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01-10-2021 | Injectable Filler | Review

Tissue Fillers for the Nasolabial Fold Area: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Authors: Tomasz Stefura, Artur Kacprzyk, Jakub Droś, Marta Krzysztofik, Oksana Skomarovska, Marta Fijałkowska, Mateusz Koziej

Published in: Aesthetic Plastic Surgery | Issue 5/2021

Abstract

Tissue fillers injections remain to be one of the most commonly performed cosmetic procedures. The aim of this meta-analysis was to systematize and present available data on the aesthetic outcomes and safety of treating the nasolabial fold area with tissue fillers. We conducted a systematic review of randomized clinical trials that report outcomes concerning treatment of nasolabial fold area with tissue fillers. We searched the MEDLINE/PubMed, ScienceDirect, EMBASE, BIOSIS, SciELO, Scopus, Cochrane Controlled Register of Trials, CNKI and Web of Science databases. Primary outcomes included aesthetic improvement measured using the Wrinkle Severity Rating Scale score and Global Aesthetic Improvement Scale. Secondary outcomes were incidence rates of complications occurring after the procedure. At baseline, the pooled mean WSRS score was 3.23 (95% CI: 3.20–3.26). One month after the procedure, the pooled WSRS score had reached 1.79 (95% CI: 1.74–1.83). After six months it was 2.02 (95% CI: 1.99–2.05) and after 12 months it was 2.46 (95% CI: 2.4–2.52). One month after the procedure, the pooled GAIS score had reached 2.21 (95% CI: 2.14–2.28). After six months, it was 2.32 (95% CI: 2.26–2.37), and after 12 months, it was 1.27 (95% CI: 1.12–1.42). Overall, the pooled incidence of all complications was 0.58 (95% CI: 0.46–0.7). Most common included lumpiness (43%), tenderness (41%), swelling (34%) and bruising (29%). Tissue fillers used for nasolabial fold area treatment allow achieving a satisfying and sustainable improvement. Most common complications include tenderness, lumpiness, swelling, and bruising.

Level of Evidence II

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Shin J-W, Kwon S-H, Choi J-Y et al (2019) Molecular mechanisms of dermal aging and antiaging approaches. Int J Mol Sci. https://doi.org/10.3390/ijms20092126CrossRefPubMedPubMedCentral

Han A, Chien AL, Kang S (2014) Photoaging. Dermatol Clin 32:291–299. https://doi.org/10.1016/j.det.2014.03.015CrossRefPubMed

Ganceviciene R, Liakou AI, Theodoridis A et al (2012) Skin anti-aging strategies. Dermatoendocrinol 4:308–319. https://doi.org/10.4161/derm.22804CrossRefPubMedPubMedCentral

Arsiwala SZ (2015) Current trends in facial rejuvenation with fillers. J Cutan Aesthet Surg 8:125–126. https://doi.org/10.4103/0974-2077.167261CrossRefPubMedPubMedCentral

Vedamurthy M, Vedamurthy A (2008) Dermal fillers: tips to achieve successful outcomes. J Cutan Aesthet Surg 1:64–67. https://doi.org/10.4103/0974-2077.44161CrossRefPubMedPubMedCentral

Dayan SH, Bassichis BA (2008) Facial dermal fillers: selection of appropriate products and techniques. Aesthetic Surg J 28:335–347. https://doi.org/10.1016/j.asj.2008.03.004CrossRef

Lee W, Hwang S-G, Oh W et al (2020) Practical guidelines for hyaluronic acid soft-tissue filler use in facial rejuvenation. Dermatologic Surg Off Publ Am Soc Dermatologic Surg 46:41–49. https://doi.org/10.1097/DSS.0000000000001858CrossRef

Pogrel MA, Shariati S, Schmidt B et al (1998) The surgical anatomy of the nasolabial fold. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 86:410–415. https://doi.org/10.1016/S1079-2104(98)90365-1CrossRefPubMed

Swanson JA, Schmitz D, Chung KC (2010) How to practice evidence-based medicine. Plast Reconstr Surg 126:286–294. https://doi.org/10.1097/PRS.0b013e3181dc54eeCrossRefPubMedPubMedCentral

10.

Small K, Brandon E, Spinelli HM (2014) Evidence-based medicine in aesthetic medicine and surgery: Reality or fantasy? Aesthetic Plast Surg 38:1151–1155. https://doi.org/10.1007/s00266-014-0378-3CrossRefPubMed

11.

Moher D, Liberati A, Tetzlaff J, Altman DG (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 6:e1000097. https://doi.org/10.1371/journal.pmed.1000097CrossRefPubMedPubMedCentral

12.

Ma J, Liu W, Hunter A, Zhang W (2008) Performing meta-analysis with incomplete statistical information in clinical trials. BMC Med Res Methodol 8:56. https://doi.org/10.1186/1471-2288-8-56CrossRefPubMedPubMedCentral

13.

Higgins JPT, Green S (2011) Cochrane handbook for systematic reviews of interventions. Wiley

14.

Ahn JY, Lee SH, Park KY et al (2012) Clinical comparison of two hyaluronic acid-derived fillers in the treatment of nasolabial folds: Mesoglow ® and IAL System ®. Int J Dermatol 51:601–608. https://doi.org/10.1111/j.1365-4632.2011.05347.xCrossRefPubMed

15.

Baumann L, Weiss RA, Grekin S et al (2018) Comparison of hyaluronic acid gel With (HARDL) and without lidocaine (HAJUP) in the treatment of moderate-to-severe nasolabial folds: a randomized, evaluator-blinded study. Dermatol Surg 44:833–840. https://doi.org/10.1097/DSS.0000000000001424CrossRefPubMed

16.

Galadari H, van Abel D, Al Nuami K et al (2015) A randomized, prospective, blinded, split-face, single-center study comparing polycaprolactone to hyaluronic acid for treatment of nasolabial folds. J Cosmet Dermatol 14:27–32. https://doi.org/10.1111/jocd.12126CrossRefPubMed

17.

Gold MH, Baumann LS, Clark CP, Schlessinger J (2018) A multicenter, double-blinded, randomized, split-face study of the safety and efficacy of a novel hyaluronic acid gel for the correction of nasolabial folds. J Drugs Dermatol 17:66–73PubMed

18.

Grimes PE, Thomas JA, Murphy DK (2009) Safety and effectiveness of hyaluronic acid fillers in skin of color. J Cosmet Dermatol 8:162–168. https://doi.org/10.1111/j.1473-2165.2009.00457.xCrossRefPubMed

19.

Hedén P, Fagrell D, Jernbeck J et al (2010) Injection of stabilized hyaluronic acid-based gel of non-animal origin for the correction of nasolabial folds: comparison with and without lidocaine. Dermatol Surg 36:775–781. https://doi.org/10.1111/j.1524-4725.2010.01544.xCrossRef

20.

Hong JY, Choi EJ, Choi SY et al (2018) Randomized, patient/evaluator-blinded, intraindividual comparison study to evaluate the efficacy and safety of a novel hyaluronic acid dermal filler in the treatment of nasolabial folds. Dermatol Surg 44:542–548. https://doi.org/10.1097/DSS.0000000000001335CrossRefPubMed

21.

Hu X, Xue Z, Qi H, Chen B (2017) Comparative study of autologous fat vs hyaluronic acid in correction of the nasolabial folds. J Cosmet Dermatol 16:e1–e8. https://doi.org/10.1111/jocd.12333CrossRefPubMed

22.

Hyun MY, Lee Y, No YA et al (2015) Efficacy and safety of injection with poly-L-lactic acid compared with hyaluronic acid for correction of nasolabial fold: a randomized, evaluator-blinded, comparative study. Clin Exp Dermatol 40:129–135. https://doi.org/10.1111/ced.12499CrossRefPubMed

23.

Joo HJ, Kang H (2016) A randomized clinical trial to evaluate the efficacy and safety of lidocaine-containing monophasic hyaluronic acid filler for nasolabial folds. Plast Reconstr Surg 137:799–808CrossRefPubMed

24.

Kim BW, Moon IJ, Yun WJ et al (2016) A randomized, evaluator-blinded, split-face comparison study of the efficacy and safety of a novel mannitol containing monophasic hyaluronic acid dermal filler for the treatment of moderate to severe nasolabial folds. Ann Dermatol 28:297–303. https://doi.org/10.5021/ad.2016.28.3.297CrossRefPubMedPubMedCentral

25.

Lee JH, Choi YS, Kim SM et al (2014) Efficacy and safety of porcine collagen filler for nasolabial fold correction in Asians: a prospective multicenter, 12 months follow-up study. J Korean Med Sci 29:S217–S221. https://doi.org/10.3346/jkms.2014.29.S3.S217CrossRefPubMedPubMedCentral

26.

Beer K (2007) A randomized, evaluator-blinded comparison of efficacy of hyaluronic acid gel and avian-sourced hylan B plus gel for correction of nasolabial folds. Dermatologic Surg 33:928–936. https://doi.org/10.1111/j.1524-4725.2007.33194.xCrossRef

27.

Levy PM, De Boulle K, Raspaldo H (2009) A split-face comparison of a new hyaluronic acid facial filler containing pre-incorporated lidocaine versus a standard hyaluronic acid facial filler in the treatment of naso-labial folds. J Cosmet Laser Ther 11:169–173. https://doi.org/10.1080/14764170902833142CrossRefPubMed

28.

Lindqvist C, Tveten S, Bondevik BE, Fagrell D (2005) A randomized, evaluator-blind, multicenter comparison of the efficacy and tolerability of Perlane versus Zyplast in the correction of nasolabial folds. Plast Reconstr Surg 115:282–289. https://doi.org/10.1097/01.PRS.0000146704.02347.36CrossRefPubMed

29.

Lupo MP, Smith SR, Thomas JA et al (2008) Effectiveness of Juvéderm Ultra Plus dermal filler in the treatment of severe nasolabial folds. Plast Reconstr Surg 121:289–297. https://doi.org/10.1097/01.prs.0000294968.76862.83CrossRefPubMed

30.

Marmur E, Green L, Busso M (2010) Controlled, randomized study of pain levels in subjects treated with calcium hydroxylapatite premixed with lidocaine for correction of nasolabial folds. Dermatol Surg 36:309–315. https://doi.org/10.1111/j.1524-4725.2009.01435.xCrossRefPubMed

31.

Moers-Carpi MM, Tufet JO (2008) Calcium hydroxylapatite versus nonanimal stabilized hyaluronic acid for the correction of nasolabial folds: a 12-month, multicenter, prospective, randomized, controlled, split-face trial. Dermatol Surg 34:210–215. https://doi.org/10.1111/j.1524-4725.2007.34039.xCrossRefPubMed

32.

Monheit G, Beer K, Hardas B et al (2018) Safety and effectiveness of the hyaluronic acid dermal filler VYC-17.5L for nasolabial folds: results of a randomized. Controlled Study Dermatol Surg 44:670–678. https://doi.org/10.1097/DSS.0000000000001529CrossRefPubMed

33.

Monheit GD, Baumann LS, Gold MH et al (2010) Novel hyaluronic acid dermal filler: dermal gel extra physical properties and clinical outcomes. Dermatol Surg 36:1833–1841. https://doi.org/10.1111/j.1524-4725.2010.01780.xCrossRefPubMed

34.

Monheit GD, Campbell RM, Neugent H et al (2010) Reduced pain with use of proprietary hyaluronic acid with lidocaine for correction of nasolabial folds: a patient-blinded, prospective, randomized controlled trial. Dermatol Surg 36:94–101. https://doi.org/10.1111/j.1524-4725.2009.01389.xCrossRefPubMed

35.

Moon S-H, Lee Y-J, Rhie J-W et al (2015) Comparative study of the effectiveness and safety of porcine and bovine atelocollagen in Asian nasolabial fold correction. J Plast Surg Hand Surg 49:147–152. https://doi.org/10.3109/2000656X.2014.964725CrossRefPubMed

36.

Narins RS, Brandt FS, Lorenc ZP et al (2007) A randomized, multicenter study of the safety and efficacy of dermicol-P35 and non-animal-stabilized hyaluronic acid gel for the correction of nasolabial folds. Dermatologic Surg 33:S213–S221. https://doi.org/10.1111/j.1524-4725.2007.33364.xCrossRef

37.

Brandt F, Bank D, Cross SL, Weiss R (2010) A lidocaine-containing formulation of large-gel particle hyaluronic acid alleviates pain. Dermatol Surg 36:1876–1885. https://doi.org/10.1111/j.1524-4725.2010.01777.xCrossRefPubMed

38.

Narins RS, Coleman W, Donofrio L et al (2010) Nonanimal sourced hyaluronic acid-based dermal filler using a cohesive polydensified matrix technology is superior to bovine collagen in the correction of moderate to severe nasolabial folds: results from a 6-month, randomized, blinded, controlled, multic. Dermatol Surg 36:730–740. https://doi.org/10.1111/j.1524-4725.2010.01553.xCrossRef

39.

Nast A, Reytan N, Hartmann V et al (2011) Efficacy and durability of two hyaluronic acid-based fillers in the correction of nasolabial folds: Results of a prospective, randomized, double-blind, actively controlled clinical pilot study. Dermatol Surg 37:768–775. https://doi.org/10.1111/j.1524-4725.2011.01993.xCrossRefPubMed

40.

Onesti M, Toscani M, Curinga G et al (2009) Assessment of a new hyaluronic acid filler. double-blind, randomized, comparative study between puragen and captique in the treatment of nasolabial folds. Vivo (Brooklyn) 23:479–486

41.

Pak C, Park J, Hong J et al (2015) A phase III, randomized, multi-center, double-masked, matched-pairs, active-controlled trial to compare the efficacy and safety between neuramis deep and restylane in the correction of nasolabial folds. Arch Plast Surg 42:721–728. https://doi.org/10.5999/aps.2015.42.6.721CrossRefPubMedPubMedCentral

42.

Park KY, Park MK, Li K et al (2011) Combined treatment with a nonablative infrared device and hyaluronic acid filler does not have enhanced efficacy in treating nasolabial fold wrinkles. Dermatol Surg 37:1770–1775. https://doi.org/10.1111/j.1524-4725.2011.02164.xCrossRefPubMed

43.

Park KY, Ko EJ, Kim BJ et al (2015) A multicenter, randomized, double-blind clinical study to evaluate the efficacy and safety of PP-501-B in correction of nasolabial folds. Dermatol Surg 41:113–120. https://doi.org/10.1097/DSS.0000000000000203CrossRefPubMed

44.

Prager W, Steinkraus V (2010) A prospective, rater-blind, randomized comparison of the effectiveness and tolerability of Belotero® Basic versus Restylane® for correction of nasolabial folds. Eur J Dermatol 20:748–752. https://doi.org/10.1684/ejd.2010.1085CrossRefPubMed

45.

Prager W, Wissmueller E, Havermann I et al (2012) A prospective, split-face, randomized, comparative study of safety and 12-month longevity of three formulations of hyaluronic acid dermal filler for treatment of nasolabial folds. Dermatol Surg 38:1143–1150. https://doi.org/10.1111/j.1524-4725.2012.02468.xCrossRefPubMed

46.

Rhee DY, Won CH, Chang SE et al (2014) Efficacy and safety of a new monophasic hyaluronic acid filler in the correction of nasolabial folds: a randomized, evaluator-blinded, split-face study. J Dermatol Treat 25:448–452. https://doi.org/10.3109/09546634.2013.814756CrossRef

47.

Rzany B, Bayerl C, Bodokh I et al (2011) Efficacy and safety of a new hyaluronic acid dermal filler in the treatment of moderate nasolabial folds: 6-Month interim results of a randomized, evaluator-blinded, intra-individual comparison study. J Cosmet Laser Ther 13:107–112. https://doi.org/10.3109/14764172.2011.571699CrossRefPubMed

48.

Buntrock H, Reuther T, Prager W, Kerscher M (2013) Efficacy, safety, and patient satisfaction of a monophasic cohesive polydensified matrix versus a biphasic nonanimal stabilized hyaluronic acid filler after single injection in nasolabial folds. Dermatol Surg 39:1097–1105. https://doi.org/10.1111/dsu.12177CrossRefPubMed

49.

Rzany B, Bayerl C, Bodokh I et al (2017) An 18-month follow-up, randomized comparison of effectiveness and safety of two hyaluronic acid fillers for treatment of moderate nasolabial folds. Dermatol Surg 43:58–65. https://doi.org/10.1097/DSS.0000000000000923CrossRefPubMed

50.

Schachter D, Bertucci V, Solish N (2016) Calcium hydroxylapatite with integral lidocaine provides improved pain control for the correction of nasolabial folds. J Drugs Dermatol 15:1005–1010PubMed

51.

Sharma P, Sharma S (2011) Comparative study of a new dermal filler Uma Jeunesse®and Juvéderm®. J Cosmet Dermatol 10:118–125. https://doi.org/10.1111/j.1473-2165.2011.00556.xCrossRefPubMed

52.

Sharma PP, Sharma DK, Carr A (2018) Comparative study of UMA Jeunesse Classic®and UMA Jeunesse Ultra®. Aesthetic Plast Surg 42:1111–1118. https://doi.org/10.1007/s00266-018-1144-8CrossRefPubMed

53.

Smith S, Busso M, McClaren M, Bass LS (2007) A randomized, bilateral, prospective comparison of calcium hydroxylapatite microspheres versus human-based collagen for the correction of nasolabial folds. Dermatol Surg 33:S112–S121. https://doi.org/10.1111/j.1524-4725.2007.33350.xCrossRefPubMed

54.

Suh JH, Oh CT, Im SI et al (2017) A multicenter, randomized, double-blind clinical study to evaluate the efficacy and safety of a new monophasic hyaluronic acid filler with lidocaine 0.3% in the correction of nasolabial fold. J Cosmet Dermatol 16:327–332. https://doi.org/10.1111/jocd.12310CrossRefPubMed

55.

Taylor SC, Burgess CM, Callender VD (2010) Efficacy of variable-particle hyaluronic acid dermal fillers in patients with skin of color: a randomized, evaluator-blinded comparative trial. Dermatol Surg 36:741–749. https://doi.org/10.1111/j.1524-4725.2010.01552.xCrossRef

56.

Weiss R, Bank D, Brandt F (2010) Randomized, double-blind, split-face study of small-gel-particle hyaluronic acid with and without lidocaine during correction of nasolabial folds. Dermatol Surg 36:750–759. https://doi.org/10.1111/j.1524-4725.2010.01547.xCrossRef

57.

Wu Y, Sun N, Xu Y et al (2016) Clinical comparison between two hyaluronic acid-derived fillers in the treatment of nasolabial folds in Chinese subjects: biohyalux versus restylane. Arch Dermatol Res 308:145–151. https://doi.org/10.1007/s00403-016-1630-2CrossRefPubMed

58.

Wu Y, Xu J, Jia Y, Murphy DK (2016) Safety and effectiveness of hyaluronic acid injectable gel in correcting moderate nasolabial folds in Chinese subjects. J Drugs Dermatol 15:70–76PubMed

59.

Carruthers A, Carey W, De Lorenzi C et al (2005) Randomized, double-blind comparison of the efficacy of two hyaluronic acid derivatives, restylane perlane and hylaform, in the treatment of nasolabial folds. Dermatol Surg 31:1591–1598. https://doi.org/10.2310/6350.2005.31246CrossRefPubMed

60.

Zhou S-B, Xie Y, Chiang C-A et al (2016) A randomized clinical trial of comparing monophasic monodensified and biphasic nonanimal stabilized hyaluronic acid dermal fillers in treatment of asian nasolabial folds. Dermatol Surg 42:1061–1068. https://doi.org/10.1097/DSS.0000000000000843CrossRefPubMed

61.

Choi WJ, Han SW, Kim JE et al (2015) The efficacy and safety of lidocaine-containing hyaluronic acid dermal filler for treatment of nasolabial folds: a multicenter, randomized clinical study. Aesthetic Plast Surg 39:953–962. https://doi.org/10.1007/s00266-015-0571-zCrossRefPubMed

62.

Dover JS, Rubin MG, Bhatia AC (2009) Review of the efficacy, durability, and safety data of two nonanimal stabilized hyaluronic acid fillers from a prospective, randomized, comparative, multicenter study. Dermatologic Surg 35:322–330. https://doi.org/10.1111/j.1524-4725.2008.01060.xCrossRef

63.

Fagien S, Monheit G, Jones D et al (2018) Hyaluronic acid gel with (HARRL) and without lidocaine (HAJU) for the treatment of moderate-to-severe nasolabial folds: a randomized, evaluator-blinded, phase III study. Dermatol Surg 44:549–556. https://doi.org/10.1097/DSS.0000000000001368CrossRefPubMed

64.

Fino P, Toscani M, Grippaudo FR et al (2019) Randomized double-blind controlled study on the safety and efficacy of a novel injectable cross-linked hyaluronic gel for the correction of moderate-to-severe nasolabial wrinkles. Aesthetic Plast Surg. https://doi.org/10.1007/s00266-018-1284-xCrossRefPubMed

65.

Matthews-Brzozowska T, Swatowska A, Tuczyńska M (2019) Nasolabial folds modelling—Sliterature review. J Face Aesthet 2:46–54. https://doi.org/10.20883/jofa.10CrossRef

66.

https://www.plasticsurgery.org/documents/News/Statistics/2018/plastic-surgery-statistics-full-report-2018.pdf

67.

Signorini M, Liew S, Sundaram H et al (2016) Global aesthetics consensus: avoidance and management of complications from hyaluronic acid fillers-evidence- and opinion-based review and consensus recommendations. Plast Reconstr Surg 137:961e–971e. https://doi.org/10.1097/PRS.0000000000002184CrossRefPubMed

68.

Peng J-H, Peng PH-L (2020) HA filler injection and skin quality-literature minireview and injection techniques. Indian J Plast Surg Off Publ Assoc Plast Surg India 53:198–206. https://doi.org/10.1055/s-0040-1715545CrossRef

69.

Micheels P, Sarazin D, Besse S et al (2013) A blanching technique for intradermal injection of the hyaluronic acid Belotero. Plast Reconstr Surg 132:59S-68S. https://doi.org/10.1097/PRS.0b013e31829a02fbCrossRefPubMed

70.

Huang X, Liang Y, Li Q (2013) Safety and efficacy of hyaluronic acid for the correction of nasolabial folds: a meta-analysis. Eur J Dermatol 23:592–599. https://doi.org/10.1684/ejd.2013.2151CrossRefPubMed

71.

Wang C, Luan S, Panayi AC et al (2018) Effectiveness and safety of hyaluronic acid gel with lidocaine for the treatment of nasolabial folds: a systematic review and meta-analysis. Aesthetic Plast Surg 42:1104–1110. https://doi.org/10.1007/s00266-018-1149-3CrossRefPubMed

72.

Abduljabbar MH, Basendwh MA (2016) Complications of hyaluronic acid fillers and their managements. J Dermatol Dermato Surg 20:100–106. https://doi.org/10.1016/j.jdds.2016.01.001CrossRef

73.

Sito G, Manzoni V, Sommariva R (2019) Vascular complications after facial filler injection: a literature review and meta-analysis. J Clin Aesthet Dermatol 12:E65–E72PubMedPubMedCentral

74.

Nahai F (2020) The last word on fillers. Aesthetic Surg J. https://doi.org/10.1093/asj/sjaa255CrossRef

75.

McGuire LK, Hale EK, Godwin LS (2013) Post-filler vascular occlusion: a cautionary tale and emphasis for early intervention. J Drugs Dermatol 12:1181–1183PubMed

76.

Kim J-L, Shin JY, Roh S-G, Lee N-H (2017) Demarcative necrosis along previous laceration line after filler injection. J Craniofac Surg 28:e481–e482. https://doi.org/10.1097/SCS.0000000000003791CrossRefPubMed

77.

Rauso R, Sesenna E, Fragola R et al (2020) Skin necrosis and vision loss or impairment after facial filler injection. J Craniofac Surg 31:2289–2293. https://doi.org/10.1097/SCS.0000000000007047CrossRefPubMed

78.

Robati RM, Moeineddin F, Almasi-Nasrabadi M (2018) The risk of skin necrosis following hyaluronic acid filler injection in patients with a history of cosmetic rhinoplasty. Aesthetic Surg J 38:883–888. https://doi.org/10.1093/asj/sjy005CrossRef

79.

Goodman GJ, Roberts S, Callan P (2016) Experience and management of intravascular injection with facial fillers: results of a multinational survey of experienced injectors. Aesthet Plast Surg 40:549–555. https://doi.org/10.1007/s00266-016-0658-1CrossRef

80.

Lee W, Kim J-S, Moon H-J, Yang E-J (2020) A safe doppler ultrasound-guided method for nasolabial fold correction with hyaluronic acid filler. Aesthet Surg J. https://doi.org/10.1093/asj/sjaa153CrossRefPubMedPubMedCentral

81.

Chauhan A, Singh S (2019) Management of delayed skin necrosis following hyaluronic acid filler injection using pulsed hyaluronidase. J Cutan Aesthet Surg 12:183–186CrossRefPubMedPubMedCentral

82.

Sun Z-S, Zhu G-Z, Wang H-B et al (2015) Clinical outcomes of impending nasal skin necrosis related to nose and nasolabial fold augmentation with hyaluronic acid fillers. Plast Reconstr Surg 136:e434–e441. https://doi.org/10.1097/PRS.0000000000001579CrossRef

83.

Rubin MG (2004) Treatment of nasolabial folds with fillers. Aesthetic Surg J 24:489–493. https://doi.org/10.1016/j.asj.2004.06.004CrossRef

Title: Tissue Fillers for the Nasolabial Fold Area: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Authors: Tomasz Stefura
Artur Kacprzyk
Jakub Droś
Marta Krzysztofik
Oksana Skomarovska
Marta Fijałkowska
Mateusz Koziej
Publication date: 01-10-2021
Publisher: Springer US
Keyword: Injectable Filler
Published in: Aesthetic Plastic Surgery / Issue 5/2021
Print ISSN: 0364-216X
Electronic ISSN: 1432-5241
DOI: https://doi.org/10.1007/s00266-021-02439-5

At a glance: The STEP trials

Springer Medicine

Tissue Fillers for the Nasolabial Fold Area: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Abstract

Level of Evidence II

At a glance: The STEP trials

Springer Medicine

Abstract

Level of Evidence II

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