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International Orthopaedics

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01-07-2019 | Femoral Fracture | Original Paper

Haematology panel biomarkers for humeral, femoral, and tibial diaphyseal fractures

Authors: Luchian Alexandru, Horia Haragus, Bogdan Deleanu, Bogdan Timar, Dan V. Poenaru, Daliborca Cristina Vlad

Published in: International Orthopaedics | Issue 7/2019

Abstract

Purpose

The neutrophil to lymphocyte ratio (NLR) is a simple predictor used in oncology and cardiology. We aimed to analyze the NLR profile of patients with diaphyseal fractures of the humerus, femur, and tibia.

Methods

We performed a cross-sectional, consecutive-case population-based study including 148 patients (41.9% men respectively 58.1% women) with humeral (23.0%), femoral (30.4%), and tibial (46.6%) diaphyseal fractures, admitted for surgical treatment in our level 1 trauma centre over two years.

Results

The differences in NLR between the studied subgroups were not significant (p = 0.067), the highest value being observed in patients with femoral fracture (5.6) in contrast to patients with humeral fracture (4). In the global cohort, there was a significantly positive correlation between NLR and PLR (platelet to lymphocyte ratio; Spearman’s r = 0.595; p < 0.001). The stratified subgroup analysis found significant association between NLR and duration of admission only for patients with femoral fracture (Spearman’s r = − 0.308; p < 0.001). When compared with controls, all three fracture types had significantly higher neutrophil numbers and NLR and lower thrombocyte numbers.

Conclusions

NLR are elevated in femur diaphyseal fractures compared with tibia and humerus, up to cut-off values with negative prediction of outcome in malignancy and cardiovascular patients. Increased NLR are predictive of longer hospital admissions for femur fractures.

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Title: Haematology panel biomarkers for humeral, femoral, and tibial diaphyseal fractures
Authors: Luchian Alexandru
Horia Haragus
Bogdan Deleanu
Bogdan Timar
Dan V. Poenaru
Daliborca Cristina Vlad
Publication date: 01-07-2019
Publisher: Springer Berlin Heidelberg
Keywords: Femoral Fracture
Tibia Fracture
Published in: International Orthopaedics / Issue 7/2019
Print ISSN: 0341-2695
Electronic ISSN: 1432-5195
DOI: https://doi.org/10.1007/s00264-019-04305-1

At a glance: The STEP trials

Springer Medicine

Haematology panel biomarkers for humeral, femoral, and tibial diaphyseal fractures

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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