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International Orthopaedics
Published in: International Orthopaedics 12/2018

01-12-2018 | Original Paper

Stem cell therapy in early post-traumatic talus osteonecrosis

Authors: Philippe Hernigou, Arnaud Dubory, Charles Henri Flouzat Lachaniette, Issam Khaled, Nathalie Chevallier, Helene Rouard

Published in: International Orthopaedics | Issue 12/2018

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Abstract

Purpose

Avascular necrosis of the talus is one of the most notable complications associated with talar neck fractures with frequent evolution of the osteonecrosis into a difficult arthrodesis. We tested whether the injection of bone marrow mesenchymal stem cells (MSCs) could improve the repair process of the osteonecrosis.

Material and methods

Forty-five early (without collapse) post-traumatic talus osteonecroses (group 1; study group) were treated between 1995 and 2012 with percutaneous injection of progenitor cells (autologous bone marrow concentrate from the iliac crest). The number of MSCs transplanted in each ankle of group 1 was 124 × 103 cells (range 101 × 103 to 164 × 103 cells). The evolution of these osteonecroses treated with autologous bone marrow implantation was compared with the evolution of a control group of 34 talar osteonecroses without collapse and treated with only core decompression (group 2; control group) between 1985 and 1995. The outcome was determined by progression in radiographic stages to collapse, by the need of arthrodesis, and by the time to successfully achieve fusion for patients who needed arthrodesis.

Results

For the 45 ankles with autologous concentrate bone marrow grafting, collapse frequency was lower (27%, 12 among 45 versus 71%, 24 among 34; odds ratio 0.1515, 95% CI 0.0563–0.4079; P = 0.0002) and follow-up showed longer duration of survival before collapse or arthrodesis, compared to 34 ankles of the control patients with core decompression alone. Furthermore, the time to successfully achieve fusion after arthrodesis was significantly shorter in patients treated with bone marrow progenitors as compared with the other ankles, which had core decompression alone.

Conclusion

In our study the early conservative surgical treatment with autologous bone marrow grafting improved the natural course of the disease as compared with core decompression alone.
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Metadata
Title
Stem cell therapy in early post-traumatic talus osteonecrosis
Authors
Philippe Hernigou
Arnaud Dubory
Charles Henri Flouzat Lachaniette
Issam Khaled
Nathalie Chevallier
Helene Rouard
Publication date
01-12-2018
Publisher
Springer Berlin Heidelberg
Published in
International Orthopaedics / Issue 12/2018
Print ISSN: 0341-2695
Electronic ISSN: 1432-5195
DOI
https://doi.org/10.1007/s00264-017-3716-7

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