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International Orthopaedics
Published in: International Orthopaedics 2/2019

Open Access 01-02-2019 | Original Paper

Total hip arthroplasty in osteonecrosis secondary to sickle cell disease

Authors: Mohamed Zubair Farook, Moji Awogbade, Karthik Somasundaram, Ines L. H. Reichert, Patrick L. S. Li

Published in: International Orthopaedics | Issue 2/2019

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Abstract

Background

Sickle cell disease (SCD) is a multisystem disease, and the predominant articular manifestation is osteonecrosis (ON). Total hip arthroplasty (THA) is technically challenging, and the complication rates are high. In this retrospective study, we have analysed the outcome of THA in a cohort of patients with SCD at our institution.

Materials and methods

We identified 34 THAs between 1999 and 2016 in 30 patients (mean age 37 years) from our SCD database. Co-morbidities, both sickle and non-sickle-related, were documented. Complications and indications for revision surgery were analysed.

Results

An uncemented prosthesis was predominantly used. The mean follow-up was 10.5 years (range 1–18). Six patients had revision surgery (17.6%), 2 (5.8%) for Prosthetic Joint Infection (PJI), and 4 (11.7%) for osteolysis of the acetabular component.

Conclusion

Our revision rates were comparable to the published literature. Our combined sickle cell clinic and the coordinated multidisciplinary management have been successful in reducing morbidity.
Literature
1.
Acurio MT, Friedman RJ (1992) Hip arthroplasty in patients with sickle-cell haemoglobinopathy. J Bone Joint Surg Br 74(3):367–371CrossRefPubMed
2.
3.
AlOmran AS (2010) Choice of implant in total hip arthroplasty for sickle cell disease patients. Eur Orthop Traumatol 1:25–29CrossRef
4.
Azam MQ, Ali M (2016) Quality of life in sickle cell patients after cementless total hip arthroplasty. J Arthroplast 31(11):2536–2541CrossRef
5.
Brooker AF, Bowerman JW, Robinson RA, Riley Jr LH (1973) Ectopic ossification following total hip replacement. Incidence and a method of classification. J Bone Joint Surg Am 55(8):1629–1632CrossRef
6.
Clarke HJ, Jinnah RH, Brooker AF, Michaelson JD (1989) Total replacement of the hip for avascular necrosis in sickle cell disease. J Bone Joint Surg Br 71(3):465–470CrossRefPubMed
7.
DeLee JG, Charnley J (1976) Radiological demarcation of cemented sockets in total hip replacement. Clin Orthop Relat Res 121:20–32
8.
Engh CA, Massin P, Suthers KE (1990) Roentgenographic assessment of the biologic fixation of porous surfaced femoral components. Clin Orthop Relat Res 257:107–128
9.
Estcourt LJ, Fortin PM, Trivella M, Hopewell S (2016) Preoperative blood transfusions for sickle cell disease. Cochrane Database Syst Rev 4:CD003149PubMedPubMedCentral
10.
Gruen TA, McNeice GM, Amstutz HC (1979) Modes of failure’ of cemented stem-type femoral components: a radiographic analysis of loosening. Clin Orthop Relat Res 141:17–27
11.
Gulati Y, Sharma M, Bharti B, Bahl V, Bohra I, Goswani A (2015) Short term results of cementless total hip arthroplasty in sicklers. Indian J Orthop 49(4):447–451CrossRefPubMedPubMedCentral
12.
Hanker GJ, Amstutz HC (1988) Osteonecrosis of the hip in sickle cell disease. J Bone Joint Surg Am 70(4):499–506CrossRefPubMed
13.
Hernigou P, Bachir D, Galacteros F (2003) The natural history of symptomatic osteonecrosis in adults with sickle cell disease. J Bone Joint Surg Am 85-A(3):500–504CrossRef
14.
Hernigou P, Habibi A, Bachir D, Galacteros F (2006) The natural history of asymptomatic osteonecrosis in adults with sickle cell disease. J Bone Joint Surg Am 88(12):2565–2572CrossRefPubMed
15.
16.
Hug KT, Gupta AK, Wellman SS, Bolognesi MP, Attarian DE (2013) Creation of a femoral cortical window to facilitate total hip arthroplasty in patients with sickle cell hemoglobinopathies. J Arthroplast 28(2):323–325CrossRef
17.
Ilyas I, Alrumaih HA, Rabbani S (2018) Noncemented total hip arthroplasty in sickle-cell disease: long term results. J Arthroplast 33(2):477–481CrossRef
18.
Issa K, Naziri Q, Maheshwari AV, Rasquinha VJ, Delanois RE, Mont MA (2013) Excellent results and minimal complications of total hip arthroplasty in sickle cell hemoglobinopathy at mid-term follow-up using cementless prosthetic components. Arthroplasty 28(9):1693–1698CrossRef
19.
Jack CM, Howard J, Aziz ES, Kesse-Adu R, Bankes MJ (2016) Cementless total hip replacements in sickle cell disease. Hip Int 26(2):186–192CrossRefPubMed
20.
Langlais F, Kerboull M, Sedel L, Ling RSM (2003) The French paradox. J Bone Joint Surg Br 85:17–20CrossRefPubMed
21.
Perfetti DC, Boylan MR, Naziri Q, Khanuja HS, Urban WP (2015) Does sickle cell disease increase risk of adverse outcomes following total hip and knee arthroplasty? A Nationwide Database Study. J Arthroplasty 30(4):547–551CrossRefPubMed
22.
Platt OS, Brambilla DJ, Rosse WF, Milner PF, Castro O, Steinberg MH, Klug PP (1994) Mortality in sickle cell disease. Life expectancy and risk factors for early death. N Engl J Med 330:1639–1644CrossRefPubMed
23.
Steinberg ME, Hayen GD, Steinberg D (1995) A quantitative system for staging avascular necrosis. J Bone Joint Surg Br 77:34–41CrossRefPubMed
24.
Stephenson PK, Freeman MAR (1991) Exposure of the hip using a modified anterolateral approach. J Anthrop 6(2):137–145
25.
Vichinsky EP, Neumayr LD, Haberkern C, Earles AN, Eckman J, Koshy M, Black DM (1999) The perioperative complication rate of orthopaedic surgery in sickle cell disease: report of the National Sickle Cell Surgery Study Group. Am J Hematol 62(3):129–138CrossRefPubMed
Metadata
Title
Total hip arthroplasty in osteonecrosis secondary to sickle cell disease
Authors
Mohamed Zubair Farook
Moji Awogbade
Karthik Somasundaram
Ines L. H. Reichert
Patrick L. S. Li
Publication date
01-02-2019
Publisher
Springer Berlin Heidelberg
Published in
International Orthopaedics / Issue 2/2019
Print ISSN: 0341-2695
Electronic ISSN: 1432-5195
DOI
https://doi.org/10.1007/s00264-018-4001-0

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