Skip to main content
Top
Published in: World Journal of Surgery 12/2006

01-12-2006

Current Concepts in Anal Fissures

Authors: Abraham A. Ayantunde, FRCS, FWACS, Samuel A. Debrah, FRCS, FWACS

Published in: World Journal of Surgery | Issue 12/2006

Login to get access

Abstract

Introduction

Anal fissure is a common and distressing problem the true incidence of which is probably higher than recorded. There is a progressive understanding of the etiopathogenesis of this entity and the changing trend in its management approach. This is a systematic review of available published literature looking at current management options in anal fissures.

Methods

A MEDLINE-based search of the relevant literature from 1970 to 2004 was performed on the current concepts in etiopathogenesis and management of anal fissure.

Results

The current opinion is a drift toward conservative measures as the first- and second-line approaches rather than surgery for treatment of anal fissure. Simple and readily available measures with less complication, good patient compliance, and satisfaction requiring no hospitalization should first be considered.

Conclusions

Most anal fissures heal with medical therapy, but their limitations include side effects, poor compliance, and recurrence of the fissure. A cautious surgical approach is required to treat those who do not respond to medical therapy.
Literature
1.
go back to reference McCallion K, Gardiner KR. Progress in the understanding, treatment of chronic anal fissure. Postgrad Med J 2001;77:753–758PubMed McCallion K, Gardiner KR. Progress in the understanding, treatment of chronic anal fissure. Postgrad Med J 2001;77:753–758PubMed
2.
go back to reference Prescatori M, Interisano A. Annual report of the Italian coloproctology unit. Tech Coloproctol 1995;3:29–30 Prescatori M, Interisano A. Annual report of the Italian coloproctology unit. Tech Coloproctol 1995;3:29–30
3.
go back to reference Lund JN, Scholefield JH. Aetiology and treatment of anal fissure. Br J Surg 1996;83:1335–1344PubMed Lund JN, Scholefield JH. Aetiology and treatment of anal fissure. Br J Surg 1996;83:1335–1344PubMed
4.
go back to reference Frenckner B, Ihre T. Influence of autonomic nerves on the internal anal sphincter in man. Gut 1976;17:306–312PubMed Frenckner B, Ihre T. Influence of autonomic nerves on the internal anal sphincter in man. Gut 1976;17:306–312PubMed
5.
go back to reference Utzig MJ, Kroesen AJ, Buhr HJ. Concepts in pathogenesis and treatment of chronic anal fissure: a review of the literature. Am J Gastroenterol 2003;98:968–974PubMed Utzig MJ, Kroesen AJ, Buhr HJ. Concepts in pathogenesis and treatment of chronic anal fissure: a review of the literature. Am J Gastroenterol 2003;98:968–974PubMed
6.
go back to reference Farouk R, Duthie GS, MacGregor AB, et al. Sustained internal sphincter hypertonia in patients with chronic anal fissure. Dis Colon Rectum 1994;37:424–429PubMed Farouk R, Duthie GS, MacGregor AB, et al. Sustained internal sphincter hypertonia in patients with chronic anal fissure. Dis Colon Rectum 1994;37:424–429PubMed
7.
go back to reference Schouten WR, Briel JW, Auwerda JJA, et al. Ischaemic nature of anal fissure. Br J Surg 1996;83:63–65PubMed Schouten WR, Briel JW, Auwerda JJA, et al. Ischaemic nature of anal fissure. Br J Surg 1996;83:63–65PubMed
8.
go back to reference Gibbons CP, Read NW. Anal hypertonia in fissures: cause or effect? Br J Surg 1986;73:443–445PubMed Gibbons CP, Read NW. Anal hypertonia in fissures: cause or effect? Br J Surg 1986;73:443–445PubMed
9.
go back to reference Nothman BJ, Schuster MM. Internal anal sphincter derangement with anal fissures. Gastroenterology 1974;67:216–220 Nothman BJ, Schuster MM. Internal anal sphincter derangement with anal fissures. Gastroenterology 1974;67:216–220
10.
go back to reference Hancock BD. The internal sphincter and anal fissure. Br J Surg 1977;64:92–95PubMed Hancock BD. The internal sphincter and anal fissure. Br J Surg 1977;64:92–95PubMed
11.
go back to reference McDonald P, Driscoll AM, Nicholls RJ. The anal dilator in the conservative management of acute anal fissures. Br J Surg 1983;70:25–26PubMed McDonald P, Driscoll AM, Nicholls RJ. The anal dilator in the conservative management of acute anal fissures. Br J Surg 1983;70:25–26PubMed
12.
go back to reference Lock MR, Thompson JP. Fissure in ano: the initial management and prognosis. Br J Surg 1977;64:355–358PubMed Lock MR, Thompson JP. Fissure in ano: the initial management and prognosis. Br J Surg 1977;64:355–358PubMed
13.
go back to reference Gough MJ, Lewis A. The conservative treatment of fissure in ano. Br J Surg 1983;70:175–176PubMed Gough MJ, Lewis A. The conservative treatment of fissure in ano. Br J Surg 1983;70:175–176PubMed
14.
go back to reference Schouten WR, Briel JW, Auwerda JJA. Relationship between anal pressure and anodermal blood flow: the vascular pathogenesis of anal fissures. Dis Colon Rectum 1994;37:664–669PubMed Schouten WR, Briel JW, Auwerda JJA. Relationship between anal pressure and anodermal blood flow: the vascular pathogenesis of anal fissures. Dis Colon Rectum 1994;37:664–669PubMed
15.
go back to reference Schouten WR, Briel JW, Auwerda JJA, et al. Why do anal fissures heal after lateral sphincterotomy? Dis Colon Rectum 1995;37:9 Schouten WR, Briel JW, Auwerda JJA, et al. Why do anal fissures heal after lateral sphincterotomy? Dis Colon Rectum 1995;37:9
16.
go back to reference Jensen SL. Diet and other risk factors for fissure in ano: prospective case control study. Dis Colon Rectum 1988;31:770–773PubMed Jensen SL. Diet and other risk factors for fissure in ano: prospective case control study. Dis Colon Rectum 1988;31:770–773PubMed
17.
go back to reference Jensen SL. Treatment of first episodes of acute anal fissure: prospective randomized study of lignocaine ointment versus hydrocortisone ointment or warm sitz baths plus bran. BMJ 1986;292:1167–1169PubMed Jensen SL. Treatment of first episodes of acute anal fissure: prospective randomized study of lignocaine ointment versus hydrocortisone ointment or warm sitz baths plus bran. BMJ 1986;292:1167–1169PubMed
18.
go back to reference Jensen SL. Maintenance therapy with unprocessed bran in the prevention of acute anal fissure recurrence. J R Soc Med 1987;80:296–298PubMed Jensen SL. Maintenance therapy with unprocessed bran in the prevention of acute anal fissure recurrence. J R Soc Med 1987;80:296–298PubMed
19.
go back to reference Rattam S, Sarkar A, Chakder S. Nitric oxide pathway in rectoanal inhibitory reflex of opossum internal anal sphincter. Gastroenterology 1992;103:43–50 Rattam S, Sarkar A, Chakder S. Nitric oxide pathway in rectoanal inhibitory reflex of opossum internal anal sphincter. Gastroenterology 1992;103:43–50
20.
go back to reference O’Kelly V, Brading A, Mortensen N. Nerve mediated relaxation of the human internal anal sphincter: the role of nitric oxide. Gut 1993;34:689–693PubMed O’Kelly V, Brading A, Mortensen N. Nerve mediated relaxation of the human internal anal sphincter: the role of nitric oxide. Gut 1993;34:689–693PubMed
21.
go back to reference O’Kelly TJ. Nerves that say NO: a new perspective on the human rectoanal inhibitory reflex. Ann R Coll Surg Engl 1996;78:31–38PubMed O’Kelly TJ. Nerves that say NO: a new perspective on the human rectoanal inhibitory reflex. Ann R Coll Surg Engl 1996;78:31–38PubMed
22.
go back to reference Stebbing JF. Nitric oxide synthase neurones and neuromuscular behaviour of the anorectum. Ann R Coll Surg Engl 1998;80:137–145PubMed Stebbing JF. Nitric oxide synthase neurones and neuromuscular behaviour of the anorectum. Ann R Coll Surg Engl 1998;80:137–145PubMed
23.
go back to reference Guillemot F, Lone YC, Leroi H, et al. Nitroglycerine in situ reduces upper anal canal pressure. Dig Dis Sci 1992;37:155PubMed Guillemot F, Lone YC, Leroi H, et al. Nitroglycerine in situ reduces upper anal canal pressure. Dig Dis Sci 1992;37:155PubMed
24.
go back to reference Loder PB, Kamm MA, Nicholls RJ, et al. ‘Reversible chemical sphincterotomy’ by local application of glyceryl trinitrate. Br J Surg 1994;81:386–389 Loder PB, Kamm MA, Nicholls RJ, et al. ‘Reversible chemical sphincterotomy’ by local application of glyceryl trinitrate. Br J Surg 1994;81:386–389
25.
go back to reference Watson SJ, Kamm MA, Nicholls RJ, et al. Topical glyceryl trinitrate in the treatment of chronic anal fissure. Br J Surg 1996;83:771–775PubMed Watson SJ, Kamm MA, Nicholls RJ, et al. Topical glyceryl trinitrate in the treatment of chronic anal fissure. Br J Surg 1996;83:771–775PubMed
26.
go back to reference Guillemot F, Leroi H, Lone YC, et al. Action of in situ nitroglycerine on upper anal canal pressure of patients with terminal constipation: a pilot study. Dis Colon Rectum 1993;36:372–376PubMed Guillemot F, Leroi H, Lone YC, et al. Action of in situ nitroglycerine on upper anal canal pressure of patients with terminal constipation: a pilot study. Dis Colon Rectum 1993;36:372–376PubMed
27.
go back to reference Schouten WR, Briel JW, Boerma MO, et al. Pathophysiological aspects and clinical outcome of intra-anal application of isosorbide dinitrate in patients with chronic anal fissure [abstract]. Gut 1995;36(Suppl 1):A16 Schouten WR, Briel JW, Boerma MO, et al. Pathophysiological aspects and clinical outcome of intra-anal application of isosorbide dinitrate in patients with chronic anal fissure [abstract]. Gut 1995;36(Suppl 1):A16
28.
go back to reference Gorfine SR. Topical nitroglycerine therapy for anal fissures and ulcers [letter). N Engl J Med 1995;33:1156–1157 Gorfine SR. Topical nitroglycerine therapy for anal fissures and ulcers [letter). N Engl J Med 1995;33:1156–1157
29.
go back to reference Lund JN, Armitage NC, Scholefield JH. Use of glyceryl trinitrate in the treatment of anal fissure. Br J Surg 1996;83:776–777PubMed Lund JN, Armitage NC, Scholefield JH. Use of glyceryl trinitrate in the treatment of anal fissure. Br J Surg 1996;83:776–777PubMed
30.
go back to reference Carapeti EA, Kamm MA, McDonald PJ, et al. Randomized controlled trial shows that glyceryl trinitrate heals anal fissures, higher doses are not more effective, and there is a high recurrence rate. Gut 1999;44:727–730PubMedCrossRef Carapeti EA, Kamm MA, McDonald PJ, et al. Randomized controlled trial shows that glyceryl trinitrate heals anal fissures, higher doses are not more effective, and there is a high recurrence rate. Gut 1999;44:727–730PubMedCrossRef
31.
go back to reference Chaudhuri S, Pal AK, Acharya A, et al. Treatment of chronic anal fissure with topical glyceryl trinitrate: a double-blind, placebo-controlled trial. Indian J Gastroenterol 2001;20:101–102PubMed Chaudhuri S, Pal AK, Acharya A, et al. Treatment of chronic anal fissure with topical glyceryl trinitrate: a double-blind, placebo-controlled trial. Indian J Gastroenterol 2001;20:101–102PubMed
32.
go back to reference Lund JN, Scholefield JH. Glyceryl trinitrate is an effective treatment of anal fissure. Dis Colon Rectum 1997;40:468–470PubMed Lund JN, Scholefield JH. Glyceryl trinitrate is an effective treatment of anal fissure. Dis Colon Rectum 1997;40:468–470PubMed
33.
go back to reference Kennedy ML, Sowter S, Nguyen H, et al. Glycery trinitrate ointment in the treatment of chronic anal fissure: results of a placebo-controlled trial and long term follow-up. Dis Colon Rectum 1999;42:100–106 Kennedy ML, Sowter S, Nguyen H, et al. Glycery trinitrate ointment in the treatment of chronic anal fissure: results of a placebo-controlled trial and long term follow-up. Dis Colon Rectum 1999;42:100–106
34.
go back to reference Werre AJ, Palamba HW, Bilgen EJ, et al. Isosorbide dinitrate in the treatment of anal fissure: a randomized, prospective, double-blind, placebo-controlled trial. Eur J Surg 2001;167:382–385PubMed Werre AJ, Palamba HW, Bilgen EJ, et al. Isosorbide dinitrate in the treatment of anal fissure: a randomized, prospective, double-blind, placebo-controlled trial. Eur J Surg 2001;167:382–385PubMed
35.
go back to reference Lund JN, Scholefield JH. A randomized, prospective, double-blind, placebo-controlled trial of glyceryl trinitrate ointment in treatment of anal fissure. Lancet 1997;349:11–14PubMed Lund JN, Scholefield JH. A randomized, prospective, double-blind, placebo-controlled trial of glyceryl trinitrate ointment in treatment of anal fissure. Lancet 1997;349:11–14PubMed
36.
go back to reference Zuberi BF, Rajput MR, Abro H, et al. A randomized trial of glyceryl trinitrate ointment patch in healing anal fissures. Int J Colorectal Dis 2000;15:243–245PubMed Zuberi BF, Rajput MR, Abro H, et al. A randomized trial of glyceryl trinitrate ointment patch in healing anal fissures. Int J Colorectal Dis 2000;15:243–245PubMed
37.
go back to reference Bacher H, Misclinger HJ, Werkgartner G, et al. Local nitroglycerine for treatment of anal fissures: an alternative to lateral sphincterotomy? Dis Colon Rectum 1997;40:840–845PubMed Bacher H, Misclinger HJ, Werkgartner G, et al. Local nitroglycerine for treatment of anal fissures: an alternative to lateral sphincterotomy? Dis Colon Rectum 1997;40:840–845PubMed
38.
go back to reference Tander B, Guven A, Demirbag S, et al. A prospective, randomized, double-blind, placebo-controlled trial of glyceryl trinitrate ointment in the treatment of children with anal fissure. J Pediatr Surg 1999;34:1810–1812PubMed Tander B, Guven A, Demirbag S, et al. A prospective, randomized, double-blind, placebo-controlled trial of glyceryl trinitrate ointment in the treatment of children with anal fissure. J Pediatr Surg 1999;34:1810–1812PubMed
39.
go back to reference Simpson J, Lund JN, Thompson RJ, et al. The use of glyceryl trinitate (GTN) in the treatment of chronic anal fissure in children. Med Sci Monit 2003;9:123–126 Simpson J, Lund JN, Thompson RJ, et al. The use of glyceryl trinitate (GTN) in the treatment of chronic anal fissure in children. Med Sci Monit 2003;9:123–126
40.
go back to reference Lund JN, Parson SL, Scholefield JH. Spasm of internal anal sphincter in anal fissure—cause or effect [abstract]? Gastroenterology 1996;110:A711 Lund JN, Parson SL, Scholefield JH. Spasm of internal anal sphincter in anal fissure—cause or effect [abstract]? Gastroenterology 1996;110:A711
41.
go back to reference Altomare DF, Rinaldi M, Milito G, et al. Glyceryl trinitrate for chronic anal fissure—healing or headaches? Results of a multicentre, randomized, placebo-controlled, double-blind trial. Dis Colon Rectum 2000;43:174–181PubMed Altomare DF, Rinaldi M, Milito G, et al. Glyceryl trinitrate for chronic anal fissure—healing or headaches? Results of a multicentre, randomized, placebo-controlled, double-blind trial. Dis Colon Rectum 2000;43:174–181PubMed
42.
go back to reference Dorfman G, Levitt M, Platell C. Treatment of chronic anal fissure with topical glyceryl trinitrate. Dis Colon Rectum 1999;42:1007–1010PubMed Dorfman G, Levitt M, Platell C. Treatment of chronic anal fissure with topical glyceryl trinitrate. Dis Colon Rectum 1999;42:1007–1010PubMed
43.
go back to reference The Royal College of Surgeons of England in association with the Association of Coloproctology of Great Britain and Ireland. Analyses of 1997 study on anal fissure in children and adults, April 1998 The Royal College of Surgeons of England in association with the Association of Coloproctology of Great Britain and Ireland. Analyses of 1997 study on anal fissure in children and adults, April 1998
44.
go back to reference Jonas M, Lund JN, Scholefield JH. Topical 0.2% glyceryl trinitrate ointment for anal fissures: long-term efficacy in routine clinical practice. Colorectal Dis 2002;4:317–320PubMed Jonas M, Lund JN, Scholefield JH. Topical 0.2% glyceryl trinitrate ointment for anal fissures: long-term efficacy in routine clinical practice. Colorectal Dis 2002;4:317–320PubMed
45.
go back to reference Tankova L, Yoncheva K, Muhtarov M, et al. Topical mononitrate treatment in patients with anal fissure. Aliment Pharmacol Ther 2002;16:101–103PubMed Tankova L, Yoncheva K, Muhtarov M, et al. Topical mononitrate treatment in patients with anal fissure. Aliment Pharmacol Ther 2002;16:101–103PubMed
46.
go back to reference Songun I, Boutkan H, Delemarre JBVM, et al. Effect of isosorbide dinitrate ointment on anal fissure. Dig Surg 2003;20:122–126PubMed Songun I, Boutkan H, Delemarre JBVM, et al. Effect of isosorbide dinitrate ointment on anal fissure. Dig Surg 2003;20:122–126PubMed
47.
go back to reference Jost WH, Schimrigk K. Use of botulinum toxin in anal fissure [letter]. Dis Colon Rectum 1993;36:974PubMed Jost WH, Schimrigk K. Use of botulinum toxin in anal fissure [letter]. Dis Colon Rectum 1993;36:974PubMed
48.
49.
go back to reference Jones OM, Brading AF, Mortensen McC. Mechanism of action of botulinum toxin on the internal anal sphincter. Br J Surg 2004;91:224–228PubMed Jones OM, Brading AF, Mortensen McC. Mechanism of action of botulinum toxin on the internal anal sphincter. Br J Surg 2004;91:224–228PubMed
50.
go back to reference Hallan RI, Williams NS, Melling J, et al. Treatment of anismus in intractable constipation with botulinum toxin. Lancet 1988;2:714–717PubMed Hallan RI, Williams NS, Melling J, et al. Treatment of anismus in intractable constipation with botulinum toxin. Lancet 1988;2:714–717PubMed
51.
go back to reference Bhutani MS. Gastrointestinal uses of botulinum toxin. Am J Gastroenterol 1997;92:929–933PubMed Bhutani MS. Gastrointestinal uses of botulinum toxin. Am J Gastroenterol 1997;92:929–933PubMed
52.
go back to reference Maria G, Cassetta E, Gui D, et al. A comparison of botulinum toxin and saline for the treatment of chronic anal fissure. N Engl J Med 1998;338:217–220PubMed Maria G, Cassetta E, Gui D, et al. A comparison of botulinum toxin and saline for the treatment of chronic anal fissure. N Engl J Med 1998;338:217–220PubMed
53.
go back to reference Jost WH, Schimrigk K. Therapy of anal fissure using botulinum toxin. Dis Colon Rectum 1994;37:1321–1324PubMed Jost WH, Schimrigk K. Therapy of anal fissure using botulinum toxin. Dis Colon Rectum 1994;37:1321–1324PubMed
54.
go back to reference Brisinda G, Albanese A, Cadeddu F, et al. Botulinum neurotoxin to treat anal fissure: results of a randomized Botox vs. Dysport controlled trial. Aliment Pharmacol Ther 2004;19:695–701PubMed Brisinda G, Albanese A, Cadeddu F, et al. Botulinum neurotoxin to treat anal fissure: results of a randomized Botox vs. Dysport controlled trial. Aliment Pharmacol Ther 2004;19:695–701PubMed
55.
go back to reference Espi A, Melo F, Mingue M, et al. Therapeutic effects of different doses of botulinum toxin in chronic anal fissure [abstract]. Dis Colon Rectum 1998;41:A16 Espi A, Melo F, Mingue M, et al. Therapeutic effects of different doses of botulinum toxin in chronic anal fissure [abstract]. Dis Colon Rectum 1998;41:A16
56.
go back to reference Maria G, Brisinda G, Bentivoglio AR, et al. Influence of botulinum toxin site of injections on healing rate in patients with chronic anal fissure. Am J Surg 2000;179:46–50PubMed Maria G, Brisinda G, Bentivoglio AR, et al. Influence of botulinum toxin site of injections on healing rate in patients with chronic anal fissure. Am J Surg 2000;179:46–50PubMed
57.
go back to reference Gui D, Cassetta E, Anastasio G, et al. Botulinum toxin for chronic anal fissure. Lancet 1994;344:1127–1128PubMed Gui D, Cassetta E, Anastasio G, et al. Botulinum toxin for chronic anal fissure. Lancet 1994;344:1127–1128PubMed
58.
go back to reference Maria G, Brisinda G, Bentivoglio AR, et al. Botulinum toxin injections in the internal anal sphincter for the treatment of chronic anal fissure: long-term results after two different dose regimens. Ann Surg 1998;228:664–669PubMed Maria G, Brisinda G, Bentivoglio AR, et al. Botulinum toxin injections in the internal anal sphincter for the treatment of chronic anal fissure: long-term results after two different dose regimens. Ann Surg 1998;228:664–669PubMed
59.
go back to reference Brisinda G, Maria G, Bentivoglio AR, et al. A comparison of injections of botulinum toxin and topical nitroglycerine ointment for the treatment of chronic anal fissure. N Engl J Med 1999;341:65–69PubMed Brisinda G, Maria G, Bentivoglio AR, et al. A comparison of injections of botulinum toxin and topical nitroglycerine ointment for the treatment of chronic anal fissure. N Engl J Med 1999;341:65–69PubMed
60.
go back to reference Lysyl J, Isrealit-Yatzkan Y, Sestiery-Ittah M, et al. Topical nitrates potentiate the effects of botulinum toxin in the treatment of patients with refractory anal fissure. Gut 2001;48:221–224 Lysyl J, Isrealit-Yatzkan Y, Sestiery-Ittah M, et al. Topical nitrates potentiate the effects of botulinum toxin in the treatment of patients with refractory anal fissure. Gut 2001;48:221–224
61.
go back to reference Latimer PR, Hodgkins PR, Vakalis AN, et al. Necrotising fasciitis as a complication of botulinum toxin injection. Eye 1998;12:51–53PubMed Latimer PR, Hodgkins PR, Vakalis AN, et al. Necrotising fasciitis as a complication of botulinum toxin injection. Eye 1998;12:51–53PubMed
62.
go back to reference Jost WH. One hundred cases of anal fissure treated with botulinum toxin: early and long term results. Dis Colon Rectum 1997;40:1029–1032PubMed Jost WH. One hundred cases of anal fissure treated with botulinum toxin: early and long term results. Dis Colon Rectum 1997;40:1029–1032PubMed
63.
go back to reference Jost WH, Schanne S, Mlitz H, et al. Perianal thrombosis following injection therapy into the external anal sphincter using botulinum toxin. Dis Colon Rectum 1995;38:781PubMed Jost WH, Schanne S, Mlitz H, et al. Perianal thrombosis following injection therapy into the external anal sphincter using botulinum toxin. Dis Colon Rectum 1995;38:781PubMed
64.
go back to reference Lindsey I, Jones OM, Cunningham C, et al. Botulinum toxin as a second-line therapy for chronic anal fissure failing 0.2 percent glyceryl trinitrate. Dis Colon Rectum 2003;46:361–366PubMed Lindsey I, Jones OM, Cunningham C, et al. Botulinum toxin as a second-line therapy for chronic anal fissure failing 0.2 percent glyceryl trinitrate. Dis Colon Rectum 2003;46:361–366PubMed
65.
go back to reference Jost WH, Mlitz H, Schanne S, Schimrigk K. Botulinum toxin in the treatment of fissure-in-ano. Coloproctology 1995;17:224–229 Jost WH, Mlitz H, Schanne S, Schimrigk K. Botulinum toxin in the treatment of fissure-in-ano. Coloproctology 1995;17:224–229
66.
go back to reference Espi A, Melo F, Minguez M, et al. Therapeutic use of botulinum toxin in anal fissure. Int J Colorectal Dis 1997;12:163 Espi A, Melo F, Minguez M, et al. Therapeutic use of botulinum toxin in anal fissure. Int J Colorectal Dis 1997;12:163
67.
go back to reference Traube M, Dubovik S, Lange RC, et al. The role of nifedipine therapy in achalasia: results of randomized double-blind, placebo-controlled study. Am J Gastroenterol 1989;84:1259–1262PubMed Traube M, Dubovik S, Lange RC, et al. The role of nifedipine therapy in achalasia: results of randomized double-blind, placebo-controlled study. Am J Gastroenterol 1989;84:1259–1262PubMed
68.
go back to reference Coccia G, Bortolotti M, Michetti P, et al. Prospective clinical and manometric study comparing pneumatic dilatation and sublingual nifedipine in the treatment of oesophageal achalasia. Gut 1991;32:604–606PubMed Coccia G, Bortolotti M, Michetti P, et al. Prospective clinical and manometric study comparing pneumatic dilatation and sublingual nifedipine in the treatment of oesophageal achalasia. Gut 1991;32:604–606PubMed
69.
go back to reference Cook TA, Branding AF, Mortensen NJM. Differences in contractile properties of anorectal smooth muscle and the effect of calcium channel blockade. Br J Surg 1999;86:70–75PubMed Cook TA, Branding AF, Mortensen NJM. Differences in contractile properties of anorectal smooth muscle and the effect of calcium channel blockade. Br J Surg 1999;86:70–75PubMed
70.
go back to reference Cook TA, Humphreys MM, Mortensen NJMcC. Oral nifedipine reduces resting anal pressure and heals chronic anal pressure. Br J Surg 1999;86:1269–1273PubMed Cook TA, Humphreys MM, Mortensen NJMcC. Oral nifedipine reduces resting anal pressure and heals chronic anal pressure. Br J Surg 1999;86:1269–1273PubMed
71.
go back to reference Chrysos E, Xynos E, Tzovaras G, et al. Effect of nifedipine on rectoanal motility. Dis Colon Rectum 1996;39:212–216PubMed Chrysos E, Xynos E, Tzovaras G, et al. Effect of nifedipine on rectoanal motility. Dis Colon Rectum 1996;39:212–216PubMed
72.
go back to reference Antropoli C, Perrotti P, Rubino M, et al. Nifedipine for local use in conservative treatment of anal fissures: preliminary results of a multicentre study. Dis Colon Rectum 1999;42:1011–1015PubMed Antropoli C, Perrotti P, Rubino M, et al. Nifedipine for local use in conservative treatment of anal fissures: preliminary results of a multicentre study. Dis Colon Rectum 1999;42:1011–1015PubMed
73.
go back to reference Knight JS, Birks M, Farouk R. Topical diltiazem ointment in the treatment of chronic anal fissure. Br J Surg 2001;88:553–556PubMed Knight JS, Birks M, Farouk R. Topical diltiazem ointment in the treatment of chronic anal fissure. Br J Surg 2001;88:553–556PubMed
74.
go back to reference Carapeti EA, Kamm MA, Phillips RK. Topical diltiazem and bethanechol decrease anal sphincter pressures and heal anal fissure without side effects. Dis Colon Rectum 2000;43:1359–1362PubMed Carapeti EA, Kamm MA, Phillips RK. Topical diltiazem and bethanechol decrease anal sphincter pressures and heal anal fissure without side effects. Dis Colon Rectum 2000;43:1359–1362PubMed
75.
go back to reference Jonard P, Essemri B. Diltiazem and internal anal sphincter. Lancet 1987;1:754PubMed Jonard P, Essemri B. Diltiazem and internal anal sphincter. Lancet 1987;1:754PubMed
76.
go back to reference Carapeti EA, Kamm MA, Evans BK, et al. Diltiazem lowers resting anal sphincter pressure; a potential low side-effect alternative to glyceryl trinitrate for fissures [abstract]. Gut 1998;42:A97CrossRef Carapeti EA, Kamm MA, Evans BK, et al. Diltiazem lowers resting anal sphincter pressure; a potential low side-effect alternative to glyceryl trinitrate for fissures [abstract]. Gut 1998;42:A97CrossRef
77.
go back to reference Jonas M, Neal KR, Abercrombie JF, et al. A randomized trial of oral vs topical diltiazem for chronic anal fissures. Dis Colon Rectum 2001;44:1074–1078PubMed Jonas M, Neal KR, Abercrombie JF, et al. A randomized trial of oral vs topical diltiazem for chronic anal fissures. Dis Colon Rectum 2001;44:1074–1078PubMed
78.
go back to reference DasGupta R, Franklin I, Pitt I, et al. Successful treatment of chronic anal fissure with diltiazem gel. Colorectal Dis 2002;4:20–22PubMed DasGupta R, Franklin I, Pitt I, et al. Successful treatment of chronic anal fissure with diltiazem gel. Colorectal Dis 2002;4:20–22PubMed
79.
go back to reference Kocher HM, Steward M, Leather AJM, et al. Randomized clinical trial assessing the side-effects of glyceryl trinitrate and diltiazem hydrochloride in the treatment of chronic anal fissure. Br J Surg 2002;89:413–417PubMed Kocher HM, Steward M, Leather AJM, et al. Randomized clinical trial assessing the side-effects of glyceryl trinitrate and diltiazem hydrochloride in the treatment of chronic anal fissure. Br J Surg 2002;89:413–417PubMed
80.
go back to reference Bielecki K, Kolodziejczak M. A prospective randomized trial diltiazem and glyceryl trinitrate ointment in the treatment of chronic anal fissure. Colorectal Dis 2003;5:256–257PubMed Bielecki K, Kolodziejczak M. A prospective randomized trial diltiazem and glyceryl trinitrate ointment in the treatment of chronic anal fissure. Colorectal Dis 2003;5:256–257PubMed
81.
go back to reference Ezri T, Susmalliam S. Topical nifedipine vs. topical glyceryl trinitrate of chronic anal fissure. Dis Colon Rectum 2003;46:805–808PubMed Ezri T, Susmalliam S. Topical nifedipine vs. topical glyceryl trinitrate of chronic anal fissure. Dis Colon Rectum 2003;46:805–808PubMed
82.
go back to reference Carapeti EA, Kamm MA, Evans BK, et al. Topical diltiazem and bethanechol decrease anal sphincter pressure without side effects. Gut 1999;45:719–722PubMedCrossRef Carapeti EA, Kamm MA, Evans BK, et al. Topical diltiazem and bethanechol decrease anal sphincter pressure without side effects. Gut 1999;45:719–722PubMedCrossRef
83.
go back to reference Pitt J, Craggs MD, Henry MM, et al. Alpha-1 adrenoceptor blockade: potential new treatment for anal fissures. Dis Colon Rectum 2000;43:800–803PubMed Pitt J, Craggs MD, Henry MM, et al. Alpha-1 adrenoceptor blockade: potential new treatment for anal fissures. Dis Colon Rectum 2000;43:800–803PubMed
84.
go back to reference Pitt J, Dawson PM, Hallam RI, et al. A double-blind randomized placebo-controlled trial of oral indoramin to treat chronic anal fissure. Colorectal Dis 2001;3:165–168PubMed Pitt J, Dawson PM, Hallam RI, et al. A double-blind randomized placebo-controlled trial of oral indoramin to treat chronic anal fissure. Colorectal Dis 2001;3:165–168PubMed
85.
go back to reference Lord PH. A new regime for the treatment of heamorrhoids. Proc R Soc Med 1960;61:935–936 Lord PH. A new regime for the treatment of heamorrhoids. Proc R Soc Med 1960;61:935–936
86.
go back to reference Weaver RM, Ambrose NS, Alexander-Williams J, et al. Manual dilatation of the anus vs internal subcutaneous sphincterotomy in the treatment of chronic fissure in ano: results of a prospective, randomized, clinical trial. Dis Colon Rectum 1987;30:420–423PubMed Weaver RM, Ambrose NS, Alexander-Williams J, et al. Manual dilatation of the anus vs internal subcutaneous sphincterotomy in the treatment of chronic fissure in ano: results of a prospective, randomized, clinical trial. Dis Colon Rectum 1987;30:420–423PubMed
87.
go back to reference Lestar B, Penninckx F, Kerremans R. Anal dilatation. Int J Colorectal Dis 1987;2:167–168PubMed Lestar B, Penninckx F, Kerremans R. Anal dilatation. Int J Colorectal Dis 1987;2:167–168PubMed
88.
go back to reference Sohn N, Eisenberg MM, Weinstein MA, et al. Precise anorectal sphincter dilatation: its role in the therapy of anal fissures. Dis Colon Rectum 1992;35:322–327PubMed Sohn N, Eisenberg MM, Weinstein MA, et al. Precise anorectal sphincter dilatation: its role in the therapy of anal fissures. Dis Colon Rectum 1992;35:322–327PubMed
89.
go back to reference Boschetto S, Giovannone M, Tosnoni M, et al. Hydropneumatic anal dilatation in conservative treatment of chronic anal fissure: clinical outcomes and randomized comparison with topical nitroglycerin. Tech Coloproctol 2004;8:89–93PubMed Boschetto S, Giovannone M, Tosnoni M, et al. Hydropneumatic anal dilatation in conservative treatment of chronic anal fissure: clinical outcomes and randomized comparison with topical nitroglycerin. Tech Coloproctol 2004;8:89–93PubMed
90.
go back to reference Speakman CTM, Burnett SJD, Kamm MA, et al. Sphincter injury after anal dilatation demonstrated by anal endosonography. Br J Surg 1991;78:1429—1430PubMed Speakman CTM, Burnett SJD, Kamm MA, et al. Sphincter injury after anal dilatation demonstrated by anal endosonography. Br J Surg 1991;78:1429—1430PubMed
91.
go back to reference Snooks S, Henry MM, Swash M. Faecal incontinence after anal dilatation. Br J Surg 1984;71:617–618PubMed Snooks S, Henry MM, Swash M. Faecal incontinence after anal dilatation. Br J Surg 1984;71:617–618PubMed
92.
go back to reference Nielsen MB, Rasmussen OO, Pedersen JF, et al. Risk of sphincter damage and anal incontinence after anal dilatation for fissure in ano: an endosonographic study. Dis Colon Rectum 1983;36:677–680 Nielsen MB, Rasmussen OO, Pedersen JF, et al. Risk of sphincter damage and anal incontinence after anal dilatation for fissure in ano: an endosonographic study. Dis Colon Rectum 1983;36:677–680
93.
go back to reference MacDonald A, Smith A, McNeill AD, et al. Manual dilatation of the anus. Br J Surg 1992;79:1381–1382PubMed MacDonald A, Smith A, McNeill AD, et al. Manual dilatation of the anus. Br J Surg 1992;79:1381–1382PubMed
94.
go back to reference Jensen SL, Lund F, Nielsen OV, et al. Lateral subcutaneous sphincterotomy vs versus anal dilatation in the treatment of fissure in ano in outpatients: a prospective randomized study. BMJ 1984;289:528–530PubMedCrossRef Jensen SL, Lund F, Nielsen OV, et al. Lateral subcutaneous sphincterotomy vs versus anal dilatation in the treatment of fissure in ano in outpatients: a prospective randomized study. BMJ 1984;289:528–530PubMedCrossRef
95.
go back to reference Saad AM, Omer A. Surgical treatment of chronic fissure in ano: a prospective randomized study. East Afr Med J 1992;69:613–615PubMed Saad AM, Omer A. Surgical treatment of chronic fissure in ano: a prospective randomized study. East Afr Med J 1992;69:613–615PubMed
96.
go back to reference Collopy B, Ryan P. Comparison of lateral subcutaneous sphincterotomy with anal dilatation in the treatment of fissure in ano. Med J Aust 1979;2:461–462, 487PubMed Collopy B, Ryan P. Comparison of lateral subcutaneous sphincterotomy with anal dilatation in the treatment of fissure in ano. Med J Aust 1979;2:461–462, 487PubMed
98.
go back to reference Strugnell NA, Cooke SG Lucarotti ME, et al. Controlled digital anal dilatation under total neuromuscular blockade for chronic anal fissure: a justifiable procedure. Br J Surg 1999;86:651–655PubMed Strugnell NA, Cooke SG Lucarotti ME, et al. Controlled digital anal dilatation under total neuromuscular blockade for chronic anal fissure: a justifiable procedure. Br J Surg 1999;86:651–655PubMed
99.
go back to reference Abcarian H. Surgical correction of chronic anal fissure: results of lateral internal sphincterotomy vs fissurectomy-midline sphincterotomy. Dis Colon Rectum 1980;23:31–36PubMed Abcarian H. Surgical correction of chronic anal fissure: results of lateral internal sphincterotomy vs fissurectomy-midline sphincterotomy. Dis Colon Rectum 1980;23:31–36PubMed
100.
go back to reference Abcarian H, Lakshamanan S, Read DR, et al. The role of internal sphincter in chronic anal fissures. Dis Colon Rectum 1982;25:525–528PubMed Abcarian H, Lakshamanan S, Read DR, et al. The role of internal sphincter in chronic anal fissures. Dis Colon Rectum 1982;25:525–528PubMed
101.
go back to reference Bailey R, Rubin RJ, Salvati EP. Lateral internal sphincterotomy. Dis Colon Rectum 1978;21:584–586PubMed Bailey R, Rubin RJ, Salvati EP. Lateral internal sphincterotomy. Dis Colon Rectum 1978;21:584–586PubMed
102.
go back to reference Brown SR, Taylor A, Adam IJ, et al. The management of persistent and recurrent chronic anal fissures. Colorectal Dis 2002;4:226–232PubMed Brown SR, Taylor A, Adam IJ, et al. The management of persistent and recurrent chronic anal fissures. Colorectal Dis 2002;4:226–232PubMed
103.
go back to reference Argov S, Levandovsky O. Open lateral sphincterotomy is still the best treatment for chronic anal fissure. Am J Surg 2000;197:201–202 Argov S, Levandovsky O. Open lateral sphincterotomy is still the best treatment for chronic anal fissure. Am J Surg 2000;197:201–202
104.
go back to reference Pernikoff BJ, Eisenstat TE, Rubin RJ, et al. Reappraisal of partial lateral internal sphincterotomy. Dis Colon Rectum 1994;37:1201–1205 Pernikoff BJ, Eisenstat TE, Rubin RJ, et al. Reappraisal of partial lateral internal sphincterotomy. Dis Colon Rectum 1994;37:1201–1205
105.
go back to reference Garcia-Aguilar J, Belmonte C, Wong D, et al. Open vs closed sphincterotomy for chronic anal fissure. Dis Colon Rectum 1996;39:440–443PubMed Garcia-Aguilar J, Belmonte C, Wong D, et al. Open vs closed sphincterotomy for chronic anal fissure. Dis Colon Rectum 1996;39:440–443PubMed
106.
go back to reference Boulos PB, Araujo JG. Adequate internal sphincterotomy for chronic anal fissure: subcutaneous or open technique? Br J Surg 1984;71:360–362PubMed Boulos PB, Araujo JG. Adequate internal sphincterotomy for chronic anal fissure: subcutaneous or open technique? Br J Surg 1984;71:360–362PubMed
107.
go back to reference Garcia-Aguilar J, Belmonte Montes C, Perez JJ, et al. Incontinence after lateral internal sphincterotomy: anatomic and functional evaluation. Dis Colon Rectum 1998;41:423–427PubMed Garcia-Aguilar J, Belmonte Montes C, Perez JJ, et al. Incontinence after lateral internal sphincterotomy: anatomic and functional evaluation. Dis Colon Rectum 1998;41:423–427PubMed
108.
go back to reference Kortbeek JB, Langevin JR, Khoo RE, et al. Chronic fissure in ano: a randomized study comparing open and subcutaneous lateral internal sphincterotomy. Dis Colon Rectum 1992;35:835–837PubMed Kortbeek JB, Langevin JR, Khoo RE, et al. Chronic fissure in ano: a randomized study comparing open and subcutaneous lateral internal sphincterotomy. Dis Colon Rectum 1992;35:835–837PubMed
109.
go back to reference Lewis TH, Corman ML, Prager ED, Robertson WG. Long-term results of open and closed sphincterotomy for anal fissure. Dis Colon Rectum 1988;31:368–371PubMed Lewis TH, Corman ML, Prager ED, Robertson WG. Long-term results of open and closed sphincterotomy for anal fissure. Dis Colon Rectum 1988;31:368–371PubMed
110.
go back to reference Keighley MR, Greca F, Nevah E, et al. Treatment of anal fissure by lateral subcutaneous sphincterotomy should be under general anaesthesia. Br J Surg 1981;68:400–401PubMed Keighley MR, Greca F, Nevah E, et al. Treatment of anal fissure by lateral subcutaneous sphincterotomy should be under general anaesthesia. Br J Surg 1981;68:400–401PubMed
111.
go back to reference Olsen J, Mortensen PE, Krogh Petersen I, et al. Anal sphincter function after treatment of fissure in ano by lateral subcutaneous sphincterotomy versus anal dilatation: a randomized study. Int J Colorectal Dis 1987;2:155–157PubMed Olsen J, Mortensen PE, Krogh Petersen I, et al. Anal sphincter function after treatment of fissure in ano by lateral subcutaneous sphincterotomy versus anal dilatation: a randomized study. Int J Colorectal Dis 1987;2:155–157PubMed
112.
go back to reference Garcea G, Sutton C, Mansoori S, et al. Results following conservative lateral sphincterotomy for the treatment of chronic anal fissures. Colorectal Dis 2003;5:311–314PubMed Garcea G, Sutton C, Mansoori S, et al. Results following conservative lateral sphincterotomy for the treatment of chronic anal fissures. Colorectal Dis 2003;5:311–314PubMed
113.
go back to reference Sultan AH, Kamm MA, Nicholls RJ, et al. Prospective study of the extent of internal anal sphincter division during lateral sphincterotomy. Dis Colon Rectum 1994;37:1031–1033PubMed Sultan AH, Kamm MA, Nicholls RJ, et al. Prospective study of the extent of internal anal sphincter division during lateral sphincterotomy. Dis Colon Rectum 1994;37:1031–1033PubMed
114.
go back to reference Nivatvongs S, Stern HS, Fryd DS. The length of anal canal. Dis Colon Rectum 1981;24:600–601PubMed Nivatvongs S, Stern HS, Fryd DS. The length of anal canal. Dis Colon Rectum 1981;24:600–601PubMed
115.
go back to reference Richard CS, Gregoire R, Plewes AE, et al. Internal sphincterotomy is superior to topical nitroglycerine in the treatment of chronic anal fissure: results of a randomized controlled trial by the Canadian Colorectal Surgical Trials Group. Dis Colon Rectum 2000;43:1048–1057PubMed Richard CS, Gregoire R, Plewes AE, et al. Internal sphincterotomy is superior to topical nitroglycerine in the treatment of chronic anal fissure: results of a randomized controlled trial by the Canadian Colorectal Surgical Trials Group. Dis Colon Rectum 2000;43:1048–1057PubMed
116.
go back to reference Oettle GJ. Glyceryl trinitrate vs sphincterotomy for treatment of chronic fissure in ano: a randomized, controlled trial. Dis Colon Rectum 1997;40:1318–1320PubMed Oettle GJ. Glyceryl trinitrate vs sphincterotomy for treatment of chronic fissure in ano: a randomized, controlled trial. Dis Colon Rectum 1997;40:1318–1320PubMed
117.
go back to reference Tocchi A, Mazzoni G, Miccini M, et al. Total lateral sphincterotomy for anal fissure. Int J Colorectal Dis 2004;19:245–249PubMed Tocchi A, Mazzoni G, Miccini M, et al. Total lateral sphincterotomy for anal fissure. Int J Colorectal Dis 2004;19:245–249PubMed
118.
go back to reference Hyman N. Incontinence after lateral internal sphincterotomy: a prospective study and quality of life assessment. Dis Colon Rectum 2004;47:35–38PubMed Hyman N. Incontinence after lateral internal sphincterotomy: a prospective study and quality of life assessment. Dis Colon Rectum 2004;47:35–38PubMed
119.
go back to reference Wiley M, Day P, Rieger N, Stephens J, et al. Open vs. closed lateral internal sphincterotomy for idiopathic fissure-in-ano: a prospective, randomized, controlled trial. Dis Colon Rectum 2004;47:847–852PubMed Wiley M, Day P, Rieger N, Stephens J, et al. Open vs. closed lateral internal sphincterotomy for idiopathic fissure-in-ano: a prospective, randomized, controlled trial. Dis Colon Rectum 2004;47:847–852PubMed
120.
go back to reference Arroyo A, Perez F, Serrano P, et al. Open versus closed lateral sphincterotomy performed as an outpatient procedure under local anaesthesia for chronic anal fissure: prospective randomized study of clinical and manometric longterm results. J Am Coll Surg 2004;199:361–367PubMed Arroyo A, Perez F, Serrano P, et al. Open versus closed lateral sphincterotomy performed as an outpatient procedure under local anaesthesia for chronic anal fissure: prospective randomized study of clinical and manometric longterm results. J Am Coll Surg 2004;199:361–367PubMed
121.
go back to reference Ellis CN. Anterior levatorplasty for the treatment of chronic anal fissures in females with a rectocele: a randomized, control trial. Dis Colon Rectum 2004;47:1170–1173PubMed Ellis CN. Anterior levatorplasty for the treatment of chronic anal fissures in females with a rectocele: a randomized, control trial. Dis Colon Rectum 2004;47:1170–1173PubMed
122.
go back to reference Mentes BB, Irkorucu O, Akin M, et al. Comparison of botulinum toxin injection and lateral internal sphincterotomy for the treatment of chronic anal fissure. Dis Colon Rectum 2003;46:1144–1147 Mentes BB, Irkorucu O, Akin M, et al. Comparison of botulinum toxin injection and lateral internal sphincterotomy for the treatment of chronic anal fissure. Dis Colon Rectum 2003;46:1144–1147
123.
go back to reference Giral A, Memisoglu K, Gultekin Y, et al. Botulinum toxin injection versus lateral internal sphincterotomy in the treatment of chronic anal fissure: a non-randomized controlled trial. BMC Gastroenterol 2004;4:7PubMed Giral A, Memisoglu K, Gultekin Y, et al. Botulinum toxin injection versus lateral internal sphincterotomy in the treatment of chronic anal fissure: a non-randomized controlled trial. BMC Gastroenterol 2004;4:7PubMed
124.
go back to reference Lindsey I, Cunningham C, Jones OM, et al. Fissurectomy-botulinum toxin: a novel sphincter-sparing procedure for medically resistant chronic anal fissure. Dis Colon Rectum 2004;47:1947–1952PubMed Lindsey I, Cunningham C, Jones OM, et al. Fissurectomy-botulinum toxin: a novel sphincter-sparing procedure for medically resistant chronic anal fissure. Dis Colon Rectum 2004;47:1947–1952PubMed
125.
go back to reference Evans J, Luck A, Hewett P. Glyceryl trinitrate vs. lateral sphincterotomy for chronic anal fissure: prospective, randomized trial. Dis Colon Rectum 2001;44:93–97PubMed Evans J, Luck A, Hewett P. Glyceryl trinitrate vs. lateral sphincterotomy for chronic anal fissure: prospective, randomized trial. Dis Colon Rectum 2001;44:93–97PubMed
126.
go back to reference Libertiny G, Knight JS, Farouk R. Randomized trial of topical glyceryl trinitrate and lateral internal sphincterotomy for the treatment of patients with chronic anal fissure. Eur J Surg 2002;168:418–421PubMed Libertiny G, Knight JS, Farouk R. Randomized trial of topical glyceryl trinitrate and lateral internal sphincterotomy for the treatment of patients with chronic anal fissure. Eur J Surg 2002;168:418–421PubMed
127.
go back to reference Parellada C. Randomized, prospective trial comparing 0.2 percent isosorbide dinitrate ointment with sphincterotomy in treatment of chronic anal fissure: a two-year follow-up. Dis Colon Rectum 2004;47:437–443PubMed Parellada C. Randomized, prospective trial comparing 0.2 percent isosorbide dinitrate ointment with sphincterotomy in treatment of chronic anal fissure: a two-year follow-up. Dis Colon Rectum 2004;47:437–443PubMed
128.
go back to reference Engel AF, Eijsbouts QAJ, Balk AG. Fissurectomy and isosorbide dinitrate for chronic fissure-in-ano not responding to conservative treatment. Br J Surg 2002;89:79–83PubMed Engel AF, Eijsbouts QAJ, Balk AG. Fissurectomy and isosorbide dinitrate for chronic fissure-in-ano not responding to conservative treatment. Br J Surg 2002;89:79–83PubMed
129.
go back to reference Lambe GF, Driver CP, Morton S, et al. Fissurectomy as a treatment for anal fissures in children. Ann R Coll Surg Engl 2000;82:254–257PubMed Lambe GF, Driver CP, Morton S, et al. Fissurectomy as a treatment for anal fissures in children. Ann R Coll Surg Engl 2000;82:254–257PubMed
130.
go back to reference Kenefick NJ, Gee AS, Durdey P. Treatment of resistant anal fissure with advancement anoplasty. Colorectal Dis 2002;4:463–466PubMed Kenefick NJ, Gee AS, Durdey P. Treatment of resistant anal fissure with advancement anoplasty. Colorectal Dis 2002;4:463–466PubMed
131.
go back to reference Nyam DCNK, Wilson RG, Stewart KJ, et al. Island advancement flaps in the management of anal fissures. Br J Surg 1995;38:69–71 Nyam DCNK, Wilson RG, Stewart KJ, et al. Island advancement flaps in the management of anal fissures. Br J Surg 1995;38:69–71
132.
go back to reference Leong AF, Seow-Choen F. Lateral sphincterotomy compared with anal advancement flap for chronic anal fissure. Dis Colon Rectum 1995;38:69–71PubMed Leong AF, Seow-Choen F. Lateral sphincterotomy compared with anal advancement flap for chronic anal fissure. Dis Colon Rectum 1995;38:69–71PubMed
133.
go back to reference Sweeney JL, Ritchie JK, Nicholls RJ. Anal fissure in Crohn’s disease. Br J Surg 1988;75:56–57PubMed Sweeney JL, Ritchie JK, Nicholls RJ. Anal fissure in Crohn’s disease. Br J Surg 1988;75:56–57PubMed
134.
go back to reference Fleshner PR, Schoetz DJ Jr, Poberts PL, et al. Anal fissure in Crohn’s disease: a plea for aggressive management. Dis Colon Rectum 1995;38:1137–1143PubMed Fleshner PR, Schoetz DJ Jr, Poberts PL, et al. Anal fissure in Crohn’s disease: a plea for aggressive management. Dis Colon Rectum 1995;38:1137–1143PubMed
135.
go back to reference Miles AJ, Mellor CH, Gazzard B, et al. Surgical management of anorectal disease in HIV-positive homosexuals. Br J Surg 1999;77:869–871 Miles AJ, Mellor CH, Gazzard B, et al. Surgical management of anorectal disease in HIV-positive homosexuals. Br J Surg 1999;77:869–871
136.
go back to reference Scholefield JH, Northover JMA, Carr MD. Male homosexually HIV infection and colorectal surgery. Br J Surg 1990;77:493–496PubMed Scholefield JH, Northover JMA, Carr MD. Male homosexually HIV infection and colorectal surgery. Br J Surg 1990;77:493–496PubMed
137.
go back to reference Wexner SD. Sexually transmitted diseases of the colon and anus: the challenge of the nineties. Dis Colon Rectum 1990;33:1048–1062PubMed Wexner SD. Sexually transmitted diseases of the colon and anus: the challenge of the nineties. Dis Colon Rectum 1990;33:1048–1062PubMed
138.
go back to reference Wexner SD, Smithy WB, Milson JW, et al. The surgical management of anorectal diseases in AIDS and pre-AIDS patients. Dis Colon Rectum 1986;29:719–723PubMed Wexner SD, Smithy WB, Milson JW, et al. The surgical management of anorectal diseases in AIDS and pre-AIDS patients. Dis Colon Rectum 1986;29:719–723PubMed
139.
go back to reference Nadal SR, Manzione CR, Galvao VM, et al. Perianal diseases in HIV positive patients compared with a seronegative population. Dis Colon Rectum 1999;42:649–654PubMed Nadal SR, Manzione CR, Galvao VM, et al. Perianal diseases in HIV positive patients compared with a seronegative population. Dis Colon Rectum 1999;42:649–654PubMed
140.
go back to reference Barrett WL, Callahan TD, Orkin BA. Perianal manifestations of human immunodeficiency virus infection: experience in 260 patients. Dis Colon Rectum 1998;41:606–612PubMed Barrett WL, Callahan TD, Orkin BA. Perianal manifestations of human immunodeficiency virus infection: experience in 260 patients. Dis Colon Rectum 1998;41:606–612PubMed
141.
go back to reference Safari A, Gottesman L Dailey TH. Anorectal surgery in the HIV-positive patients: update. Dis Colon Rectum 1991;34:299–304 Safari A, Gottesman L Dailey TH. Anorectal surgery in the HIV-positive patients: update. Dis Colon Rectum 1991;34:299–304
142.
go back to reference Miles AJG, Connolly GM, Barton SE, et al. Persistent ulceration of the anal margin in homosexuals with HIV infection. J R Soc Med 1991;84:87–88PubMed Miles AJG, Connolly GM, Barton SE, et al. Persistent ulceration of the anal margin in homosexuals with HIV infection. J R Soc Med 1991;84:87–88PubMed
143.
go back to reference Goodell SE, Quinn TC, Mkrtichian EE, et al. Herpes simplex virus: an important cause of acute proctitis in homosexual men. Gastroenterology 1981;80:1159 Goodell SE, Quinn TC, Mkrtichian EE, et al. Herpes simplex virus: an important cause of acute proctitis in homosexual men. Gastroenterology 1981;80:1159
144.
go back to reference Consten ECJ, Slors JFM, Danner SA, et al. Local excision and mucosal advancement for anal ulceration in patients infected with human immunodeficiency virus. Br J Surg 1995;82:891–894PubMed Consten ECJ, Slors JFM, Danner SA, et al. Local excision and mucosal advancement for anal ulceration in patients infected with human immunodeficiency virus. Br J Surg 1995;82:891–894PubMed
145.
go back to reference Candela F, Serrano P, Arriero JM, et al. Perianal disease of tuberculous origin: report of a case and review of literature. Dis Colon Rectum 1999;42:110–112.PubMed Candela F, Serrano P, Arriero JM, et al. Perianal disease of tuberculous origin: report of a case and review of literature. Dis Colon Rectum 1999;42:110–112.PubMed
146.
go back to reference Whalen TV Jr, Kovalcik PJ, Old WL Jr. Tuberculous anal ulcer. Dis Colon Rectum 1980;23:545 Whalen TV Jr, Kovalcik PJ, Old WL Jr. Tuberculous anal ulcer. Dis Colon Rectum 1980;23:545
147.
go back to reference Smith DL, Cataldo PA. Perianal lymphoma in a heterosexual and non-immunocompromised patient: report of a case and review of literature. Dis Colon Rectum 1999;42:952–954PubMed Smith DL, Cataldo PA. Perianal lymphoma in a heterosexual and non-immunocompromised patient: report of a case and review of literature. Dis Colon Rectum 1999;42:952–954PubMed
Metadata
Title
Current Concepts in Anal Fissures
Authors
Abraham A. Ayantunde, FRCS, FWACS
Samuel A. Debrah, FRCS, FWACS
Publication date
01-12-2006
Publisher
Springer-Verlag
Published in
World Journal of Surgery / Issue 12/2006
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI
https://doi.org/10.1007/s00268-005-0664-y

Other articles of this Issue 12/2006

World Journal of Surgery 12/2006 Go to the issue