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International Orthopaedics
Published in: International Orthopaedics 7/2018

01-07-2018 | Original Paper

Combined pharmacotherapy for osteonecrosis of the femoral head after severe acute respiratory syndrome and interstitial pneumonia: two and a half to fourteen year follow-up

Authors: Weiguo Wang, Nianfei Zhang, Wanshou Guo, Fuqiang Gao

Published in: International Orthopaedics | Issue 7/2018

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Abstract

Purpose

The purpose of this study was to retrospectively analyze the clinical, functional, and radiological outcomes of combined pharmacotherapy to ONFH after high-dose corticosteroid therapy.

Method

From August 2003 to June 2015, five patients (ten hips) of ONFH in ARCO stage I, after SARS and Interstitial pneumonia, were treated by combined pharmacotherapy. Lipo-prostaglandin E1 10 μg iv Bid × 28 days, enoxaparin 6000 iu H QD × 12 weeks, alendronate sodium tablet 10 mg QD × 1 year. The patients were fully weight-bearing following completion of the follow-up.

Result

For these five patients (ten hips), Harris score was 100 from the diagnosis to final follow-up time. Radiologic findings show no signs of collapse, necrotic focus was repaired, and ARCO stages were changed from IC into IIB.

Conclusion

This combined pharmacotherapy has promising treatment results for delaying or preventing collapse of ONFH in ARCO stage I.
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Metadata
Title
Combined pharmacotherapy for osteonecrosis of the femoral head after severe acute respiratory syndrome and interstitial pneumonia: two and a half to fourteen year follow-up
Authors
Weiguo Wang
Nianfei Zhang
Wanshou Guo
Fuqiang Gao
Publication date
01-07-2018
Publisher
Springer Berlin Heidelberg
Published in
International Orthopaedics / Issue 7/2018
Print ISSN: 0341-2695
Electronic ISSN: 1432-5195
DOI
https://doi.org/10.1007/s00264-018-3907-x

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