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01-09-2006

Evaluation of the Cardiovascular Risk in Patients with Subclinical Cushing Syndrome Before and After Surgery

Authors: Yeşim Erbil, MD, Evin Ademoğlu, MD, Neşe Özbey, MD, Umut Barbaros, MD, Burcu Tulumoğlu Yanık, MD, Artur Salmaslioğlu, MD, Alp Bozbora, MD, Selçuk Özarmağan, MD

Published in: World Journal of Surgery | Issue 9/2006

Abstract

Background

The widespread use of ultrasound, computerized tomography, and magnetic resonance imaging has led to an increase in the number of incidental adrenal masses identified. Asymptomatic incidentally discovered adrenal masses may indicate that subclinical Cushing syndrome (SCS) is not uncommon. We aimed to evaluate the cardiovascular risk of patients with SCS before and after surgery.

Methods

An autonomous cortisol-producing tumor was detected in 11 of 94 patients with adrenal incidentaloma between 1995 and 2005. Twenty-eight patients suffering from classical Cushing syndrome (CS) associated with unilateral adrenocortical adenoma, who were treated at our department in the same period, served as a control group. Cardiovascular risk factors such as blood pressure, body mass index, and lipid profile were evaluated before and 1 year after surgery.

Results

The frequency of hypertension (61% versus 63%), obesity (46% versus 55%), diabetes mellitus (50% versus 36%), hypercholesterolemia (39% versus 36%), and low HDL cholesterol (28% versus 36%) were not significantly different between CS and SCS patients, respectively. Adverse cardiovascular risk profile improved 1 year after adrenalectomy in both groups, although the changes were not significant with respect to body mass index, frequency of diabetes, and hyperlipidemia in SCS patients. But frequency of systolic/diastolic hypertension decreased significantly in this group.

Conclusions

These findings indicate that the increased incidence of cardiovascular risk factors commonly observed in classical CS, is also present in SCS. Unilateral adrenalectomy does not always lead to significant improvements in cardiovascular risk profile in SCS.

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Title: Evaluation of the Cardiovascular Risk in Patients with Subclinical Cushing Syndrome Before and After Surgery
Authors: Yeşim Erbil, MD
Evin Ademoğlu, MD
Neşe Özbey, MD
Umut Barbaros, MD
Burcu Tulumoğlu Yanık, MD
Artur Salmaslioğlu, MD
Alp Bozbora, MD
Selçuk Özarmağan, MD
Publication date: 01-09-2006
Publisher: Springer-Verlag
Published in: World Journal of Surgery / Issue 9/2006
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-005-0681-x

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Evaluation of the Cardiovascular Risk in Patients with Subclinical Cushing Syndrome Before and After Surgery

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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