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World Journal of Surgery
Published in: World Journal of Surgery 6/2007

01-06-2007

Early Postoperative Oral Feeding Accelerates Upper Gastrointestinal Anastomotic Healing in the Rat Model

Authors: Junya Fukuzawa, Hideo Terashima, Nobuhiro Ohkohchi

Published in: World Journal of Surgery | Issue 6/2007

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Abstract

Background

The benefits of early postoperative oral feeding following colonic anastomosis have previously been demonstrated. However, early postoperative oral feeding in patients with upper gastrointestinal surgery has been avoided because of concerns regarding anastomotic leakage. We investigated whether early postoperative oral feeding was advantageous for upper gastrointestinal anastomosis in comparison to parenteral feeding with a fasting period.

Materials and Methods

Male Sprague-Dawley rats were subjected to the same surgical manipulation, i.e., venous catheterization, gastrostomy, and proximal jejunal anastomosis. Rats were divided into two groups: the enteral nutrition (EN) group, which received nutrients via gastrostomy as a substitute for oral feeding, and the total parental nutrition (TPN) group, which was fed via a venous catheter. Identical nutritional solutions were administered to the two groups immediately after surgery. The anastomotic bursting pressure (ABP) and the content of hydroxyproline in the anastomotic tissue were measured 5 days postoperatively.

Results

The ABP in the EN group was significantly higher than that in the TPN group (214.6 ± 42 versus 149.5 ± 49 mmHg; p < 0.01). The hydroxyproline content in the EN group was also significantly higher (63.5 ± 10 versus 50.5 ± 12 μmol/g dry tissue; p < 0.01).

Conclusions

Early enteral feeding via gastrostomy accelerated jejunal anastomotic healing in comparison to parenteral feeding. This study clearly indicates that early oral feeding after upper gastrointestinal surgery leads to prompt anastomotic healing.
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Metadata
Title
Early Postoperative Oral Feeding Accelerates Upper Gastrointestinal Anastomotic Healing in the Rat Model
Authors
Junya Fukuzawa
Hideo Terashima
Nobuhiro Ohkohchi
Publication date
01-06-2007
Publisher
Springer-Verlag
Published in
World Journal of Surgery / Issue 6/2007
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI
https://doi.org/10.1007/s00268-007-9003-9

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