference Hoffmann P, Mazurkiewicz J, Holtmann G, et al. (2002) Capsaicin-sensitive nerve fibres induce epithelial cell proliferation, inflammatory cell immigration and transforming growth factor-alpha expression in the rat colonic mucosa in vivo. Scand J Gastroenterol 37:414–422PubMedCrossRef Hoffmann P, Mazurkiewicz J, Holtmann G, et al. (2002) Capsaicin-sensitive nerve fibres induce epithelial cell proliferation, inflammatory cell immigration and transforming growth factor-alpha expression in the rat colonic mucosa in vivo. Scand J Gastroenterol 37:414–422PubMedCrossRef
15.
go back to reference Nalini N, Manju V, Menon VP (2006) Effect of spices on lipid metabolism in 1,2-dimethylhydrazine-induced rat colon carcinogenesis. J Med Food 9:237–245PubMedCrossRef Nalini N, Manju V, Menon VP (2006) Effect of spices on lipid metabolism in 1,2-dimethylhydrazine-induced rat colon carcinogenesis. J Med Food 9:237–245PubMedCrossRef
16.
go back to reference Rajaratnam SS, Boyle N, Owen WJ (2001) ‘Always chew your chilies’: a report of small bowel obstruction with perforation. Int J Clin Pract 55:146PubMed Rajaratnam SS, Boyle N, Owen WJ (2001) ‘Always chew your chilies’: a report of small bowel obstruction with perforation. Int J Clin Pract 55:146PubMed
17.
go back to reference Altomare DF, Rinaldi M, La Torre F, et al. (2006) Red hot chili pepper and hemorrhoids: the explosion of a myth—results of a prospective, randomized, placebo-controlled, crossover trial. Dis Colon Rectum 49:1018–1023PubMedCrossRef Altomare DF, Rinaldi M, La Torre F, et al. (2006) Red hot chili pepper and hemorrhoids: the explosion of a myth—results of a prospective, randomized, placebo-controlled, crossover trial. Dis Colon Rectum 49:1018–1023PubMedCrossRef
18.
go back to reference Kumar N, Vij JC, Sarin SK, et al. (1984) Do chilies influence healing of duodenal ulcer? Br Med J (Clin Res Ed) 288:1803–1804CrossRef Kumar N, Vij JC, Sarin SK, et al. (1984) Do chilies influence healing of duodenal ulcer? Br Med J (Clin Res Ed) 288:1803–1804CrossRef
19.
go back to reference Siddiqi M, Kumar R, Fazili Z, et al. (1992) Increased exposure to dietary amines and nitrate in a population at high risk of oesophageal and gastric cancer in Kashmir (India). Carcinogenesis 13:1331–1335PubMedCrossRef Siddiqi M, Kumar R, Fazili Z, et al. (1992) Increased exposure to dietary amines and nitrate in a population at high risk of oesophageal and gastric cancer in Kashmir (India). Carcinogenesis 13:1331–1335PubMedCrossRef
21.
go back to reference Addy L, Antonarakis G (2005) Incisor toothwear caused by a dietary habit involving chilies: a case report. Dent Update 32:213–214, 216PubMed Addy L, Antonarakis G (2005) Incisor toothwear caused by a dietary habit involving chilies: a case report. Dent Update 32:213–214, 216PubMed
22.
go back to reference Balachandran B, Sivaramkrishnan VM (1995) Induction of tumours by Indian dietary constituents. Indian J Cancer 32:104–109PubMed Balachandran B, Sivaramkrishnan VM (1995) Induction of tumours by Indian dietary constituents. Indian J Cancer 32:104–109PubMed
23.
go back to reference Sielezneff I, Antoine K, Lecuyer J, et al. (1998) [Is there a correlation between dietary habits and hemorrhoidal disease?] Presse Med 27:513–517PubMed Sielezneff I, Antoine K, Lecuyer J, et al. (1998) [Is there a correlation between dietary habits and hemorrhoidal disease?] Presse Med 27:513–517PubMed
24.
go back to reference Kang JY, Alexander B, Barker F, et al. (1992) The effect of chili ingestion on gastrointestinal mucosal proliferation and azoxymethane-induced cancer in the rat. J Gastroenterol Hepatol 7:194–198PubMed Kang JY, Alexander B, Barker F, et al. (1992) The effect of chili ingestion on gastrointestinal mucosal proliferation and azoxymethane-induced cancer in the rat. J Gastroenterol Hepatol 7:194–198PubMed
25.
go back to reference Lysy J, Sistiery-Ittah M, Israelit Y, et al. (2003) Topical capsaicin—a novel and effective treatment for idiopathic intractable pruritus ani: a randomised, placebo controlled, crossover study. Gut 52:1323–1326PubMedCrossRef Lysy J, Sistiery-Ittah M, Israelit Y, et al. (2003) Topical capsaicin—a novel and effective treatment for idiopathic intractable pruritus ani: a randomised, placebo controlled, crossover study. Gut 52:1323–1326PubMedCrossRef
26.
go back to reference Anand P (2003) Capsaicin and menthol in the treatment of itch and pain: recently cloned receptors provide the key. Gut 52:1233–1235PubMedCrossRef Anand P (2003) Capsaicin and menthol in the treatment of itch and pain: recently cloned receptors provide the key. Gut 52:1233–1235PubMedCrossRef
Metadata
Title
Effect of Red Chili Consumption on Postoperative Symptoms During the Posthemorrhoidectomy Period: Randomized, Double-blind, Controlled Study
Author
Pravin J. Gupta
Publication date
01-09-2007
Publisher
Springer-Verlag
Published in
World Journal of Surgery / Issue 9/2007
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI
https://doi.org/10.1007/s00268-007-9148-6

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